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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neurofascin

Neurofascin, Nfasc
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: NODAL, contactin, Bravo, CAN, OUT
Papers on Neurofascin
Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier.
New
Brophy et al., London, United Kingdom. In J Neurosci, Mar 2015
The Neurofascin (Nfasc) gene has a unique role in node formation because it encodes glial and neuronal isoforms of neurofascin (Nfasc155 and Nfasc186, respectively) with key functions in assembling the nodal macromolecular complex.
Gene expression profile of brain regions reflecting aberrations in nervous system development targeting the process of neurite extension of rat offspring exposed developmentally to glycidol.
Shibutani et al., Fuchū, Japan. In J Appl Toxicol, 2014
Downregulated genes in the dentate gyrus were related to axonogenesis (Nfasc), myelination (Mal, Mrf and Ugt8), and cell proliferation (Aurkb and Ndc80) at ≥ 300 ppm, and upregulated genes were related to neural development (Frzb and Fzd6) at 1000 ppm.
In vivo assembly of the axon initial segment in motor neurons.
Couraud et al., Paris, France. In Brain Struct Funct, 2014
Analysis on the global motor neurons population indicated that Neurofascin follows an identical spatio-temporal distribution, whereas sodium channels and β4-spectrin only appear along AnkG(+) segments at E11.5.
Differential stability of PNS and CNS nodal complexes when neuronal neurofascin is lost.
Brophy et al., Edinburgh, United Kingdom. In J Neurosci, 2014
The Neurofascin (Nfasc) gene encodes neuronal Neurofascin 186 (Nfasc186) at the node and glial Neurofascin 155 at the paranode, and these proteins play a key role in node assembly.
Novel cerebellum-enriched miR-592 may play a role in neural progenitor cell differentiation and neuronal maturation through regulating Lrrc4c and Nfasc in rat.
Yu et al., Shanghai, China. In Curr Mol Med, 2013
We also identified Lrrc4c and Nfasc as miR-592 target genes, and miR-592 could affect the changes of Lrrc4c and Nfasc expression levels, suggesting that these two target genes may be involved in miR-592 regulative function in NPCs differentiation and neuronal maturation.
Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis.
Linington et al., Glasgow, United Kingdom. In Exp Neurol, 2013
Recently, it was demonstrated that autoantibodies against Neurofascin, a cell adhesion molecule within the adult nervous system, can contribute to the development of axonal pathology in some patients.
CHL1 is involved in human breast tumorigenesis and progression.
Tong et al., Tianjin, China. In Biochem Biophys Res Commun, 2013
The L1 family of CAMs is comprised of L1, Close Homolog of L1 (CHL1, L1CAM2), NrCAM, and Neurofascin, which are structurally related trans-membrane proteins in vertebrates.
Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.
Patrakka et al., Stockholm, Sweden. In Kidney Int, 2013
Unexpectedly, the survey found expression of three neuronal proteins (Huntingtin interacting protein 1 (Hip1), neurofascin (Nfasc), and olfactomedin-like 2a (Olfml2a)), all enriched in the glomerulus.
Distinct cis regulatory elements govern the expression of TAG1 in embryonic sensory ganglia and spinal cord.
Klar et al., Jerusalem, Israel. In Plos One, 2012
The Ig/FNIII superfamily molecules TAG1/Axonin1/CNTN2 (TAG1) and Neurofascin (Nfasc) are co-expressed in numerous neuronal cell types in the CNS and PNS - for example motor, DRG and interneurons - both promote neurite outgrowth and both are required for the architecture and function of nodes of Ranvier.
Neurofascin: a switch between neuronal plasticity and stability.
GeneRIF
Volkmer et al., Reutlingen, Germany. In Int J Biochem Cell Biol, 2012
Neurofascin isoforms of 186, 180, 166 and 155 kDa are generated by alternative splicing and provide a switch between neuronal plasticity and stability. (Review)
Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development.
GeneRIF
Bhat et al., Chapel Hill, United States. In J Neurosci, 2012
Cerebellar pinceau organization requires coordinated mechanisms involving specific neurofascin functions in both Purkinje and basket neurons.
Nodal proteins are target antigens in Guillain-Barré syndrome.
GeneRIF
Yuki et al., Saint-Pierre-des-Corps, France. In J Peripher Nerv Syst, 2012
gliomedin, NF186, and contactin are novel target antigens in Guillain-Barre syndrome
Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier.
GeneRIF
Faivre-Sarrailh et al., Marseille, France. In J Biol Chem, 2012
Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier
Rapid disruption of axon-glial integrity in response to mild cerebral hypoperfusion.
Horsburgh et al., Edinburgh, United Kingdom. In J Neurosci, 2012
This was marked by a progressive reduction of paranodal Neurofascin signal and a loss of septate-like junctions.
The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment.
GeneRIF
Volkmer et al., Reutlingen, Germany. In J Biol Chem, 2011
overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways.
A critical role for Neurofascin in regulating action potential initiation through maintenance of the axon initial segment.
GeneRIF
Brophy et al., Edinburgh, United Kingdom. In Neuron, 2011
We propose that neurofascin optimizes communication between mature neurons by anchoring the key elements of the adult axon initial segment complex.
Nodes of Ranvier act as barriers to restrict invasion of flanking paranodal domains in myelinated axons.
GeneRIF
Bhat et al., Chapel Hill, United States. In Neuron, 2011
Results suggest that neurofascin-dependent assembly of the nodal complex acts as a molecular boundary, facilitating axonal domain organization and saltatory conduction along myelinated axons.
Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways.
Barthold et al., Wilmington, United States. In Biol Reprod, 2010
Several of the genes showing the largest inductions regulate neuronal development or activity, including Pnoc (34-fold), Nptx2 (9-fold), Nfasc (4-fold), Gfra3 (3-fold), Unc5d (3-fold), and Crlf1 (3-fold).
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