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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

V-ets erythroblastosis virus E26 oncogene homolog 1

NET, Elk-1, Ets-1
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: SPINK5, CAN, HAD, somatostatin, V1a
Papers using NET antibodies
Modulation of prostate cancer cell gene expression by cell-to-cell contact with bone marrow stromal cells or osteoblasts
Akao Yukihiro et al., In Journal of Molecular Histology, 2008
... Antibodies against human TSG101, CD9, CD81, PTHrP, Ets1, GAPDH, and mouse Ets1 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
Stubbs Lisa, In PLoS Genetics, 2006
... cells (ATCC) using either a mouse monoclonal antibody recognizing GABPα, sc-28312, or a polyclonal rabbit antibody against ETS1, sc-350 (Santa Cruz Biotechnology).
“The transcriptional landscape of the mammalian genome.”
van Veen Hendrik W., In PLoS ONE, 2004
... anti-hDAT-EL2 antibody AB5802 and rabbit anti-hDAT-Ct antibody AB1766 were purchased from Chemicon (Temecula, CA), anti-human NET mouse monoclonal antibody NET17-1 from MAb Technologies (Stone Mountain, GA), anti-HA antibody from MBL (Nagoya, Japan), and anti-His ...
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling
Lowenstein Charles J. et al., In The Journal of Experimental Medicine, 2002
... Antibodies to NF-κB p65, IκBα, NOS2 (M-19), MKP-1 (V-15), MEK1/2, pan acetyl-K (C2), p300 (C20), Elk-1, and ERα were purchased from Santa Cruz Biotechnology, Inc ...
Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the–219T allelic form modulates APOE promoter activity.
Creighton Chad, In PLoS ONE, 2002
... for Sp1, Ets-1, STAT3, dominant-negative mutant of Sp1 (Sp1DN) (amino acids 592–758), dominant-negative mutant of Ets-1 (Ets-1DN) (amino acids 306–441), STAT3ΔN (amino acids 162–770), and STAT3β were PCR amplified from their cDNAs and subcloned into the pCMV-HA vector (Clontech, USA) ...
Papers on NET
Enhanced MAPK signaling drives ETS1-mediated induction of miR-29b leading to downregulation of TET1 and changes in epigenetic modifications in a subset of lung SCC.
Chresta et al., Macclesfield, United Kingdom. In Oncogene, Feb 2016
Focusing on the immune-evasion subtype, bioinformatic analysis of microRNA promoters revealed enrichment for binding sites for the MAPK-driven ETS1 transcription factor.
Phosphatidylserine enhances IKBKAP transcription by activating the MAPK/ERK signaling pathway.
Ast et al., Tel Aviv-Yafo, Israel. In Hum Mol Genet, Feb 2016
Analysis of ChIP-seq results of the IKBKAP promoter region revealed binding of the transcription factors CREB and ELK1, which are regulated by the MAPK/ERK signaling pathway.
Age-related changes in prefrontal norepinephrine transporter density: the basis for improved cognitive flexibility after low doses of atomoxetine in adolescent rats.
McGaughy et al., Philadelphia, United States. In Brain Res, Feb 2016
A second study in adolescent rats investigated changes in norepinephrine transporter (NET) and dopamine beta hydroxylase (DBH) density in five functionally distinct sub-regions of the prefrontal cortex: infralimbic, prelimbic, anterior cingulate, medial and lateral orbitofrontal cortices.
A perspective on NETosis in diabetes and cardiometabolic disorders.
Avogaro et al., Padova, Italy. In Nutr Metab Cardiovasc Dis, Jan 2016
In fact, in vitro induction of NETosis and circulating concentrations of NET-associated proteins appear to be enhanced in diabetic patients.
Advances in Peptide Receptor Radionuclide Therapy.
Ezziddin et al., Essen, Germany. In Semin Nucl Med, Jan 2016
The approach of combining cytotoxic or radiosensitizing drugs with the PRRT agents seems to trigger a major boost of efficacy in pancreatic NET.
Purification of Lamins and Soluble Fragments of NETs.
