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NIMA

Nek1, NIMA-related kinase
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, Inactive, CDC2
Papers on Nek1
Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer.
New
Zogopoulos et al., Rochester, United States. In Cancer Lett, Feb 2016
Additional genetic evidence for causality was obtained for 17 genes, with FAN1, NEK1 and RHNO1 emerging as the strongest candidates.
A NIMA-related kinase CNK4 regulates ciliary stability and length.
New
Pan et al., Beijing, China. In Mol Biol Cell, Feb 2016
UNASSIGNED: NIMA-related kinases (Nrks or Neks) have emerged as key regulators of ciliogenesis.
FOXM1 is a therapeutic target for high-risk multiple myeloma.
New
Janz et al., Nanjing, China. In Leukemia, Jan 2016
Expression of cyclin dependent kinase 6 (CDK6) and NIMA-related kinase 2 (NEK2) was co-regulated with FOXM1 in both HMCLs and myeloma patient samples, suggesting interaction of these 3 genes in a genetic network that may lend itself to targeting with small-drug inhibitors for new approaches to myeloma therapy and prevention.
The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.
New
Zhang et al., Houston, United States. In Acta Biochim Biophys Sin (shanghai), Oct 2015
C21ORF2 (chromosome 21 open reading frame 2) is a novel gene on chromosome 21, and the C21ORF2 protein is found to interact with NEK1.
A NIMA-Related Kinase Suppresses the Flagellar Instability Associated with the Loss of Multiple Axonemal Structures.
New
Dutcher et al., Saint Louis, United States. In Plos Genet, Sep 2015
Enrichment screens for suppression of pf7; pf8 cells led to the isolation of five independent extragenic suppressors defined by four different mutations in a NIMA-related kinase, CNK11.
Anks3 alters the sub-cellular localization of the Nek7 kinase.
New
Yakulov et al., Freiburg, Germany. In Biochem Biophys Res Commun, Sep 2015
Here, we show that Anks3, but not Anks6 interacted with the NIMA-related kinase Nek7, and was heavily modified in the presence of Nek7, resulting in an approximately 20 kD increase in molecular weight.
Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer.
Zhong et al., Guangzhou, China. In Bmc Urol, 2014
BACKGROUND: The NIMA-related kinase 2 (NEK2) is a serine/threonine kinase that is involved in regulation of centrosome duplication and spindle assembly during mitosis.
Array CGH Analysis of Paired Blood and Tumor Samples from Patients with Sporadic Wilms Tumor.
Martínez-Glez et al., Rio de Janeiro, Brazil. In Plos One, 2014
Candidate genes included in these regions might be constitutively (SIX3, SALL4) or somatically (NEK1, PIAS4, BMP2) operational in the development and progression of WT.
The structural mechanisms that underpin mitotic kinase activation.
Review
Bayliss et al., Oxford, United Kingdom. In Biochem Soc Trans, 2013
These include members of the Cdk (cyclin-dependent kinase), Plk (Polo-like kinase), Aurora, Nek (NimA-related kinase) and Bub families, as well as Haspin, Greatwall and Mps1/TTK.
Cell cycle regulation by the NEK family of protein kinases.
Review
Bayliss et al., Leicester, United Kingdom. In J Cell Sci, 2012
Since that discovery, NIMA-related kinases, or NEKs, have been identified in most eukaryotes, including humans where eleven genetically distinct proteins named NEK1 to NEK11 are expressed.
Ciliary disorder of the skeleton.
Review
Cormier-Daire et al., Paris, France. In Am J Med Genet C Semin Med Genet, 2012
Mutations have been identified in dynein motor (DYNC2H1), in intraflagellar transport (IFT) complexes (IFT80, IFT122, IFT43, WDR35, WDR19, and TTC21B) as well as in genes responsible for the basal body (NEK1, EVC, and EVC2).
NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases.
GeneRIF
Cormier-Daire et al., Paris, France. In J Med Genet, 2012
This study confirms that NEK1 is one gene causing SRP type II but also reports mutations in DYNC2H1, expanding the phenotypic spectrum of DYNC2H1 mutations.
Short rib-polydactyly syndrome type II (Majewski): prenatal diagnosis, perinatal imaging findings and molecular analysis of the NEK1 gene.
GeneRIF
Wang et al., Taipei, Taiwan. In Taiwan J Obstet Gynecol, 2012
The present case provides evidence for a correlation of NEK1 mutation with short rib-polydactyly syndrome type II (Majewski.
Nek1 and TAZ interact to maintain normal levels of polycystin 2.
GeneRIF
Benjamin et al., Boston, United States. In J Am Soc Nephrol, 2011
data suggest that TAZ and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ maintain polycystin 2 at the level needed for proper ciliogenesis
Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry.
Impact
Kutay et al., Zürich, Switzerland. In Cell, 2011
Using chemical inhibition and depletion experiments we show that NPC disassembly is a phosphorylation-driven process, dependent on CDK1 activity and supported by members of the NIMA-related kinase (Nek) family.
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
GeneRIF
Chen et al., Irvine, United States. In Cell Cycle, 2011
results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR
Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability.
GeneRIF
Riley et al., Irvine, United States. In Mol Cancer, 2010
NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability
The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners.
Review
Hengstschläger et al., Vienna, Austria. In Mutat Res, 2008
Tuberin interacts with 14-3-3 beta,epsilon,gamma,eta,sigma,tau,zeta, Akt, AMPK, CaM, CRB3/PATJ, cyclin A, cyclins D1, D2, D3, Dsh, ERalpha, Erk, FoxO1, HERC1, HPV16 E6, HSCP-70, HSP70-1, MK2, NEK1, p27KIP1, Pam, PC1, PP2Ac, Rabaptin-5, Rheb, RxRalpha/VDR and SMAD2/3.
Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C.
Impact
Fry et al., Leicester, United Kingdom. In Nat Cell Biol, 2006
In particular, it is unclear why the mitotic checkpoint prevents the anaphase-promoting complex/cyclosome (APC/C)-mediated degradation of cyclin B and securin in early mitosis, but not cyclin A. Here, we show that another APC/C substrate, NIMA-related kinase 2A (Nek2A), is also destroyed in pro-metaphase in a checkpoint-independent manner and that this depends on an exposed carboxy-terminal methionine-arginine (MR) dipeptide tail.
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
Review
Liu et al., San Antonio, United States. In Am J Physiol Endocrinol Metab, 2005
So far, at least 10 kinases have been suggested to function as an HM kinase or the so-called "PDK2," including mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2), integrin-linked kinase (ILK), p38 MAP kinase, protein kinase Calpha (PKCalpha), PKCbeta, the NIMA-related kinase-6 (NEK6), the mammalian target of rapamycin (mTOR), the double-stranded DNA-dependent protein kinase (DNK-PK), and the ataxia telangiectasia mutated (ATM) gene product.
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