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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neurogenic differentiation 6

NeuroD6, A Th2, MATH-2, NEX-1
NEUROD6 is a member of the NEUROD (NEUROD1; MIM 601724) family of basic helix-loop-helix (bHLH) transcription factors (Guo et al., 2002 [PubMed 12357074]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: TH2, CAN, IL-4, HAD, IFN-gamma
Papers on NeuroD6
Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease.
New
Mayeux et al., New York City, United States. In Alzheimers Dement, Dec 2015
We additionally identified a locus at 7p14.3 (rs10255835: HLODmax = 4.9, Pjoint = 1.2 × 10(-5)), a region harboring genes associated with the nervous system (GARS, GHRHR, and NEUROD6).
Soil-Transmitted Helminth Infections Are Associated With an Increase in Human Papillomavirus Prevalence and a T-Helper Type 2 Cytokine Signature in Cervical Fluids.
New
Gilman et al., Lima, Peru. In J Infect Dis, Nov 2015
In Iquitos, A Th2 immune profile was observed in cervical fluid from helminth-infected women but not helminth-uninfected women.
Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis.
New
Boeckxstaens et al., Leuven, Belgium. In Gut, Jul 2015
A Th2 cytokine phenotype at time of infection was associated with increased risk for PI-IBS 1 year later.
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
New
Nestadt et al., Århus, Denmark. In Mol Psychiatry, Mar 2015
for a set of genes such as NEUROD6, SV2A, GRIA4, SLC1A2 and PTPRD.
RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsets.
New
Varga et al., Iowa City, United States. In Plos Pathog, Mar 2015
A Th2-biased immune response, but not eosinophils specifically, was required for airway hyperreactivity and mucus hypersecretion.
Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease.
Scott et al., London, United Kingdom. In Sci Rep, 2014
We suggest that NEUROD6, ZCCHC17, PPEF1 and MANBAL are potentially implicated in LOAD, with predicted links to calcium signalling and protein mannosylation.
Enhancement of experimental cutaneous leishmaniasis by Leishmania extract: identification of a disease-associated antibody specificity.
Pontes-de-Carvalho et al., Salvador, Brazil. In Bmc Res Notes, 2014
CONCLUSION: A Th2 immune response (IgG1 antibody-producing) against this 116 kDa antigen, therefore, could be associated with susceptibility to severe Leishmania infection.
Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.
Towfic et al., Saint Louis, United States. In Sci Rep, 2014
We next developed algorithms to search hundreds of thousands of Gene Expression Omnibus (GEO) data sets, identifying a link between an AD-associated gene (NEUROD6) and gender.
The CD4 T cell response to respiratory syncytial virus infection.
Review
Varga et al., Iowa City, United States. In Immunol Res, 2014
A Th2 CD4 T cell response has been implicated to be a major contributor in mediating vaccine-enhanced disease.
RNA-Seq data mining: downregulation of NeuroD6 serves as a possible biomarker for alzheimer's disease brains.
Kino et al., Tokyo, Japan. In Dis Markers, 2013
They included downregulation of neuronal differentiation 6 (NeuroD6), a basic helix-loop-helix (bHLH) transcription factor involved in neuronal development, differentiation, and survival in AD brains of both cohorts.
In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice.
GeneRIF
Schwab et al., Göttingen, Germany. In Cereb Cortex, 2012
When injected with tamoxifen, adult NEX-CreERT2 mice induced reporter gene expression exclusively in projection neurons of the neocortex and hippocampus.
JAK and Src tyrosine kinase signaling in asthma.
Review
Alam et al., Denver, United States. In Front Biosci, 2011
A Th2-type immune response dominates the processes that lead to the phenotype of asthma.
Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
GeneRIF
Sanes et al., Cambridge, United States. In Nat Neurosci, 2011
This ssudy demonistrated that Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
NeuroD factors regulate cell fate and neurite stratification in the developing retina.
GeneRIF
Cepko et al., Boston, United States. In J Neurosci, 2011
In the mature retina, NeuroD6 fate-mapped cells include cells in the upper part of the inner nuclear layer (INL), just below the outer plexiform layer, cells in the inner portion of the INL, and cells in the germ-cell layer.
Type 1 autoimmune pancreatitis.
Review
Kawa et al., London, United Kingdom. In Orphanet J Rare Dis, 2010
A Th2-dominant immune reaction and the activation of regulatory T-cells are assumed to be involved in the underlying immune reaction.
NeuroD6 genomic signature bridging neuronal differentiation to survival via the molecular chaperone network.
GeneRIF
Chiaramello et al., Washington, D.C., United States. In J Neurosci Res, 2010
our findings support the notion that NeuroD6 links neuronal differentiation to survival via the network of molecular chaperones and endows the cells with increased stress tolerance.
The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass.
GeneRIF
Chiaramello et al., Washington, D.C., United States. In Asn Neuro, 2009
NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response.
Local cytokine environments drive aneurysm formation in allografted aortas.
Review
Mitchell et al., Boston, United States. In Trends Cardiovasc Med, 2005
A Th2 cytokine milieu was shown to increase selected matrix metalloproteinase (MMP) expression, and interleukin 4 stimulated macrophage production of elastolytic matrix metalloproteinase 12 in vitro.
Can helminth antigens be exploited therapeutically to downregulate pathological Th1 responses?
Review
Cooke et al., Cambridge, United Kingdom. In Curr Opin Investig Drugs, 2004
Results from initial studies were interpreted based upon the Th1/Th2 paradigm: A Th2-polarizing helminth infection correcting a Th1 autoimmune 'imbalance'.
A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle.
Impact
Smale, Los Angeles, United States. In Immunity, 2003
DNase I hypersensitivity assays and phylogenetic analyses previously led to the identification of multiple enhancers in the Th2 cytokine cluster.
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