GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Neural precursor cell expressed, developmentally down-regulated 1
NEDD1, GCP-WD
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Papers using
NEDD1
antibodies
NEDD1-dependent recruitment of the γ-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly
Supplier
In The Journal of Cell Biology, 2003
... NEDD1 was then subcloned into pEGFPC2 (CLONTECH Laboratories, Inc.) using the ...
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Supplier
In The Journal of Cell Biology, 2000
... The following antibodies were obtained from commercial sources: monoclonal anti-NEDD1 (Abnova Corporation); anti-GFP clone 3E6 ...
Papers on
NEDD1
Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice.
New
Tokyo, Japan. In Cancer Sci, 28 Feb 2013
The mice treated with small interfering (si) RNA targeting NEDD1, which encodes a gamma-tubulin ring complex-binding protein, by the atelocollagen-mediated delivery system showed a significantly prolonged survival.
The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.
New
Barcelona, Spain. In Curr Biol, 21 Feb 2013
Here we show that Aurora A interacts with and phosphorylates the γTURC adaptor protein NEDD1 at a single residue, Ser405.
CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly.
New
Toronto, Canada. In Cell Cycle, Nov 2012
We previously reported that CEP192 interacts with NEDD1, a protein that associates with the γ-tubulin ring complex (γ-TuRC) and regulates its phosphorylation status during mitosis.
Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity.
New
Beijing, China. In Cell Res, Sep 2012
Its interaction with NEDD1 is necessary for the centrosome localization of Cep57.
Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.
New
Barcelona, Spain. In Curr Biol, Sep 2012
Centrosomal γ-tubulin recruitment depends on the adaptor protein NEDD1/GCP-WD and is controlled by the kinase Plk1.
Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly.
New
Toronto, Canada. In J Cell Sci, Sep 2012
NEDD1 is a γ-TuRC-interacting protein whose depletion, although not affecting γ-TuRC stability, causes spindle defects similar to the inhibition of its core subunits, including γ-tubulin.
Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex.
New
Ikoma, Japan. In Plant J, Jul 2012
Functional fusions of GIP1a with green fluorescent protein (GFP) were used to purify GIP1a-containing complexes from Arabidopsis plants, which contained all the subunits (except NEDD1) previously identified in the Arabidopsis γ-tubulin complexes.
Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRC.
New
Oxford, United Kingdom. In Biol Open, Jun 2012
Dgp71WD/Nedd1 proteins are essential for mitotic spindle formation.
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.
Seoul, South Korea. In J Cell Biol, 2012
Phosphoresistant point mutants of PCNT did not recruit centrosomal proteins, such as CEP192, GCP-WD (γ-complex protein with WD repeats), γ-tubulin, Aurora A, and PLK1, into the centrosome during mitosis.
Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1.
Bethesda, United States. In Proc Natl Acad Sci U S A, 2011
Mechanistically, we demonstrated that Cdc2-dependent phosphorylation on a γ-tubulin ring complex (γ-TuRC) recruitment protein, Nedd1/GCP-WD, at the previously uncharacterized S460 residue induces the Nedd1-Plk1 interaction.
A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage.
Galway, Ireland. In Mol Biol Cell, 2010
Using live-cell imaging of cells that express fluorescently tagged NEDD1/GCP-WD and proliferating cell nuclear antigen, we found that ionizing radiation (IR)-induced centrosome amplification can occur outside S phase.
The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8.
Barcelona, Spain. In Mol Biol Cell, 2010
In Drosophila, Xenopus, and humans large γ-tubulin ring complexes (γTuRCs) have been described, which have a characteristic open ring-shaped structure and are composed of a similar set of subunits, named γ-tubulin, GCPs 2-6, and GCP-WD in humans.
NEDD1 is crucial for meiotic spindle stability and accurate chromosome segregation in mammalian oocytes.
GeneRIF
United States. In Dev Biol, 2010
NEDD1 is an essential component of acentriolar oocyte MTOCs, which functions in the regulation of meiotic spindle stability
A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.
GeneRIF
Adelaide, Australia. In Plos One, 2009
a direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome
A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts.
GeneRIF
Adelaide, Australia. In Cell Death Dis, 2009
Disrupting the centrosome in early-passage mouse embryonic fibroblasts by depletion of NEDD1 also resulted in centrosomal fragmentation and subsequent premature entry into senescence.
Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.
GeneRIF
Beijing, China. In J Cell Sci, 2009
Data suggest that sequential phosphorylation of Nedd1 by Cdk1 and Plk1 plays a role in targeting gamma tubulin ring complex to the centrosome by promoting the interaction of Nedd1 with the gammaTuRC component gamma-tubulin, during mitosis.
The WD40 repeat protein NEDD1 functions in microtubule organization during cell division in Arabidopsis thaliana.
GeneRIF
Davis, United States. In Plant Cell, 2009
NEDD1 homolog plays a critical role in MT organization during mitosis.
NEDD1: function in microtubule nucleation, spindle assembly and beyond.
Review
Adelaide, Australia. In Int J Biochem Cell Biol, 2006
Nedd1 was originally identified as a developmentally regulated gene in the mouse central nervous system.
GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.
Impact
GeneRIF
Stanford, United States. In Nat Cell Biol, 2006
GCP-WD (NEDD1) broadly mediates targeting of the gamma-tubulin ring complex to sites of microtubule nucleation and to the mitotic spindle, which is essential for spindle formation.
