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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nei endonuclease VIII-like 2

NEIL2, Neh2
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: NEIL1, OGG1, Nrf2, NEI, Keap1
Papers on NEIL2
Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.
Niehrs et al., Mainz, Germany. In Nat Struct Mol Biol, Feb 2016
Here we show that human NEIL1 and NEIL2 DNA glycosylases coordinate abasic-site processing during TET-TDG DNA demethylation.
Genetic Variation of BCL2 (rs2279115), NEIL2 (rs804270), LTA (rs909253), PSCA (rs2294008) and PLCE1 (rs3765524, rs10509670) Genes and Their Correlation to Gastric Cancer Risk Based on Universal Tagged Arrays and Fe3O4 Magnetic Nanoparticles.
Cui et al., In J Biomed Nanotechnol, Nov 2015
With the help of Fe3O4 nagnetic nanoparticles as a solid carrier and an excellent tool for separation, six SNP loci (rs2279115 of BCL2 gene, rs804270 of NEIL2 gene, rs909253 of LTA gene, rs2294008 of PSCA gene, rs3765524 and rs10509670 of PLCE1 gene) were selected to evaluate their relation to gastric cancer risk.
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Hazra et al., Berkeley, United States. In J Biol Chem, Nov 2015
Here, we report the generation and characterization of mice lacking Neil2 (Nei-like 2).
A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?
Burrows et al., Salt Lake City, United States. In Acs Cent Sci, Sep 2015
These new "spare tire"-containing strands with Gh in loops are now found to be substrates for initiation of BER with the NEIL1, NEIL2, and NEIL3 DNA glycosylases.
[Characteristic of the Genetic Variability of Four Polymorphic Variants (rs2069705, rs17880053, rs11126176, and rs804271) in Representative Samples of Indigenous and Alien Populations of Siberia].
Puzyrev et al., In Genetika, Aug 2015
The variability of potentially important functional polymorphic variants rs2069705 (5'UTR of the IFNG gene), rs17880053 (near 5'UTR of the IFNGR2), rs11126176 (LOC100287361 pseudogene), and rs804271 (near 5'UTR of the NEIL2 gene) was characterized in representatives of four ethnic groups living in the Siberian region.
Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).
He et al., In J Nanosci Nanotechnol, Jul 2015
To investigate the independent roles of single nucleotide polymorphisms (SNPs) in base excision repair (BER) genes (APE1 and NEIL2), carcinogen metabolism gene (CYP2E1) and tumor suppressor pathway gene (MDM2) for gastric cancer susceptibility in a Chinese population, we conducted a hospital based case-control study to evaluate the potential association between these polymorphisms and susceptibility to gastric cancer in a Northern Jiangsu population.
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures.
Wallace et al., Burlington, United States. In Nucleic Acids Res, May 2015
However, NEIL1, NEIL2 and NEIL3 remove hydantoins from telomeric quadruplexes formed by five TTAGGG repeats much more rapidly than the commonly studied four-repeat quadruplex structures.
Accelerating the Conformational Sampling of Intrinsically Disordered Proteins.
Karttunen et al., Waterloo, Canada. In J Chem Theory Comput, 2014
The total simulation time was over 10 μs, and a 20-mer peptide derived from the Neh2 domain of the Nuclear factor erythroid 2-related factor 2 (Nrf2) protein was simulated.
Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway.
Boldogh et al., Galveston, United States. In J Immunol, 2014
Mice deficient in OGG1-BER showed significantly decreased immune responses, whereas a lack of other Nei-like DNA glycosylases (i.e., NEIL1 and NEIL2) had no significant effect.
DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers.
Benitez et al., Madrid, Spain. In Plos Genet, 2014
The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16),
Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage.
Wallace et al., Burlington, United States. In Mutat Res, 2013
Endonuclease VIII like proteins (Neil1, Neil2 and Neil3) are found in vertebrate genomes and are homologous to the well-characterized bacterial DNA glycosylases, Formamidopyrimidine DNA glycosylase (Fpg) and Endonuclease VIII (Nei).
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2.
Hazra et al., Galveston, United States. In Dna Repair (amst), 2012
Results suggest that the decreased DNA repair capacity of the DNA glycosylase NEIL2 R257L variant can induce mutations that lead to lung cancer development.
Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.
Hazra et al., Galveston, United States. In J Biol Chem, 2012
the critical role of NEIL2 and PNKP in maintenance of the mammalian mitochondrial genome.
REG4, NEIL2, and BIRC5 gene expression correlates with gamma-radiation sensitivity in patients with rectal cancer receiving radiotherapy.
Fukusato et al., Tokyo, Japan. In Anticancer Res, 2011
REG4, BIRC5 and NEIL2 genes might have a role in the sensitivity of cancer patients to radiotherapy
Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity.
Khan et al., Galveston, United States. In Toxicol Appl Pharmacol, 2011
In the spleen aniline-induced oxidative stress is associated with an induction of NEIL1/2.
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
Yamamoto et al., Sendai, Japan. In Genes Cells, 2011
Biochemical and structural analyses have revealed that the intact Keap1 homodimer forms a cherry-bob structure in which one molecule of Nrf2 associates with two molecules of Keap1 by using two binding sites within the Neh2 domain of Nrf2.
Eukaryotic endonuclease VIII-like proteins: new components of the base excision DNA repair system.
Zharkov et al., Novosibirsk, Russia. In Biochemistry (mosc), 2011
In 2002, three new human DNA glycosylases (NEIL1, NEIL2, and NEIL3) were discovered, all homologous to endonuclease VIII, a bacterial protein, which also participates in DNA repair.
Discovery of the negative regulator of Nrf2, Keap1: a historical overview.
Yamamoto et al., Hirosaki, Japan. In Antioxid Redox Signal, 2011
Keap1 suppresses Nrf2 activity by specifically binding to its evolutionarily conserved N-terminal Neh2 regulatory domain.
Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding.
Zharkov et al., Novosibirsk, Russia. In Biochem Biophys Res Commun, 2010
the beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity.
Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors.
Weinfeld et al., Edmonton, Canada. In Anticancer Agents Med Chem, 2008
Strand breaks that are caused by many agents including ionizing radiation, topoisomerase I inhibitors, and DNA repair glycosylases such as NEIL1 and NEIL2, often contain 5'-hydroxyl and/or 3'-phosphate termini.
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