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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neuroligin 1

neuroligin-1, Neuroligin, Nlgn1
transmembrane ligand for neurexins; involved in development and maturation of synaptic connections [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, NL3, PSD-95, ANGPTL4, NLGN4
Papers on neuroligin-1
Expression and Modulation of Neuroligin and Neurexin in the Olfactory Organ of the Cotton Leaf Worm Spodoptera littoralis.
New
Maïbèche et al., Paris, France. In Insect Sci, Feb 2016
One neuroligin, Slnlg4-yll and its putative binding partner neurexin SlnrxI were the most expressed in the antennae and were surprisingly associated with olfactory sensilla.
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Review
New
Lichtenthaler et al., Kiel, Germany. In Prog Neurobiol, Dec 2015
Mechanistically, ADAM10 controls these functions by utilizing unique postsynaptic substrates in the central nervous system, in particular synaptic cell adhesion molecules, such as neuroligin-1, N-cadherin, NCAM, Ephrin A2 and A5.
Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
New
Impact
Monje et al., Stanford, United States. In Cell, Jun 2015
The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust HGG cell proliferation.
A network of autism linked genes stabilizes two pools of synaptic GABAA receptors.
Kaplan et al., Boston, United States. In Elife, 2014
Diffusing GABAA receptors are stabilized by the synaptic adhesion molecules Neurexin and Neuroligin.
Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.
Sigrist et al., Berlin, Germany. In Nat Commun, 2014
Neuroligin-1/neurexin-1/Syd-1 levels are increased at spinophilin mutant NMJs, and removal of single copies of the neurexin-1, Syd-1 or neuroligin-1 genes suppresses the spinophilin-active zone phenotype.
Translational control of nociception via 4E-binding protein 1.
Sonenberg et al., Montréal, Canada. In Elife, 2014
Mice lacking 4E-BP1 exhibit enhanced spinal cord expression of neuroligin 1, a cell-adhesion postsynaptic protein regulating excitatory synapse function, and show increased excitatory synaptic input into spinal neurons, and a lowered threshold for induction of synaptic potentiation.
Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphisms with Schizophrenia in Chinese Han Population.
Yue et al., Beijing, China. In Plos One, 2014
Then, we selected one promising gene neuroligin 1 (NLGN1) to further investigate the association between eight significant SNPs and schizophrenia in an independent sample (1814 schizophrenia cases and 1487 healthy controls).
Neuroligins, synapse balance and neuropsychiatric disorders.
Review
Wędzony et al., Kraków, Poland. In Pharmacol Rep, 2014
Four neuroligin proteins have been identified (neuroligin 1, 2, 3, 4), which are differentially enriched in the postsynaptic specialisation of synapses.
[Synapse maturation and autism: learning from neuroligin model mice].
Review
Pramanik et al., In Nihon Shinkei Seishin Yakurigaku Zasshi, 2014
A mutation that substitutes cysteine for arginine at residue 451 of Neuroligin-3 (R451C) is the first monogenic mutation identified in idiopathic autism patients.
Autism-related deficits via dysregulated eIF4E-dependent translational control.
Impact
Sonenberg et al., Montréal, Canada. In Nature, 2013
Pharmacological inhibition of eIF4E activity or normalization of neuroligin 1, but not neuroligin 2, protein levels restores the normal excitation/inhibition ratio and rectifies the social behaviour deficits.
A review on the current neuroligin mouse models.
Review
Xia et al., Hangzhou, China. In Sheng Li Xue Bao, 2012
Neuroligin family proteins can specifically induce either excitatory or inhibitory synapses.
Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism.
Impact
Scheiffele et al., Basel, Switzerland. In Science, 2012
Neuroligin-3 knockout mice (a model for nonsyndromic autism) exhibited disrupted heterosynaptic competition and perturbed metabotropic glutamate receptor-dependent synaptic plasticity, a hallmark of fragile X.
Homodimerization and isoform-specific heterodimerization of neuroligins.
GeneRIF
Brose et al., Göttingen, Germany. In Biochem J, 2012
Data from studies using cross-linking reagents suggest that neuroligins in neurons cultured from embryonic hippocampus, striatum, or cerebellum form constitutive dimers, including homodimers and, most notably, neuroligin 1/3 heteromers.
Thrombospondins and synaptogenesis.
Review
Huang et al., Zhanjiang, China. In Neural Regen Res, 2012
Thrombospondin regulates synaptogenesis through receptor α2δ-1 and neuroligin 1, and promotes the proliferation and differentiation of neural progenitor cells.
Distinct roles of neuroligin-1 and SynCAM1 in synapse formation and function in primary hippocampal neuronal cultures.
GeneRIF
Meriney et al., Pittsburgh, United States. In Neuroscience, 2012
This study presented evidence that combined NL1 and SC1 overexpression triggers excitotoxic neurodegeneration through SC1 signaling at synaptic connections initiated by NL1.
Functional expression of rat neuroligin-1 extracellular fragment by a bi-cistronic baculovirus expression vector.
GeneRIF
Wu et al., Taiwan. In Protein Expr Purif, 2012
NL1 protein was obtained from the supernatant of the recombinant virus-infected High Five insect cells. It was shown that purified rat NL1 promoted and enhanced the growth rate of axons.
The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?
GeneRIF
Inestrosa et al., Santiago, Chile. In Biochemistry, 2011
Amyloid beta-peptide binds to the extracellular domain of neuroligin-1 with a K(d) in the nanomolar range.
Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds.
GeneRIF
Thoumine et al., Bordeaux, France. In J Neurosci, 2011
these data reveal a mechanism by which membrane-diffusing AMPARs can be rapidly trapped at PSD-95 scaffolds assembled at nascent neurexin/neuroligin adhesions, in competition with existing synapses.
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.
Impact
Hakonarson et al., Philadelphia, United States. In Nature, 2009
10) and CNTN4 (refs 11, 12), several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls (P = 9.5 x 10(-3)).
A monovalent streptavidin with a single femtomolar biotin binding site.
Impact
Ting et al., Cambridge, United States. In Nat Methods, 2006
Labeling of site-specifically biotinylated neuroligin-1 with monovalent streptavidin allowed stable neuroligin-1 tracking without cross-linking, whereas wild-type streptavidin aggregated neuroligin-1 and disrupted presynaptic contacts.
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