Mutations of c-Cbl in myeloid malignancies.
Jerusalem, Israel. In Oncotarget, Jun 2015
The c-Cbl protein displays several enzymatic functions by promoting the attachment of differentially composed ubiquitin chains and of the ubiquitin-like protein NEDD8 to its target proteins.
Protein neddylation: beyond cullin-RING ligases.
Zürich, Switzerland. In Nat Rev Mol Cell Biol, 2015
NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin-RING ligases.
Selecting key genes associated with osteosarcoma based on a differential expression network.
Jinan, China. In Genet Mol Res, 2014
Pathway-enrichment analysis indicated that the nodes in the differential expression network were mainly enriched in several pathways such as those involved in cancer, cell cycle, ubiquitin-mediated proteolysis, DNA replication, ribosomes, T-cell receptor signaling, spliceosomes, neurotrophin signaling, oxidative phosphorylation, and tight junctions.
Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data.
In Bmc Syst Biol, 2014
Genes, including UBC, CUL3, APP, NEDD8, JUP, and SIRT7, showed high associations with time after a stroke, and Ingenuity Pathway Analysis results showed that these post-stroke time series-associated genes were related to molecular and cellular functions of cell death, cell survival, the cell cycle, cellular development, cellular movement, and cell-to-cell signaling and interactions.