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Neurexophilin 1

Neurexophilin, neurexophilin 1, neurophilin, NXPH1
a neuronal protein that binds neurexin l alpha [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: SET, ACID, Neuropeptide, TOP, CAN
Papers on Neurexophilin
Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity.
New
Zhang et al., Shanghai, China. In Cell Res, Jan 2016
Large DRG neurons are categorized into four types, including neurexophilin 1-expressing MHNs and mechanical nociceptors (MNs) expressing BAI1-associated protein 2-like 1 (Baiap2l1).
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma.
New
Vandesompele et al., Gent, Belgium. In Oncotarget, Jan 2016
In total, 5 individual MSP assays (located in CCDC177, NXPH1, lnc-MRPL3-2, lnc-TREX1-1 and one on a region from chromosome 8 with no further annotation) predict event-free survival and 4 additional assays (located in SPRED3, TNFAIP2, NPM2 and CYYR1) also predict overall survival.
Acid-responsive PEGylated doxorubicin prodrug nanoparticles for neuropilin-1 receptor-mediated targeted drug delivery.
New
Kong et al., Tianjin, China. In Colloids Surf B Biointerfaces, Jan 2016
Then it was functionalized with a tumor-penetrating peptide, Cys-Arg-Gly-Asp-Lys (CRGDK), providing the prodrug nanoparticles with the specific binding ability to neurophilin-1 receptor.
Identification of Neurexophilin 3 as a Novel Supportive Factor for Survival of Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors.
New
Takahashi et al., Kyoto, Japan. In Stem Cells Transl Med, Aug 2015
We report that a secreted peptide, neurexophilin 3 (NXPH3), supports the survival of mouse induced pluripotent stem cell-derived (iPSC-derived) dopaminergic (DA) neurons in vitro and in vivo.
[The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars].
New
Khusnutdinova et al., In Genetika, Jul 2015
In this paper we investigated 48 polymorphic variants of genes of the neurotrophins and neurexins family (BDNF, NTRK2, NTRK3, NGF, NXPH1, and NRXN1) in Russian and Tatar cases and in a control group living in the Republic of Bashkortostan.
Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.
Boeckxstaens et al., Leuven, Belgium. In Gut, 2014
(1.03 to 3.01)) and rs2349775-NXPH1 with IBS-D (ORexploratory=1.28
Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation.
Vohl et al., Québec, Canada. In J Lipid Res, 2014
Thirteen loci had frequency differences between responders and nonresponders (P < 1 × 10(-5)), including SNPs in or near IQCJ-SCHIP1, MYB, NELL1, NXPH1, PHF17, and SLIT2 genes.
Dynamic expression of neurexophilin1 during zebrafish embryonic development.
Houart et al., London, United Kingdom. In Gene Expr Patterns, 2013
Neurexophilin 1 (Nxph1) is a specific endoligand of α-neurexins that is essential for trans-synaptic activation.
Neurexophilin 1 gene polymorphism in chickens and its variation among species.
Tang et al., Wuhan, China. In Biochem Genet, 2013
Neurexophilin 1 (nxph1) has been considered a potential candidate marker for sperm storage in chicken sperm storage tubules.
Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study.
Arnett et al., Saint Louis, United States. In Lipids, 2013
NXPH1 (7p22), and SLC24A4 (14q32.12) in association with NMR-LDLs; HOMER1 (5q14.2),
Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.
Gerhauser et al., Heidelberg, Germany. In Faseb J, 2012
In tumors, median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were ≥30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
Tusié-Luna et al., Mexico. In Diabetes, 2012
Twenty-four single nucleotide polymorphisms (SNPs) in or near genes (KCNJ11, PPARG, TCF7L2, SLC30A8, HHEX, CDKN2A/2B, CDKAL1, IGF2BP2, ARHGEF11, JAZF1, CDC123/CAMK1D, FTO, TSPAN8/LGR5, KCNQ1, THADA, ADAMTS9, NOTCH2, NXPH1, RORA, UBQLNL, and RALGPS2) were genotyped in Mexican Mestizos.
Near-infrared Dye(®)800CW–conjugated disulfide-based cyclic RGD peptide c(CRGDKGPDC) and its DOTA analog
Review
Chopra, Bethesda, United States. In Unknown Journal, 2012
A disulfide-based cyclic RGD peptide, c(CRGDKGPDC) (iRGD), which interacts with the integrin and neurophilin-1 receptors, was shown to facilitate deeper penetration of imaging agents (5) and anticancer drugs (6) compared with the original RGD peptide.
Genome-wide CpG island profiling of intraductal papillary mucinous neoplasms of the pancreas.
Goggins et al., Baltimore, United States. In Clin Cancer Res, 2012
Several genes (BNIP3, PTCHD2, SOX17, NXPH1, EBF3) were significantly more likely to be methylated in IPMNs with high-grade than with low-grade dysplasia.
Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.
GeneRIF
Broxmeyer et al., Indianapolis, United States. In Blood, 2011
results demonstrate the presence and function of a regulated signaling axis in hematopoiesis centered on NRXN1alpha and its modulation by DAG1 and NXPH1
Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.
GeneRIF
Leal et al., Islamabad, Pakistan. In Hum Hered, 2010
Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified.
Copy number variants in extended autism spectrum disorder families reveal candidates potentially involved in autism risk.
Pericak-Vance et al., Miami, United States. In Plos One, 2010
These findings provide further evidence for the involvement of ICA1 and NXPH1 on 7p21.3 in ASD susceptibility and highlight novel ASD candidates, including CHL1, FGFBP3 and POUF41.
Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb.
GeneRIF
Key et al., Brisbane, Australia. In Int J Dev Biol, 2001
In rat, the secreted ligand for alpha-neurexin, neurexophilin 1, is expressed in the postnatal olfactory bulb.
Structure and evolution of neurexophilin.
GeneRIF
Südhof et al., Dallas, United States. In J Neurosci, 1996
In rat, neurexophilin 1 forms a very tight complex with neurexin I alpha.
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