NEDD4-2 and salt-sensitive hypertension.
Lausanne, Switzerland. In Curr Opin Nephrol Hypertens, Mar 2015
SUMMARY: The emerging role of NEDD4-2 in the regulation of different Na+ transporters along the nephron and the identification of human polymorphisms in the NEDD4-2 gene (Nedd4L) related to salt-sensitive hypertension makes this ubiquitin-protein ligase an interesting target for the development of antihypertensive drugs.
NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins.
Adelaide, Australia. In Gene, Mar 2015
NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover.
NEDD4-1 and PTEN expression in keloid scarring.
Hefei, China. In Genet Mol Res, 2014
The aim of this study was to determine the expression of the PTEN tumor suppressor and NEDD4-1 genes in keloid tissue and explore their effect on the formation of such scarring.
WWP2 is an E3 ubiquitin ligase for PTEN.
Hyderābād, India. In Nat Cell Biol, 2011
WWP2 is an E3 ubiquitin ligase that belongs to the NEDD4-like protein family, which is involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes.