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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Kin of IRRE like

Neph1, nephronectin, KIRREL, NPNT
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008] (from NCBI)
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Top mentioned proteins: Nephrin, CAN, HAD, V1a, NPHS2
Papers on Neph1
Cell Adhesion Molecules and Stem Cell-Niche-Interactions in the Limbal Stem Cell Niche.
Schlötzer-Schrehardt et al., Erlangen, Germany. In Stem Cells, Jan 2016
Moreover, junctional adhesion molecule JAM-C accumulating in the subepithelial limbal matrix, appeared to be involved in recruitment of immune cells, while mesenchymal stromal cells appeared to use the nephronectin receptor integrin α8 for approaching the limbal basement membrane.
Shp2 associates with and enhances nephrin tyrosine phosphorylation and is necessary for foot process spreading in mouse models of podocyte injury.
Garg et al., Ann Arbor, United States. In Mol Cell Biol, Jan 2016
The cell adhesion proteins nephrin and neph1 localize to the slit diaphragm and transduce signals in a Src Family kinase Fyn mediated tyrosine phosphorylation-dependent manner.
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.
Hall et al., Vancouver, Canada. In Lancet Respir Med, Oct 2015
We discovered six novel genome-wide significant signals of association with extremes of FEV1, including signals at four novel loci (KANSL1, TSEN54, TET2, and RBM19/TBX5) and independent signals at two previously reported loci (NPNT and HLA-DQB1/HLA-DQA2).
Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.
Hellman et al., Uppsala, Sweden. In Endocr Relat Cancer, Oct 2015
We observed significant transcription upregulation of CYP11B2, as well as the previously described glomerulosa-specific gene NPNT, in ATP1A1/ATP2B3 mutated tumors compared to KCNJ5 mutated tumors.
Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing.
Mertens et al., Lund, Sweden. In Lab Invest, Sep 2015
To assess the gene fusion status of FH further, deep sequencing of RNA (RNA-Seq) was performed on FFPE tissue from eight cases with unknown gene fusion status, as well as on two FH and six soft tissue sarcomas with known gene fusions; of the latter eight positive controls, the expected fusion transcript was found in all but one, while 2/8 FH with unknown genetic status showed fusion transcripts, including a novel KIRREL/PRKCA chimera.
Deletion of the App-Runx1 region in mice models human partial monosomy 21.
Herault et al., Illkirch-Graffenstaden, France. In Dis Model Mech, Jun 2015
Further studies confirmed a gene dosage effect in the Ms5Yah hippocampus, and pinpointed disruptions of pathways related to cell adhesion (involving App, Cntnap5b, Lgals3bp, Mag, Mcam, Npnt, Pcdhb2, Pcdhb3, Pcdhb4, Pcdhb6, Pcdhb7, Pcdhb8, Pcdhb16 and Vwf).
Vascularisation for cardiac tissue engineering: the extracellular matrix.
Engel et al., Erlangen, Germany. In Thromb Haemost, Mar 2015
We discuss the potential of extracellular matrix molecules in promoting vascularisation and introduce nephronectin as an example of a new promising candidate.
Novel biomarkers indicating repair or progression after acute kidney injury.
Kellum et al., Pittsburgh, United States. In Curr Opin Nephrol Hypertens, 2015
Specifically, the role of novel biomarkers including neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and nephronectin (NPNT) in the recovery process has been studied, but it has not reached the point of widespread clinical implementation.
Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules.
Kawachi et al., Niigata, Japan. In World J Nephrol, 2014
After then, CD2 associated protein, NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit diaphragm.
miRNAs regulate expression and function of extracellular matrix molecules.
Yang et al., Toronto, Canada. In Matrix Biol, 2013
Proteins such as collagen, fibronectin, versican, and nephronectin are targeted by several miRNAs.
Signaling from the podocyte intercellular junction to the actin cytoskeleton.
Holzman et al., Philadelphia, United States. In Semin Nephrol, 2012
This review focuses on the current understanding of molecular mechanisms by which podocyte intercellular junction proteins such as the nephrin-neph1-podocin-receptor complex coordinate cytoskeletal dynamics and thus intercellular junction formation, maintenance, and injury-dependent remodeling.
Solution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS).
Nihalani et al., Chandīgarh, India. In J Biol Chem, 2012
Neph1-CD adopts a global shape in solution, and its interaction with ZO-1 involves multiple sites.
Comparative analysis of Neph gene expression in mouse and chicken development.
Kispert et al., Köln, Germany. In Histochem Cell Biol, 2012
Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken.
A non-coding transcript of nephronectin promotes osteoblast differentiation by modulating microRNA functions.
Yang et al., Toronto, Canada. In Febs Lett, 2011
expression of a fragment containing the 3'-untranslated region (3'-UTR) of nephronectin in osteoblast progenitor cells MC3T3-E1 promoted cell differentiation
Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α.
Kamijo et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
These results suggest that TNF-alpha inhibits POEM expression through the NF-kappaB signaling pathway and down-regulation of POEM influences the inhibition of osteoblast differentiation by TNF-alpha.
Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.
Nihalani et al., Philadelphia, United States. In Mol Cell Biol, 2011
Localization of Neph1 to the podocyte cell membrane is altered in the presence of mutant Myo1c, and is actin dependent. Knockdown of Myo1c inhibits Neph1 membrane localization. Neph1 is critical for the maintenance of glomerular function.
The basement membrane of hair follicle stem cells is a muscle cell niche.
Watt et al., Cambridge, United Kingdom. In Cell, 2011
We show that stem cells in the bulge deposit nephronectin into the underlying basement membrane, thus regulating the adhesion of mesenchymal cells expressing the nephronectin receptor, α8β1 integrin, to the bulge.
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm.
Denholm et al., Cambridge, United Kingdom. In Nature, 2009
We find that fly (Drosophila melanogaster) orthologues of the major constituents of the slit diaphragm, including nephrin, NEPH1 (also known as KIRREL), CD2AP, ZO-1 (TJP1) and podocin, are expressed in the nephrocyte and form a complex of interacting proteins that closely mirrors the vertebrate slit diaphragm complex.
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates.
Roy et al., Singapore, Singapore. In Nat Genet, 2007
Here we provide evidence that Kirrel, a homolog of receptor proteins that organize myoblast fusion in Drosophila melanogaster, is necessary for muscle precursor fusion in zebrafish.
The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans.
Bargmann et al., San Francisco, United States. In Cell, 2003
SYG-1 is related to Drosophila IrreC and vertebrate NEPH1 proteins, which mediate cell-cell recognition in diverse developmental contexts.
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