SHANK1 and autism spectrum disorders.
Shanghai, China. In Sci China Life Sci, Oct 2015
The Neurexin-Neuroligin-Shank (NRXN-NLGN-SHANK) pathway plays a key role in the formation, maturation and maintenance of synapses, consistent with the hypothesis of neurodevelopmental abnormality in ASD.
Translational control of nociception via 4E-binding protein 1.
Montréal, Canada. In Elife, 2014
Mice lacking 4E-BP1 exhibit enhanced spinal cord expression of neuroligin 1, a cell-adhesion postsynaptic protein regulating excitatory synapse function, and show increased excitatory synaptic input into spinal neurons, and a lowered threshold for induction of synaptic potentiation.
Thrombospondins and synaptogenesis.
Zhanjiang, China. In Neural Regen Res, 2012
Thrombospondin regulates synaptogenesis through receptor α2δ-1 and neuroligin 1, and promotes the proliferation and differentiation of neural progenitor cells.