Schirmer et al., Edinburgh, United Kingdom. In Methods Enzymol, Dec 2015
This chapter describes strategic considerations and protocols to facilitate biochemical studies of lamins and NET proteins in vitro.
Neoadjuvant endocrine treatment in early breast cancer: An overlooked alternative?
Trinh et al., Antwerp, Belgium. In Eur J Surg Oncol, Dec 2015
UNASSIGNED: During the last decade neoadjuvant endocrine therapy (NET) has moved from being reserved for elderly and frail non-chemotherapy candidates to a primary systemic modality in selected patients with hormone sensitive breast cancer.
Gastrointestinal neuroendocrine tumors: Searching the optimal treatment strategy-A literature review.
Stefano et al., Ancona, Italy. In Crit Rev Oncol Hematol, Dec 2015
The multi-TKI sunitinib and of the mTOR-inhibitor everolimus are efficacy for metastatic pancreatic NET (P-NET) treatment.
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
Tergaonkar et al., Singapore, Singapore. In Nat Cell Biol, Oct 2015
Transcriptional reactivation of TERT, the catalytic subunit of telomerase, is necessary for cancer progression in about 90% of human cancers.
Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing.
Proudfoot et al., Lisbon, Portugal. In Cell, May 2015
Consequently, we have developed native elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which generates single-nucleotide resolution, nascent transcription profiles.
Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution.
Churchman et al., Boston, United States. In Cell, May 2015
We developed a simple and powerful approach for performing native elongating transcript sequencing (NET-seq) in human cells that globally maps strand-specific Pol II density at nucleotide resolution.
Association between polymorphism of the norepinephrine transporter gene rs2242446 and rs5669 loci and depression disorders.
Yan et al., Shanghai, China. In Int J Clin Exp Med, 2014
OBJECTIVE: To explore the association between polymorphism of the norepinephrine transporter (NET) gene rs2242446 and rs5669 loci and depression in Chinese Han population.
Expression of DKK1 and β-catenin in epidermal neoplasms and their correlation.
Chen et al., Chongqing, China. In Int J Clin Exp Med, 2014
METHODS: Immunohistochemical staining was applied to detect the expression of DKK1 and β-catenin in tissue samples of 19 cases of seborrheic keratosis (SK), 16 cases of actinic keratosis (AK), 24 cases of Bowen's disease (BD), 25 cases of cutaneous squamous cell carcinoma (SCC), and 22 cases of normal epidermal tissue (NET).
Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.
Kaelin et al., Boston, United States. In Cancer Cell, 2014
We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein, which is an ubiquitin ligase component, leading to their destruction.
Interactions between RNA polymerase and the "core recognition element" counteract pausing.
Nickels et al., United States. In Science, 2014
Here, by use of native elongating transcript sequencing (NET-seq) and a variant of NET-seq that enables analysis of mutant RNAP derivatives in merodiploid cells (mNET-seq), we analyze transcriptional pausing genome-wide in vivo in Escherichia coli.
Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome.
El-Osta et al., Melbourne, Australia. In Arterioscler Thromb Vasc Biol, 2012
chromatin-modifying events associated with SLC6A2 gene suppression may constitute a mechanism of postural tachycardia syndrome
Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1.
Kee et al., Chicago, United States. In Immunity, 2012
ETS1 regulates a broad gene expression program in NK cells that promotes target cell recognition while limiting cytokine-driven activation.
Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370.
Akao et al., Nara, Japan. In Febs Lett, 2012
miR-370 directly regulates BMP-2 and Ets1 expression, at the translational level, during BMP-2-stimulated cell differentiation.
Expression of protein kinase Cα and the MZF-1 and elk-1 transcription factors in human bladder transitional cell carcinoma cells.
Hsu et al., China. In Chin J Physiol, 2012
Although the findings showed elevated expression of Elk-1 and PKCalpha in 5637 cells, the regulator of PKCalpha in bladder cancer cells is yet to be determined.
ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes.
Sharrocks et al., Manchester, United Kingdom. In Plos Genet, 2011
This is demonstrated for the unique binding mode where a novel role for ELK1 in controlling cell migration is revealed.
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