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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: Neuropilin-1, FasT, Angpt1, angpt2, ACID
Papers on NETO2
Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. Results from a prospective study.
Cillo et al., Modena, Italy. In Gut, Mar 2015
A five-gene transcriptomic hepatic signature including angiopoietin-2 (ANGPT2), delta-like ligand 4 (DLL4), neuropilin (NRP)/tolloid (TLL)-like 2 (NETO2), endothelial cell-specific molecule-1 (ESM1), and nuclear receptor subfamily 4, group A, member 1 (NR4A1) was found to accurately identify rapidly growing HCCs of the first quartile (ROC AUC: 0.961; 95% CI 0.919 to 1.000; p<0.0001) and to be an independent factor for mortality (HR: 3.987; 95% CI 1.941 to 8.193, p<0.0001).
Upregulation of NETO2 expression correlates with tumor progression and poor prognosis in colorectal carcinoma.
Gao et al., Luoyang, China. In Bmc Cancer, 2014
BACKGROUND: Neuropilin and tolloid-like 2 (NETO2) has been found to be overexpressed in different human cancers, but its expression pattern and clinical relevance in colorectal carcinoma (CRC) remains unknown.
Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia.
King et al., Seattle, United States. In Am J Hum Genet, 2013
Four of 124 affected individuals and zero of 290 control individuals harbored such events (p = 0.002); a 47 kb duplication disrupted MATK and ZFR2, a 58 kb duplication disrupted PLEKHD1 and SLC39A9, a 121 kb duplication disrupted DNAJA2 and NETO2, and a 150 kb deletion disrupted MAP3K3 and DDX42.
Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function.
Swanson et al., Chicago, United States. In Nat Rev Neurosci, 2012
Recently, however, the neuropilin and tolloid-like 1 (NETO1) and NETO2 proteins were identified as auxiliary kainate receptor subunits that shape both the biophysical properties and synaptic localization of these receptors.
[Increase in NETO2 gene expression is a potential molecular genetic marker in renal and lung cancers].
Kudriavtseva et al., In Genetika, 2012
A bioinformatic screening of transcriptomic databases identified the NETO2 gene as a new potential promising marker of renal cancer.
Juxtaposition of heterochromatic and euchromatic regions by chromosomal translocation mediates a heterochromatic long-range position effect associated with a severe neurological phenotype.
Larizza et al., Cusano Milanino, Italy. In Mol Cytogenet, 2011
The expression of the genes located on both sides of the translocation were tested by means of real-time PCR and three, all located on der(16), were found to be variously perturbed: the euchromatic gene NETO2/BTCL2 was silenced, whereas VPS35 and SHCBP1, located within the major heterochromatic block of chromosome 16q11.2,
Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) proteins.
Swanson et al., Chicago, United States. In J Neurosci, 2011
The neuropilin and tolloid-like proteins (NETO) 1 and NETO2, two closely related CUB domain-containing integral membrane proteins, were identified recently as auxiliary proteins that slowed GluK2a kainate receptor current kinetics without impacting receptor membrane localization.
Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling.
Kozakewich et al., Boston, United States. In Am J Pathol, 2009
Relative to normal placental vessels, proliferating hemangiomas were characterized by increased expression of genes involved in endothelial-pericyte interactions, such as angiopoietin-2 (ANGPT2), jagged-1 (JAG1), and notch-4 (NOTCH4), as well as genes involved in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing receptor (plexinC1), and an ephrin receptor (EPHB3).
A transmembrane accessory subunit that modulates kainate-type glutamate receptors.
Tomita et al., New Haven, United States. In Neuron, 2009
Rat neto2 plays a role in glutamate signaling in the brain by modulating the function of kainate receptors.
Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF.
Caceres et al., Edinburgh, United Kingdom. In Plos One, 2007
We demonstrate that ectopic expression of SF2/ASF regulates the splicing and polysome association of transcripts derived from the SFRS1, PABC1, NETO2 and ENSA genes.
Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2.
Steeg et al., Bethesda, United States. In Cancer Res, 2007
Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression.
Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system.
Endo et al., Tokyo, Japan. In Brain Res Dev Brain Res, 2004
Btcl2 mRNA was observed restrictively in brain throughout embryonic and postnatal stages; expressed in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation.
Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Henzel et al., San Francisco, United States. In Protein Sci, 2004
Determination of the neuropilin and tolloid-like protein 2 signal peptide cleavage site by N-terminal sequencing.
A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain.
Weber et al., Würzburg, Germany. In Gene, 2002
The mouse and human genes, termed NETO1 (neuropilin and tolloid like-1), display sequence identities of 87% at the nucleotide and 95% at the protein level.
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