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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Netrin 1

netrin-1
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DCC, CAN, UNC5B, V1a, Midline
Papers on netrin-1
Direct measurement of oscillatory RhoA activity in embryonic cortical neurons stimulated with the axon guidance cue netrin-1 using FRET.
New
Lamarche-Vane et al., Montréal, Canada. In Biol Cell, Feb 2016
Signaling downstream of the axon guidance cue netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) triggers the activation of Rac1 and the inhibition of RhoA to promote axon outgrowth.
Netrin-1 prevents the development of cardiac hypertrophy and heart failure.
New
Zhu et al., Lanzhou, China. In Mol Med Report, Feb 2016
UNASSIGNED: The aim of the present study was to examine whether netrin-1 is involved in the development of cardiac hypertrophy, induced by pressure overload.
[Diagnostic values of urinary netrin-1 and kidney injury molecule-1 for acute kidney injury induced by neonatal asphyxia].
New
Chen et al., Shihezi, China. In Zhongguo Dang Dai Er Ke Za Zhi, Jan 2016
OBJECTIVE: To investigate the values of urinary netrin-1 and kidney injury molecule-1 (KIM-1) in the early diagnosis of acute kidney injury (AKI) induced by neonatal asphyxia.
p120RasGAP mediates netrin-1-induced cortical axon outgrowth and guidance.
New
Lamarche-Vane et al., Canada. In J Biol Chem, Jan 2016
UNASSIGNED: The receptor Deleted in Colorectal Cancer (DCC) mediates attraction of growing axons to netrin-1 during brain development.
Lack of netrin-4 modulates pathologic neovascularization in the eye.
New
Joussen et al., Berlin, Germany. In Sci Rep, Dec 2015
Netrin-4, but not netrin-1 mRNA expression, increased in response to relative hypoxia and recovered to normal levels at the end of blood vessel formation.
Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit?
Review
New
Passacquale et al., London, United Kingdom. In Cardiovasc Res, Oct 2015
Over recent years, it has become apparent that netrin-1 may additionally be involved in the underlying pathology of several multisystem diseases, making it an attractive potential therapeutic target.
Signaling mechanism of the netrin-1 receptor DCC in axon guidance.
Review
New
Wang et al., Beijing, China. In Prog Biophys Mol Biol, Sep 2015
It was originally identified as a prognostic tumor marker and then subsequently found to be a receptor for netrin-1.
Axon guidance factor netrin-1 and its receptors regulate angiogenesis after cerebral ischemia.
Review
Yu et al., Guangzhou, China. In Neurosci Bull, 2014
In this review, we focus on netrin-1, which has been shown to be involved in axon migration and angiogenesis, which are required for recovery after cerebral ischemia.
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
Impact
Nikolov et al., New York City, United States. In Science, 2014
Deleted in colorectal cancer (DCC) is a well-established netrin-1 receptor mediating attractive responses.
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
Impact
Moore et al., New York City, United States. In Nat Med, 2014
Here we show that the neuroimmune guidance cue netrin-1 is highly expressed in obese but not lean adipose tissue of humans and mice, where it directs the retention of macrophages.
Netrins and their roles in placental angiogenesis.
Review
de Mazancourt et al., Montigny-le-Bretonneux, France. In Biomed Res Int, 2013
Among all netrins examined, netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors.
Guidance cue netrin-1 and the regulation of inflammation in acute and chronic kidney disease.
Review
Ramesh et al., Augusta, United States. In Mediators Inflamm, 2013
The ability of the guidance molecule netrin-1 to repulse or abolish attraction of neuronal cells expressing the UNC5B receptor makes it an attractive candidate for the regulation of inflammatory cell migration.
Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.
Impact
Sapieha et al., Montréal, Canada. In Cell Metab, 2013
Our findings demonstrate that the endoribonuclease IRE1α degrades the classical guidance cue netrin-1.
Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth.
GeneRIF
Mehlen et al., Lyon, France. In J Biol Chem, 2012
Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth.
Netrin-1 attracts axons through FAK-dependent mechanotransduction.
GeneRIF
Sheetz et al., New York City, United States. In J Neurosci, 2012
This study demonistrated that Netrin-1 attracts axons through FAK-dependent mechanotransduction.
Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
GeneRIF
Liu et al., Toledo, United States. In J Biol Chem, 2012
knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1
Netrin-1 simultaneously suppresses corneal inflammation and neovascularization.
GeneRIF
Liu et al., Xiamen, China. In Invest Ophthalmol Vis Sci, 2012
Netrin-1 and its receptor UNC5B were expressed in normal rat corneal epithelium and stromal cells, and their expression decreased after corneal alkali burn.
Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.
Impact
Berns et al., Amsterdam, Netherlands. In Nature, 2012
DCC belongs to the family of netrin 1 receptors, which function as dependence receptors as they control survival or apoptosis depending on ligand binding.
The ins and outs of inflammatory cells in atheromata.
Impact
Libby et al., Boston, United States. In Cell Metab, 2012
Recent work in Nature Immunology (van Gils et al., 2012) demonstrates that the neuroimmune guidance cue netrin-1 can retain macrophages in atherosclerotic lesions, thus promoting atherosclerosis.
[Netrin-1 protein expression in gastric cancer and its correlation with clinicopathologic features and prognosis].
GeneRIF
Han et al., Hangzhou, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2011
netrin-1 protein expression may be related to tumorigenesis and tumor progression of gastric cancer.
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