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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NEL-like 1

Nell-1, Nel-like
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, Runx2, HAD, osteopontin
Papers using Nell-1 antibodies
The osteoinductive properties of Nell-1 in a rat spinal fusion model
Supplier
Soo Chia et al., In Journal of Bone and Mineral Research, 2006
... Nell-1 transgenic mice ...
Papers on Nell-1
Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2.
New
Soo et al., Los Angeles, United States. In Am J Pathol, Feb 2016
The differentiation factor NEL-like molecule-1 (NELL-1) has been reported as osteoinductive in multiple in vivo preclinical models.
Nel-like Molecule 1 Contributes to the Odontoblastic Differentiation of Human Dental Pulp Cells.
New
Wang et al., Jinan, China. In J Endod, Jan 2016
INTRODUCTION: Nel-like molecule-1 (Nell-1) with epidermal cell growth factor-like coding structures is a recently discovered secreted protein that can specifically induce osteoblast differentiation, bone formation, and bone regeneration.
Accelerated Chondrogenic Differentiation of Human Perivascular Stem Cells with NELL-1.
New
Zhou et al., Beijing, China. In Tissue Eng Part A, Jan 2016
A putative pro-chondrogenic growth factor, NEL-like molecule-1 (NELL-1), was added to the hPSC pellets to upregulate gene expression of chondrogenic markers including AGGRECAN, COLLAGEN II, and COMP.
Mapping the heparin-binding site of the osteoinductive protein NELL1 by site-directed mutagenesis.
New
Niimi et al., Nagoya, Japan. In Febs Lett, Jan 2016
Neural epidermal growth factor-like (NEL)-like 1 (NELL1) is a secretory osteogenic protein comprising an N-terminal thrombospondin-1-like (TSPN) domain, four von Willebrand factor type C domains, and six epidermal growth factor-like repeats.
Genetics of emotional reactivity in bipolar disorders.
New
Bellivier et al., Paris, France. In J Affect Disord, Jan 2016
In the 11p15.1 region, the rs10766743 located in the intron of the NELL1 gene remained significant after correction for multiple testing (p=2×10(-7)).
Brief Report: Human Perivascular Stem Cells and Nel-Like Protein-1 Synergistically Enhance Spinal Fusion in Osteoporotic Rats.
New
Soo et al., South Korea. In Stem Cells, Oct 2015
The purpose of this study is to determine the efficacy of human perivascular stem cells (hPSCs), a population of mesenchymal stem cells isolated from adipose tissue, in the presence and absence of NELL-1, an osteogenic protein, for spinal fusion in the osteoporosis.
Pharmacokinetics and osteogenic potential of PEGylated NELL-1 in vivo after systemic administration.
New
Soo et al., Los Angeles, United States. In Biomaterials, Jul 2015
NELL-1, a secretory protein that promotes osteogenesis while suppressing osteoclastic activity, holds potential as an osteoporosis therapy.
Biologic adjuvants and bone: current use in orthopedic surgery.
New
Ekstein et al., North Bay Shore, United States. In Curr Rev Musculoskelet Med, Jun 2015
Many others, including mesenchymal stem cells, parathyroid hormone, and Nel-like molecule-1 (NELL-1) will likely be in use in the future depending on the results of preclinical and clinical trials.
NELL-1 expression in benign and malignant bone tumors.
New
James et al., Los Angeles, United States. In Biochem Biophys Res Commun, Jun 2015
NELL-1 (NEL-like Protein 1) is an osteoinductive protein with increasing usage as a bone graft substitute in preclinical animal models.
Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma.
New
Ooi et al., Kanazawa, Japan. In Cancer Sci, May 2015
Although the osteogenic effects of NELL1 and functions of NELL2 in neural development have been reported, their expression and functions in cancer are largely unknown.
NELL-1 in the treatment of osteoporotic bone loss.
Soo et al., Los Angeles, United States. In Nat Commun, 2014
NELL-1 is a secreted, osteoinductive protein whose expression rheostatically controls skeletal ossification.
Discovery of microarray-identified genes associated with ovarian cancer progression.
Yin et al., Nanning, China. In Int J Oncol, 2014
Six genes, including aldehyde dehydrogenase 1 family, member A2 (ALDH1A2), alcohol dehydrogenase 1B (class I), β polypeptide (ADH1B), NEL-like 2 (chicken) (NELL2), hemoglobin, β (HBB), ATP-binding cassette, sub-family A (ABC1), member 8 (ABCA8) and hemoglobin, α1 (HBA1) were identified to be downregulated by at least 10-fold in 779 ovarian cancers compared with 18 normal controls.
Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease.
Review
Okajima et al., Nagoya, Japan. In World J Biol Chem, 2014
In mammals, extracellular O-GlcNAc was detected on extracellular proteins including heparan sulfate proteoglycan 2, Nell1, laminin subunit alpha-5, Pamr1, and transmembrane proteins, including Notch receptors.
Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation.
Review
James, Los Angeles, United States. In Scientifica (cairo), 2012
These include β -catenin dependent Wnt signaling, Hedgehog signaling, and NELL-1 signaling.
Genetic polymorphisms inside and outside the MHC improve prediction of AS radiographic severity in addition to clinical variables.
GeneRIF
Mulero et al., Spain. In Rheumatology (oxford), 2012
Prediction of radiographic severity in Ankolysing Spondylitis based on clinical variables can be significantly improved by including SNPs at ADRB1 (rs1801253), NELL1 (rs8176785) and MHC (rs1634747, rs9270986, rs7451962 and rs241453) genes.
The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin α3β1.
GeneRIF
Niimi et al., Nagoya, Japan. In Febs Lett, 2012
The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1
NELL-1 increases pre-osteoblast mineralization using both phosphate transporter Pit1 and Pit2.
GeneRIF
Soo et al., Los Angeles, United States. In Biochem Biophys Res Commun, 2012
These results identify one potential mechanism of action for rhNELL-1 induced osteogenesis and highlight a fundamental difference between NELL-1 and BMP-2 signaling.
Calvarial cleidocraniodysplasia-like defects with ENU-induced Nell-1 deficiency.
GeneRIF
Soo et al., Los Angeles, United States. In J Craniofac Surg, 2012
data suggest Nell-1 is important growth factor for regulation of osteochondral differentiation regulating both Runx2 and Sox9 expression in calvarium. Nell-1 is required for normal craniofacial membranous and endochondral skeletal development.
NELL-1, an osteoinductive factor, is a direct transcriptional target of Osterix.
GeneRIF
Soo et al., Los Angeles, United States. In Plos One, 2010
Results suggest that Osterix is a direct transcriptional regulator with repressive effect on NELL-1 gene expression, contributing to a delicate balance of regulatory effects on NELL-1 transcription with Runx2.
The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration.
Review
GeneRIF
Soo et al., Los Angeles, United States. In J Dent Res, 2010
a potent growth factor that is highly specific to the osteochondral lineage, and has demonstrated robust induction of bone in multiple in vivo models [review]
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