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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Netrin G1

netrin-G1, netrin-G2, NTNG1, NTNG2
Netrin G1 (NTNG1) belongs to a conserved family of proteins that act as axon guidance cues during vertebrate nervous system development (Nakashiba et al., 2000 [PubMed 10964959]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, OUT, ACID, DCC
Papers on netrin-G1
Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.
New
Itohara et al., Wako, Japan. In Mol Brain, Dec 2015
We found that two netrin-G paralogs that recently diverged in evolution, netrin-G1 and netrin-G2 (gene symbols: Ntng1 and Ntng2, respectively), were responsible for complementary behavioral functions.
Replication of NTNG1 association in schizophrenia.
Quadri et al., Tucson, United States. In Psychiatr Genet, 2014
This is a case-control study of the association of NTNG1 subtypes with schizophrenia among a group of individuals from a Caucasian population.
Netrin-G/NGL complexes encode functional synaptic diversification.
Itohara et al., Wako, Japan. In J Neurosci, 2014
Here, we use netrin-G-KO and NGL-KO mice to reveal that netrin-G1/NGL1 and netrin-G2/NGL2 interactions specify excitatory synapses in independent hippocampal pathways.
A genome-wide association study of calf birth weight in Holstein cattle using single nucleotide polymorphisms and phenotypes predicted from auxiliary traits.
Swalve et al., Halle, Germany. In J Dairy Sci, 2014
Several SNP related to growth and development were found among the 25 SNP with the largest effects, including markers located within or near (≤ 100 kbp) ABCA12, FLRT2, LHX4, MAP3K5, NRAC, NTNG1, PIGN, and ZNF75A.
FUS-mediated alternative splicing in the nervous system: consequences for ALS and FTLD.
Review
Edbauer et al., München, Germany. In J Mol Med (berl), 2013
Several groups have shown that FUS binds broadly to many transcripts in the brain and have also identified a plethora of putative splice targets; however, only ABLIM1, BRAF, Ewing sarcoma protein R1 (EWSR1), microtubule-associated protein tau (MAPT), NgCAM cell adhesion molecule (NRCAM), and netrin G1 (NTNG1) have been identified in at least three of four studies.
Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.
Itohara et al., Wako, Japan. In Mol Brain, 2013
The Ntng1 and Ntng2 genes, encoding axonal membrane adhesion proteins netrin-G1 and netrin-G2, respectively, are paralogs that have evolved in vertebrates and are expressed in distinct neuronal subsets in a complementary manner.
Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.
Kim et al., Taejŏn, South Korea. In J Cell Sci, 2013
Here, we report that the initial trans-synaptic adhesion mediated by presynaptic netrin-G1 and postsynaptic NGL-1 (netrin-G1 ligand-1) induces a cis interaction between netrin-G1 and the receptor protein tyrosine phosphatase LAR (leukocyte antigen-related), and that this promotes presynaptic differentiation.
Molecular and cell biological effects of 3,5,3'-triiodothyronine on progenitor cells of the enteric nervous system in vitro.
Just et al., Tübingen, Germany. In Stem Cell Res, 2013
Interestingly, T3 regulated the expression of netrin G1 and endothelin 3, two guidance molecules that are involved in human enteric dysganglionoses.
Mosaic small supernumerary marker chromosome 1 at amniocentesis: prenatal diagnosis, molecular genetic analysis and literature review.
Review
Wang et al., Taipei, Taiwan. In Gene, 2013
We discuss the genotype-phenotype correlation of the involved genes of ALX3, RBM15, NTNG1, SLC25A24, GPSM2, TBX15 and NOTCH2 in this case.
Transcriptome profile at different physiological stages reveals potential mode for curly fleece in Chinese tan sheep.
Fang et al., Beijing, China. In Plos One, 2012
The hair-related important differentially expressed genes (SPINK4, FGF21, ESRα, EphA3, NTNG1 and GPR110) were confirmed by qPCR analysis.
CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.
Impact
Broccoli et al., Milano, Italy. In Nat Cell Biol, 2012
Mutations of the cyclin-dependent kinase-like 5 (CDKL5) and netrin-G1 (NTNG1) genes cause a severe neurodevelopmental disorder with clinical features that are closely related to Rett syndrome, including intellectual disability, early-onset intractable epilepsy and autism.
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.
Impact
Eichler et al., Seattle, United States. In Nature, 2012
In proband exomes, recurrent protein-altering mutations were observed in two genes: CHD8 and NTNG1.
Crystal structure of the ligand binding domain of netrin G2.
GeneRIF
Shapiro et al., New York City, United States. In J Mol Biol, 2012
the crystal structure for a fragment comprising the LN domain and domain LE1 of netrin G2 by sulfur single-wavelength anomalous diffraction phasing and refined it to 1.8 A resolution was determined.
Positive association between NTNG1 and schizophrenia in Chinese Han population.
GeneRIF
Liu et al., Shenyang, China. In J Genet, 2011
Genotype and allele frequencies of single nucleotide polymorphisms on NTNG1 are significantly associated with schizophrenia.
Abnormal expression of netrin-G2 in temporal lobe epilepsy neurons in humans and a rat model.
GeneRIF
Wang et al., Chongqing, China. In Exp Neurol, 2010
Netrin-g2 is involved in the pathophysiology of epilepsy and are consistent with the hypothesis that this protein may participate in the abnormal development of synapses and in neuron migration
The NGL family of leucine-rich repeat-containing synaptic adhesion molecules.
Review
Kim et al., Taejŏn, South Korea. In Mol Cell Neurosci, 2009
The three known members of the NGL family, NGL-1, NGL-2, and NGL-3, are mainly localized to the postsynaptic side of excitatory synapses, and interact with the presynaptic ligands, netrin-G1, netrin-G2, and LAR, respectively.
Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.
Review
Isacson et al., Belmont, United States. In Trends Neurosci, 2009
The axon-guidance-pathway genes DCC, EPHB1, NTNG1, SEMA5A and SLIT3 were represented by SNPs predicting PD outcomes.
Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness.
GeneRIF
Lanthorn et al., The Woodlands, United States. In Genes Brain Behav, 2008
Mice in which netrin-G2 has been genetically inhibited do not startle to an acoustic stimulus, but otherwise perform normally through a behavioral test battery. There were no inner ear structural abnormalities.
Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury.
GeneRIF
Ramesh et al., United States. In Am J Physiol Renal Physiol, 2008
value of netrin-1 as a biomarker of renal injury by analyzing urinary excretion following ischemia-reperfusion.
Netrins and their receptors.
Review
Kennedy et al., Montréal, Canada. In Adv Exp Med Biol, 2006
The netrin-G proteins bind NGLs (netrin G ligands), single pass transmembrane proteins unrelated to either DCC or the UNC5 homologues.
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