Genetics of Hypogonadotropic Hypogonadism.
In Endocr Dev, Dec 2015
Also, discovery of mutations in KISS1/KISS1R and TAC3/TACR3 in kisspeptin and neurokinin B signaling, respectively, has provided major advancements in our understanding of the biology of the gonadotropin-releasing hormone pulse generator.
[Effects of Suspending Moxibustion at "Dazhui" (GV 14) on Neurogenic Inflammation in Asthma Rats].
In Zhen Ci Yan Jiu, Oct 2015
OBJECTIVE: To observe the effect of suspending-moxibustion stimulation of "Dazhui" (GV 14) with different quantities on the levels of nerve growth factor(NGF) , substance P(SP) , calcitonin gene-related peptide (CGRP), neurokinin A (NKA) , neurokinin B (NKB) and phosphorylated extracellular signal-regulated kinases (pERK) in the bronchoalveolar lavage fluid (BALF) of asthma rats, so as to analyze its mechanisms underlying improving asthma.
Physiology of Gnrh and Gonadotropin Secretion
Madagascar. In Unknown Journal, Aug 2015
Translational clinical studies, exploring kisspeptin and neurokinin B activity in various physiological and pathological states are pivotal to potential clinical applications for these novel neuropeptides and their agonists as well as antagonists.
The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges.
Charlottesville, United States. In Endocr Rev, 2010
Here we review the current knowledge of the neurobiology of the GnRH surge, in particular the actions of estradiol on GnRH neurons and their synaptic afferents, the regulation of GnRH neurons by fast synaptic transmission mediated by the neurotransmitters gamma-aminobutyric acid and glutamate, and the host of excitatory and inhibitory neuromodulators including kisspeptin, vasoactive intestinal polypeptide, catecholamines, neurokinin B, and RFamide-related peptides, that appear essential for GnRH surge regulation, and ultimately ovulation and fertility.
Kisspeptin signaling in the brain.
Seattle, United States. In Endocr Rev, 2009
Kisspeptin neurons are sexually differentiated with respect to cell number and transcriptional activity in certain brain nuclei, and some kisspeptin neurons express other cotransmitters, including dynorphin and neurokinin B (whose physiological significance is unknown).