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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Netrin 4

netrin-4, NTN4, beta-Netrin
NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) [PubMed 11038171].[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: netrin-1, Akt, AGE, DCC, UNC5B
Papers on netrin-4
The Prediction of the Expected Current Selection Coefficient of Single Nucleotide Polymorphism Associated with Holstein Milk Yield, Fat and Protein Contents.
Kim et al., Seoul, South Korea. In Asian-australas J Anim Sci, Jan 2016
They are phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2) and ADAM metallopeptidase domain 12 (ADAM12).
Lack of netrin-4 modulates pathologic neovascularization in the eye.
Joussen et al., Berlin, Germany. In Sci Rep, Dec 2015
Netrin-4 displays pathologic roles in tumorigenesis and neovascularization.
Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.
Lennon et al., Manchester, United Kingdom. In J Am Soc Nephrol, Dec 2015
Among the variation, we observed changes in netrin 4, fibroblast growth factor 2, tenascin C, collagen 1, meprin 1-α, and meprin 1-β.
Inhibition of human placental endothelial cell proliferation and angiogenesis by netrin-4.
de Mazancourt et al., Montigny-le-Bretonneux, France. In Placenta, Nov 2015
INTRODUCTION: Netrin-4 is a secreted member of the laminin-related protein family, known to be involved in axonal guidance and endothelial cell survival, proliferation, and migration.
Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data.
Wijsman et al., Seattle, United States. In Genes Brain Behav, Nov 2015
We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants, and for four genes (SLC8A3, SLC19A3, MADD and LRRK2) with multiple rare-associated variants that have a plausible biological function related to AD.
MiR-17-92 cluster promotes hepatocarcinogenesis.
Wu et al., New Orleans, United States. In Carcinogenesis, Oct 2015
By analyzing the miRNA and mRNA sequencing data from the 312 hepatocellular cancer patients available from the TCGA database, we observed that the expression levels of the miR-17-92 cluster members and host gene in the tumor tissues are negatively correlated with several target genes, including CREBL2, PRRG1, NTN4.
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.
Vachon et al., Australia. In Cancer Res, Jul 2015
There were associations between rs6001930 (MKL1) and both adjusted absolute dense and nondense areas, and between rs17356907 (NTN4) and adjusted absolute nondense area.
Tumor-specific mutations in low-frequency genes affect their functional properties.
French et al., Rotterdam, Netherlands. In J Neurooncol, May 2015
NTN4 and MAGEH1) showed that the mutation affects the subcellular localization of the protein (n = 2/12).
Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer.
Liu et al., Shanghai, China. In Oncotarget, May 2015
Netrin-4 (Ntn4) is a laminin-related secreted molecule found to regulate tumor progression and metastasis.
Volumetric mammographic density: heritability and association with breast cancer susceptibility loci.
Czene et al., Stockholm, Sweden. In J Natl Cancer Inst, 2014
We also observed associations of rs9383938 (ESR1) and rs2046210 (ESR1) with the absolute dense volume (P = 2.6 × 10(-4) and 4.6 × 10(-4), respectively), and rs6001930 (MLK1) and rs17356907 (NTN4) with the absolute nondense volume (P = 6.7 × 10(-6) and 8.4 × 10(-5), respectively).
Therapeutic effects of topical netrin-4 in a corneal acute inflammatory model.
Liu et al., Xiamen, China. In Int J Ophthalmol, 2014
AIM: To evaluate the therapeutic effect of netrin-4 on the early acute phase of inflammation in the alkali-burned eye.
High Expression of Three-Gene Signature Improves Prediction of Relapse-Free Survival in Estrogen Receptor-Positive and Node-Positive Breast Tumors.
Padigaru et al., Mumbai, India. In Biomark Insights, 2014
In our previous study, we identified a group of seven genes (GATA3, NTN4, SLC7A8, ENPP1, MLPH, LAMB2, and PLAT) that show elevated messenger RNA (mRNA) expression levels in ERα (+) breast cancer patient samples.
Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats.
Liu et al., Xiamen, China. In Plos One, 2014
Netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors.
Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion.
Yamamoto et al., Suita, Japan. In Proc Natl Acad Sci U S A, 2014
Here, we demonstrate that the netrin family member netrin-4 (NTN4) contributes to activity-dependent thalamocortical (TC) axon branching.
Netrins and their roles in placental angiogenesis.
de Mazancourt et al., Montigny-le-Bretonneux, France. In Biomed Res Int, 2013
Among all netrins examined, netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors.
Netrin-4 promotes glioblastoma cell proliferation through integrin β4 signaling.
Hyytiäinen et al., Helsinki, Finland. In Neoplasia, 2012
glioma cells reduce netrin-4 expression to decrease its inhibitory effects.
Netrin-4 activates endothelial integrin {alpha}6{beta}1.
Li et al., Salt Lake City, United States. In Circ Res, 2011
The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells.
Netrin-4 is upregulated in breast carcinoma effusions compared to corresponding solid tumors.
Davidson et al., Oslo, Norway. In Diagn Cytopathol, 2011
Netrin-4 is upregulated in breast carcinoma effusions compared to corresponding solid tumors
Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis.
Pocard et al., Paris, France. In Am J Pathol, 2011
NT-4 overexpression decreases tumor growth and carcinomatosis, probably via an antiangiogenic effect
Netrin-4 induces lymphangiogenesis in vivo.
Li et al., Salt Lake City, United States. In Blood, 2010
In vivo, Netrin-4 induces growth of lymphatic and blood vessels in the skin of transgenic mice.
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