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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neural precursor cell expressed, developmentally down-regulated 8

NEDD8, Rub1
Encodes a ubiquitin-related protein that is conjugated to target proteins by neddylation. It has been shown to be conjugated to the cullin AtCUL1. The RUB-conjugation pathway has been implicated in in auxin response. (from NCBI)
Top mentioned proteins: Ubiquitin, Cullin, CAN, V1a, SCF
Papers using NEDD8 antibodies
Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal tight junction barrier
MacLeod R. John et al., In Frontiers in Physiology, 2005
... TNFR1, TNFR2, Cullin-1, and Nedd8 antibodies were obtained from Cell Signaling Technology (Boston, MA, USA) ...
Papers on NEDD8
Pevonedistat, a NEDD8 activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo.
Hernandez-Ilizaliturri et al., Buffalo, United States. In Blood, Jan 2016
UNASSIGNED: Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and inevitable development of refractory disease stressing the need to develop alternative therapeutic strategies.
Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination.
Das et al., West Lafayette, United States. In Proc Natl Acad Sci U S A, Jan 2016
This type of molecular recognition appears to enable dual specificity toward ubiquitin and the ubiquitin-like modifier NEDD8.
A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction.
Sun et al., Atlanta, United States. In Sci Rep, Dec 2015
Results suggested that 2 SNPs located on chromosomes 14 (NEDD8; rs11158609; raw p = 9.80 × 10(-9), genomic control-adjusted p = 2.09 × 10(-7)) and 17 (TTYH2; rs8078051; raw p = 6.28 × 10(-8), genomic control-adjusted p = 9.65 × 10(-7)) were associated with SBP including the genetic interaction with cigarette smoking.
Mutations of c-Cbl in myeloid malignancies.
Schmitz et al., Jerusalem, Israel. In Oncotarget, Jun 2015
The c-Cbl protein displays several enzymatic functions by promoting the attachment of differentially composed ubiquitin chains and of the ubiquitin-like protein NEDD8 to its target proteins.
Ubiquitylation, neddylation and the DNA damage response.
Jackson et al., Cambridge, United Kingdom. In Open Biol, Apr 2015
Ubiquitin and the ubiquitin-like protein (UBL) SUMO have established roles in regulating the cellular response to DNA double-strand breaks (DSBs).
Protein neddylation: beyond cullin-RING ligases.
Peter et al., Zürich, Switzerland. In Nat Rev Mol Cell Biol, 2015
NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin-RING ligases.
Group 9 organometallic compounds for therapeutic and bioanalytical applications.
Leung et al., Hong Kong, Hong Kong. In Acc Chem Res, 2015
Research in our laboratory has shown that cyclometalated octahedral rhodium(III) complexes were active against Janus kinase 2 (JAK2) or NEDD8-activating enzyme (NAE) activity, or against NO production leading to antivasculogenic activity in cellulo.
The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair.
Dellaire et al., Halifax, Canada. In Biomolecules, 2014
Post-translational modifications by ubiquitin and ubiquitin-like proteins, such as SUMO and NEDD8, have roles in coordinating the progression of DDR.
High-Pressure NMR Spectroscopy Reveals Functional Sub-states of Ubiquitin and Ubiquitin-Like Proteins.
Kitahara, Kusatsu, Japan. In Subcell Biochem, 2014
The high-energy states are conserved among ubiquitin-like post-translational modifiers, ubiquitin, NEDD8, and SUMO-2, showing the E1-E2-E3 cascade reaction.
How Cryptococcus interacts with the blood-brain barrier.
Jong et al., Taipei, Taiwan. In Future Microbiol, 2014
Several Cryptococcal genes related to the traversal of BBB have been identified, including CPS1, ITR1a, ITR3c, PLB1, MPR1, FNX1 and RUB1.
Selecting key genes associated with osteosarcoma based on a differential expression network.
Jia et al., Jinan, China. In Genet Mol Res, 2014
Pathway-enrichment analysis indicated that the nodes in the differential expression network were mainly enriched in several pathways such as those involved in cancer, cell cycle, ubiquitin-mediated proteolysis, DNA replication, ribosomes, T-cell receptor signaling, spliceosomes, neurotrophin signaling, oxidative phosphorylation, and tight junctions.
Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data.
Chen et al., In Bmc Syst Biol, 2014
Genes, including UBC, CUL3, APP, NEDD8, JUP, and SIRT7, showed high associations with time after a stroke, and Ingenuity Pathway Analysis results showed that these post-stroke time series-associated genes were related to molecular and cellular functions of cell death, cell survival, the cell cycle, cellular development, cellular movement, and cell-to-cell signaling and interactions.
Crystal structure of the human COP9 signalosome.
Thomä et al., Basel, Switzerland. In Nature, 2014
Cullin-RING E3 ubiquitin ligases (CRLs) are regulated by the eight-subunit COP9 signalosome (CSN).
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.
Schulman et al., Memphis, United States. In Cell, 2014
We report the structure of a trapped RING E3-E2∼UBL-target intermediate representing RBX1-UBC12∼NEDD8-CUL1-DCN1, which reveals the mechanism of NEDD8 ligation and how a particular UBL and acceptor lysine are matched by a multifunctional RING E3.
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
Deshaies et al., Pasadena, United States. In J Biol Chem, 2012
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif.
Banfield et al., Norwich, United Kingdom. In Proc Natl Acad Sci U S A, 2012
We report the crystal structures of two Cif/NEDD8 complexes, revealing a conserved molecular interface that defines enzyme/substrate recognition.
X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7.
Kamada et al., Kōbe, Japan. In Febs Lett, 2012
XIAP does not function as a NEDD8-E3 ligase for caspase-7 in vivo
Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease.
Wakabayashi et al., Hirosaki, Japan. In Pathol Int, 2012
In the present study, the proportions of intranuclear inclusion positive for NEDD8, NUB1 and SUMO-1 were significantly lower in glial cells than in neurons.
Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.
Smith et al., Cambridge, United States. In Cancer Cell, 2012
MLN4924 is an investigational small-molecule inhibitor of NEDD8-activating enzyme (NAE) in clinical trials for the treatment of cancer.
Inhibition of the NEDD8 conjugation pathway by shRNA to UBA3, the subunit of the NEDD8-activating enzyme, suppresses the growth of melanoma cells.
Sun et al., Nanjing, China. In Asian Pac J Cancer Prev, 2011
High NEDD8 is associated with melanoma.
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