Deletion of the App-Runx1 region in mice models human partial monosomy 21.
Illkirch-Graffenstaden, France. In Dis Model Mech, Jun 2015
Further studies confirmed a gene dosage effect in the Ms5Yah hippocampus, and pinpointed disruptions of pathways related to cell adhesion (involving App, Cntnap5b, Lgals3bp, Mag, Mcam, Npnt, Pcdhb2, Pcdhb3, Pcdhb4, Pcdhb6, Pcdhb7, Pcdhb8, Pcdhb16 and Vwf).
Novel biomarkers indicating repair or progression after acute kidney injury.
Pittsburgh, United States. In Curr Opin Nephrol Hypertens, 2015
Specifically, the role of novel biomarkers including neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and nephronectin (NPNT) in the recovery process has been studied, but it has not reached the point of widespread clinical implementation.
Signaling from the podocyte intercellular junction to the actin cytoskeleton.
Philadelphia, United States. In Semin Nephrol, 2012
This review focuses on the current understanding of molecular mechanisms by which podocyte intercellular junction proteins such as the nephrin-neph1-podocin-receptor complex coordinate cytoskeletal dynamics and thus intercellular junction formation, maintenance, and injury-dependent remodeling.
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm.
Cambridge, United Kingdom. In Nature, 2009
We find that fly (Drosophila melanogaster) orthologues of the major constituents of the slit diaphragm, including nephrin, NEPH1 (also known as KIRREL), CD2AP, ZO-1 (TJP1) and podocin, are expressed in the nephrocyte and form a complex of interacting proteins that closely mirrors the vertebrate slit diaphragm complex.