gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neurochondrin

Neurochondrin, Norbin, neurochondrin-1, NCDN, SFAP75, neurochondrin-2, KIAA0607
may play an important role in neural plasticity [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: metabotropic glutamate receptor, HAD, Rab5, OUT, tamalin
Papers on Neurochondrin
Evaluation of 12 Novel Molecular Markers for Degenerated Nucleus Pulposus in a Chinese Population.
New
Fan et al., Hangzhou, China. In Spine (phila Pa 1976), Sep 2015
The expression of neurochondrin (NCDN), keratin 8 (KRT8), and matrix Gla protein (MGP) even showed significant changes among subgroups of patients with degenerative disc disease stratified according to the Pfirrmann grading system.
Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice.
New
Flajolet et al., New York City, United States. In Proc Natl Acad Sci U S A, Sep 2015
We previously identified Norbin as a positive regulator of mGluR5 and showed that its expression promotes neurite outgrowth.
Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia.
New
Newell et al., Wollongong, Australia. In Schizophr Res, Aug 2015
In the present study, we investigated whether protein expression of mGluR5, as well as Norbin and Tamalin (modulators of mGluR5 signalling and trafficking), might be altered in the schizophrenia brain, using postmortem samples from the hippocampal CA1 region of schizophrenia subjects and matched controls (n=20/group).
Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation.
New
Newell et al., Wollongong, Australia. In Acta Neuropathol, Jul 2015
We assessed mGluR5 mRNA and protein levels in the dorsolateral prefrontal cortex (DLPFC) using a large cohort of schizophrenia and control subjects (n = 37/group), and additionally measured protein levels of recently discovered mGluR5 endogenous regulators, Norbin (neurochondrin), Tamalin (GRASP-1), and Preso1 (FRMPD4), which regulate mGluR5 localization, internalization and signaling.
A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases/phosphatases in rat brain.
New
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, Feb 2015
This involved changes in signaling kinases and proteases such as protein kinase C beta, neurochondrin (NCDN), calcineurin, extracellular signal-regulated kinsase 1 (ERK1), and mammalian target of rapamycin (MTOR).
Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics.
Matosin et al., Wollongong, Australia. In Bmc Psychiatry, 2013
A number of genetic knockout studies (mGluR5, Norbin, Homer1 etc.) continue to lend support to a role of mGluR5 in the pathology of schizophrenia, providing impetus to explore the regulation of mGluR5 beyond total mGluR5 protein and mRNA levels.
Nanoscopic spine localization of Norbin, an mGluR5 accessory protein.
Brismar et al., Sweden. In Bmc Neurosci, 2013
BACKGROUND: Norbin is a neuron-specific, cytosolic protein that interacts with the metabotropic glutamate receptor 5 (mGluR5) and has a profound impact on mGluR5 signaling.
Imaging brain gene expression profiles by antipsychotics: region-specific action of amisulpride on postsynaptic density transcripts compared to haloperidol.
Iasevoli et al., Napoli, Italy. In Eur Neuropsychopharmacol, 2013
We carried out a molecular imaging study of gene expression after acute administration of haloperidol (0.8 mg/kg), amisulpride (10 or 35 mg/kg), or vehicle, focusing on postsynaptic genes that are key regulators of synaptic plasticity, such as Arc, c-fos, Zif-268, Norbin, Homer.
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Fukata et al., Okazaki, Japan. In J Biol Chem, 2013
Of the 17 candidates, 10 proteins, including 6 synaptic proteins (Syd-1, transmembrane AMPA receptor regulatory protein (TARP) γ-2, TARP γ-8, cornichon-2, Ca(2+)/calmodulin-dependent protein kinase IIα, and neurochondrin (Ncdn)/norbin), one focal adhesion protein (zyxin), two ion channels (TRPM8 and TRPC1), and one G-protein-coupled receptor (orexin 2 receptor), were palmitoylated.
FoxO3a negatively regulates nerve growth factor-induced neuronal differentiation through inhibiting the expression of neurochondrin in PC12 cells.
Zheng et al., Guangzhou, China. In Mol Neurobiol, 2013
DNA microarray analysis and quantitative reverse transcription PCR (RT-PCR) showed that the overexpression of FoxO3a significantly attenuated expression of neurochondrin (NCDN), a neurite outgrowth-related protein, in PC12 cells, while knocking down the expression of FoxO3a had the opposite effect.
Alterations in expression of endometrial genes coding for proteins secreted into the uterine lumen during conceptus elongation in cattle.
Lonergan et al., Dublin, Ireland. In Bmc Genomics, 2012
RESULTS: Of the fourteen candidate genes examined, quantitative real-time PCR analysis revealed the expression of APOA1, ARSA, DCN, LCAT, MUC13, NCDN, NMN, NPNT, NXPH3, PENK, PLIN2 and TINAGL1 was modulated in the endometrium (P<0.05) as the estrous cycle/early pregnancy progressed.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Changes in the molecular phenotype of nucleus pulposus cells with intervertebral disc aging.
Chen et al., Durham, United States. In Plos One, 2011
Among these markers, select neuronal-related proteins (Basp1, Ncdn and Nrp-1), transcriptional factor (Brachyury T), and cell surface receptors (CD24, CD90, CD155 and CD221) were confirmed by real-time PCR and immunohistochemical (IHC) staining for differential expression between IVD tissue regions and among various ages (1, 12 and 21 months).
Norbin: A promising central nervous system regulator.
Flajolet et al., New York City, United States. In Commun Integr Biol, 2010
Norbin, a neurite-outgrowth promoting protein, has been found to interact with and regulate several membrane proteins, including metabotropic glutamate receptor 5 (mGluR5).
Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling.
Impact
GeneRIF
Greengard et al., New York City, United States. In Science, 2010
study reports that Norbin, a neuron-specific protein, physically interacts with mGluR5 in vivo, increases the cell surface localization of the receptor, and positively regulates mGluR5 signaling
Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1.
GeneRIF
Brandt et al., Heidelberg, Germany. In Biochem Biophys Res Commun, 2008
Neurochondrin is a novel Dia1 interacting protein.
Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.
GeneRIF
Fukamizu et al., Tsukuba, Japan. In J Biol Chem, 2005
In mouse, the encoded protein is a negative regulator of Ca/calmodulin-dependent protein kinase II phosphorylation and is essential for the spatial learning process.
Expression of neurochondrin in the developing and adult mouse brain.
GeneRIF
Wurst et al., München, Germany. In Dev Genes Evol, 2004
Neurochondrin expression pattern in the developing and adult brain.
share on facebooktweetadd +1mail to friends