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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neuromedin B receptor

neuromedin B receptor, NMB-R
Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bombesin, Gastrin, gastrin-releasing peptide receptor, neuromedin B, BRS-3
Papers on neuromedin B receptor
Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells.
New
Jensen et al., Bethesda, United States. In Peptides, Jan 2016
None of the four chiral diazepine analogs activated r,m,h-GRPR/NMBR.
Viability of D283 medulloblastoma cells treated with a histone deacetylase inhibitor combined with bombesin receptor antagonists.
New
Roesler et al., Porto Alegre, Brazil. In Childs Nerv Syst, Dec 2015
METHODS: D283 MB cells were treated with different doses of the HDACi sodium butyrate (NaB), the neuromedin B receptor (NMBR) antagonist BIM-23127, the gastrin releasing peptide receptor (GRPR) antagonist RC-3095, or combinations of NaB with each receptor antagonist.
Cloning of neuromedin B and its receptor in the rabbit and generating a polyclonal antibody to the neuromedin B protein.
New
Lei et al., Nanjing, China. In Gene, Jul 2015
Neuromedin B (NMB) executes its effect by binding to the cell surface receptor, neuromedin B receptor (NMBR).
Bombesin-like peptides and their receptors: recent findings in pharmacology and physiology.
Review
New
Qin et al., Changsha, China. In Curr Opin Endocrinol Diabetes Obes, Feb 2015
Both gastrin-releasing peptide receptor and neuromedin B receptor activation were shown to induce membrane depolarization and excite neurons in brain.
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.
New
Jensen et al., Bethesda, United States. In Peptides, Feb 2015
PD168368 is a nonpeptide antagonist for the neuromedin B (NMB) receptor (R) whereas PD176252 is a nonpeptide antagonist for the gastrin releasing peptide (GRP) R and NMBR but not BRS-3.
Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors.
Yanagisawa et al., Tokyo, Japan. In Plos One, 2014
We purified peptide E as a low-affinity ligand for hBRS3, which was also found to be an agonist for the other two mammalian bombesin receptors such as gastrin-releasing peptide receptor (GRPR) and neuromedin B receptor (NMBR).
Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene.
Pazos-Moura et al., Rio de Janeiro, Brazil. In Regul Pept, 2014
Here we studied the thyroid axis of adult female mice lacking neuromedin B receptor (NBR-KO), compared to wild type (WT) littermates.
Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission.
Chen et al., Xi'an, China. In J Neurosci, 2014
Neuromedin B receptor (NMBR), the second member of the mammalian bombesin receptor family, is expressed in a largely nonoverlapping pattern with GRPR in the superficial spinal cord, and its role in itch transmission remains unclear.
The role of the orphan G protein-coupled receptor 37 (GPR37) in multiple myeloma cells.
Cheng et al., Nantong, China. In Leuk Res, 2014
The orphan G protein-coupled receptor 37 (GPR37) is homologous to endothelin (ETB-R) and bombesin (GRP-R, NMB-R) receptors.
Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1α.
Bae et al., Yangsan, South Korea. In Plos One, 2012
The neuromedin B receptor (NMB-R), a member of the mammalian bombesin receptor family, is frequently overexpressed in various tumors.
The role of bombesin and bombesin-related peptides in the short-term control of food intake.
Review
Sayegh, United States. In Prog Mol Biol Transl Sci, 2012
These peptides evoke a number of responses, including hyperthermia, bradycardia, inhibition of gastric emptying and inhibition of food intake, by activating one of three G protein-coupled receptors: an NMB-R or BB(1), a GRP-R or BB(2) and an orphan Bn receptor subtype-3 (BRS-3) or BB(3).
(99m)Tc-Hydrazinonicotinyl(tricine)(TPPTS)-Glu-c(RGDyK)-bombesin[7-14]NH2
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
The BBN-R superfamily includes at least four different subtypes, namely the GRPR subtype (BB2), the neuromedin B receptor subtype (BB1), the BB3 subtype, and the BB4 subtype.
(64)Cu-1,4,7-Triazacyclononane-1,4-diacetic acid-c(RGDyK)-Glu-6-aminohexanoic acid-bombesin[7-14]NH2
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
The BBN-R superfamily includes at least four different subtypes, namely the GRPR subtype (BB2), the neuromedin B receptor subtype (BB1), the BB3 subtype, and the BB4 subtype.
Neuromedin B and its receptor influence the activity of myometrial primary cells in vitro through regulation of Il6 expression via the Rela/p65 pathway in mice.
GeneRIF
Liang et al., Changsha, China. In Biol Reprod, 2012
The data demonstrated that the neuromedin B-neuromedian B receptor interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 expression via the Rela/p65 pathway.
Bombesin receptor regulation of emotional memory.
Review
Merali et al., Porto Alegre, Brazil. In Rev Neurosci, 2011
Mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide (GRP) act by activating NMB receptors (NMBR, BBl) and GRP receptors (GRPR,BB2), respectively.
Neuromedin B and its receptor induce labor onset and are associated with the RELA (NFKB P65)/IL6 pathway in pregnant mice.
GeneRIF
Liang et al., Changsha, China. In Biol Reprod, 2011
These data demonstrate that neuromedin B and its receptor can induce the onset of labor via a RELA/IL6-mediated pathway.
Female mice target deleted for the neuromedin B receptor have partial resistance to diet-induced obesity.
GeneRIF
Pazos-Moura et al., Rio de Janeiro, Brazil. In J Physiol, 2010
disruption of the neuromedin B receptor pathway did not change body weight homeostasis in female mice fed a normolipid diet
Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor.
GeneRIF
Jensen et al., Bethesda, United States. In J Pharmacol Exp Ther, 2009
Selectivity of NMBR for neuromedin B over the gastrin-releasing peptide receptor depends primarily on differences in amino acids in the third extracellular domains of the receptors and in the adjacent upper fifth transmembrane region of the two receptors.
[Expression of NMBR in myometrium in pregnant mice at different gestational ages and its relation with parturition].
GeneRIF
Liang et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2009
The mRNA and protein expressions of NMBR reach a peak at the onset of labor.
Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.
Impact
Wada et al., Kodaira, Japan. In Nature, 1997
Bombesin-like peptide receptors cloned so far include, gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R), and bombesin receptor subtype-3 (BRS-3).
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