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Neurogenic differentiation 2

NeuroD2, NDRF, NeuroD-related factor
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FATE, ACID, Grb2, NeuroD6
Papers using NeuroD2 antibodies
Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
Supplier
Nahlé Zaher A. et al., In Acta Neuropathologica, 2008
... Wild type C57-BL6 mice and NeuroD2-SmoA1 mice bearing tumors were administered 10 % dimethyl sulfoxide (DMSO, control), olomoucine (Calbiochem) at 6 mg/kg daily or GW9662 (Cayman Chemicals) at 10 mg/kg daily ...
Papers on NeuroD2
Activation of AKT1/GSK-3β/β-Catenin-TRIM11/Survivin Pathway by Novel GSK-3β Inhibitor Promotes Neuron Cell Survival: Study in Differentiated SH-SY5Y Cells in OGD Model.
New
Ramanathan et al., Coimbatore, India. In Mol Neurobiol, Jan 2016
During differentiation, upregulation of the growth-associated protein 43 (GAP43), neurogenin1 (NGN1), neuronal differentiation 2 (NeuroD2), and tripartite motif containing 11 (TRIM11) genes were observed.
Ethanol-related alterations in gene expression patterns in the developing murine hippocampus.
New
Chai et al., Ansan, South Korea. In Acta Biochim Biophys Sin (shanghai), Aug 2015
Microarray analysis revealed that Nova1, Ntng1, Gal, Neurog2, Neurod2, and Fezf2 gene expressions are altered in the fetal hippocampus.
Chromosome 17 copy number changes in male breast cancer.
New
van Diest et al., Utrecht, Netherlands. In Cell Oncol (dordr), Jun 2015
Two recurrent chromosome 17 amplicons were detected: on 17q12 (encompassing the NEUROD2, HER2, GRB7 and IKZF3 gens) and on 17q23.1 (encompassing the MIR21 and RPS6KB1 genes).
Conversion of MyoD to a neurogenic factor: binding site specificity determines lineage.
New
Tapscott et al., Seattle, United States. In Cell Rep, May 2015
MyoD and NeuroD2, master regulators of myogenesis and neurogenesis, bind to a "shared" E-box sequence (CAGCTG) and a "private" sequence (CAGGTG or CAGATG, respectively).
Genome-wide mapping of copy number variations in patients with both anorectal malformations and central nervous system abnormalities.
New
Reutter et al., Bonn, Germany. In Birth Defects Res A Clin Mol Teratol, Apr 2015
Expression studies in mice suggest that NEUROD2 and RARA, which reside within the newly identified del17q12q21.2
Transcriptional regulation by FOXP1, FOXP2, and FOXP4 dimerization.
New
Crawford et al., Toronto, Canada. In J Mol Neurosci, Feb 2015
In this study, we investigate whether dimerization of FOXP1/2/4 leads to differential expression of ten known FOXP2 target genes (CER1, SFRP4, WISP2, PRICKLE1, NCOR2, SNW1, NEUROD2, PAX3, EFNB3, and SLIT1).
Conversion of fibroblasts to neural cells by p53 depletion.
Yang et al., Saint Louis, United States. In Cell Rep, 2015
p53 binds the promoter of the neurogenic transcription factor Neurod2 and regulates its expression during fibroblast-neuron conversion.
Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation.
Ince-Dunn et al., İstanbul, Turkey. In Bmc Genomics, 2014
RESULTS: In this study, we carried out a ChIP-Seq (chromatin-immunoprecipitation and sequencing) analysis of NEUROD2, an effector transcription factor expressed in lineages of cortical projection neurons during the peak of cortical excitatory neurogenesis.
Differential gene expression in relation to the clinical characteristics of human brain arteriovenous malformations.
Review
Miyamoto et al., Kyoto, Japan. In Neurol Med Chir (tokyo), 2013
The neuron-related genes were NPY, S100A9, NeuroD2, S100Abeta, CAMK2A, SYNPR, CHRM2, and CAMKV.
Naturally occurring Ngn2 promoter activators from Butea superba.
Ishibashi et al., Chiba, Japan. In Mol Biosyst, 2013
30-Methoxydaidzein (3) increased mRNA expression of pro-neural transcriptional factors (Ngn2, Ngn1, NeuroD2), a mature neuron-specific enzyme GAD1 and a pro-neural neurotrophic growth factor neurotrophin 3 (NT3) in C17.2 neural stem cells.
Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions.
Schwab et al., Göttingen, Germany. In J Neurosci, 2013
Here, we have identified basic helix-loop-helix (bHLH) transcription factors Neurod2 and Neurod6 as key regulators of fasciculation and targeted axogenesis in the mouse neocortex.
TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease.
Review
Collier et al., London, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2013
TCF4 is highly expressed in the brain, where plays a role in neurodevelopment, interacting with class II bHLH transcription factors Math1, HASH1, and neuroD2.
Induction of motor neuron differentiation by transduction of Olig2 protein.
Kobatake et al., Yokohama, Japan. In Biochem Biophys Res Commun, 2012
We show that Olig2 protein has the ability to permeate the cell membrane without the addition of a protein transduction domain (PTD), similar to other basic helix-loop-helix transcription factors such as MyoD and NeuroD2.
Induction of neural differentiation by the transcription factor neuroD2.
GeneRIF
Fishman et al., Baltimore, United States. In Int J Dev Neurosci, 2012
Over-expression of neuroD2 (ND2) leads to morphological differentiation of neuroblastoma cells and increased expression of synaptic proteins.
NeuroD2 regulates the development of hippocampal mossy fiber synapses.
GeneRIF
Ghosh et al., San Diego, United States. In Neural Dev, 2011
These experiments identify NeuroD2 as a key transcription factor that regulates the structural and functional differentiation of mossy fiber synapses in vivo.
MicroRNA-mediated conversion of human fibroblasts to neurons.
Impact
Crabtree et al., Stanford, United States. In Nature, 2011
Here we show that expression of miR-9/9* and miR-124 (miR-9/9*-124) in human fibroblasts induces their conversion into neurons, a process facilitated by NEUROD2.
NeuroD factors regulate cell fate and neurite stratification in the developing retina.
GeneRIF
Cepko et al., Boston, United States. In J Neurosci, 2011
NeuroD2 is expressed in amacrine, ganglion, and bipolar cells of the mature mouse retina.
Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample.
GeneRIF
Soyka et al., München, Germany. In Psychiatry Res, 2011
The results of this study did not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence.
Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation.
GeneRIF
Olson et al., Seattle, United States. In Mol Cell Neurosci, 2010
Our study supports a model wherein NeuroD2 induces transcription of neuronal genes and Zfhx1a, which in turn de-represses neuronal differentiation by down-regulating REST, and suppresses competing myogenic fate.
A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation.
Impact
Bonni et al., Boston, United States. In Science, 2009
Cdc20-APC triggered the degradation of the transcription factor NeuroD2 and thereby promoted presynaptic differentiation.
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