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Poliovirus receptor-related 3

nectin-3, PRR3, APRR3
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: nectin-1, Actin, CLOCK, poliovirus receptor, CAB
Papers using nectin-3 antibodies
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
Supplier
Miyoshi Jun et al., In Journal of Cell Science, 1998
... All of the following antibodies were purchased from commercial sources: antibodies against afadin and nectin-3 (ABcam), nectin-1 (Santa Cruz Biotechnology), ...
Papers on nectin-3
Regulatory role of the cell adhesion molecule nectin-1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus.
New
Mori et al., Kōbe, Japan. In Genes Cells, Jan 2016
We previously showed that cell adhesion molecules nectin-1 and nectin-3 are localized at puncta adherentia junctions of the hippocampal mossy fiber glutamatergic excitatory synapses and that they do not regulate the excitatory synaptic transmission onto the CA3 pyramidal cells.
A new method for detection of tumor driver-dependent changes of protein sialylation in a colon cancer cell line reveals nectin-3 as TGFBR2 target.
New
Kopitz et al., Heidelberg, Germany. In Protein Sci, Oct 2015
Validation of detected candidate glycoproteins is demonstrated with the cell surface glycoprotein nectin-3 known to be involved in metastasis, invasion and prognosis of various cancers.
Core clock, SUB1, and ABAR genes mediate flooding and drought responses via alternative splicing in soybean.
New
Nguyen et al., Columbia, United States. In J Exp Bot, Sep 2015
PRR3 exhibited flooding- and drought-specific splicing patterns and may work in concert with PRR7 and TOC1 to achieve energy homeostasis under flooding and drought conditions.
Quantitative Circadian Phosphoproteomic Analysis of Arabidopsis Reveals Extensive Clock Control of Key Components in Physiological, Metabolic, and Signaling Pathways.
New
Somers et al., South Korea. In Mol Cell Proteomics, Aug 2015
Our approach was sensitive enough to quantitate oscillations in the phosphorylation of low abundance clock proteins (early flowering4; ELF4 and pseudoresponse regulator3; PRR3) as well as other transcription factors and kinases.
Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.
New
Yu et al., Beijing, China. In Mol Reprod Dev, Jun 2015
Mechanistically, the Spata31 deficiency resulted in reduced expression of the adhesion protein nectin-3 and cytoskeletal protein β-actin at the apical ectoplasmic specialization.
Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis.
New
Nakagohri et al., Japan. In Surg Today, Apr 2015
The cases that showed diffuse nectin-3 expression had a better prognosis than those with negative expression (p = 0.018).
Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site.
New
Hiroaki et al., Kōbe, Japan. In Protein Sci, Mar 2015
Here, we report the first crystal structure of the AFPDZ in complex with the nectin-3 C-terminal peptide containing the class II motif.
Quantitative analysis of the cellular composition in seminiferous tubules in normal and genetically modified infertile mice.
New
Iseki et al., Kōbe, Japan. In J Histochem Cytochem, Feb 2015
We then examined seminiferous tubules from genetically modified mice deficient (-/-) for one of the cell adhesion molecules, nectin-2 or nectin-3, and compared the number of each cell type at each stage of spermatogenesis with the corresponding value in normal mice.
Focal adhesion kinase is involved in rabies virus infection through its interaction with viral phosphoprotein P.
New
Blondel et al., Gif-sur-Yvette, France. In J Virol, Feb 2015
The binding involved the 106-to-131 domain, corresponding to the dimerization domain of P and the C-terminal domain of FAK containing the proline-rich domains PRR2 and PRR3.
s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin.
Takai et al., Kōbe, Japan. In Genes Cells, 2014
The PDZ domain of l-afadin and s-afadin was essential for their binding to nectin-3.
Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent manner.
Tsai et al., Taiwan. In Ophthalmology, 2014
RESULTS: Strong gender effects on the distribution of the SNPs were apparent: male GD patients carrying an A allele at rs2074503 in the PRR3 gene tended to avoid demonstrating GO (P = 0.008; OR, 0.450; 95% CI, 0.248-0.819),
Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations.
Sandi et al., Lausanne, Switzerland. In Nat Commun, 2013
Emerging evidence suggests a role for cell adhesion molecules, including nectin-3, in the mechanisms that underlie the behavioural effects of stress.
Characterization of nectin processing mediated by presenilin-dependent γ-secretase.
GeneRIF
Lim et al., Washington, D.C., United States. In J Neurochem, 2011
Nectin-3, which forms hetero-trans-dimers with nectin-1, undergoes intramembrane cleavage mediated by PS1/gamma-secretase.
Nectins establish a checkerboard-like cellular pattern in the auditory epithelium.
Impact
GeneRIF
Takai et al., Kōbe, Japan. In Science, 2011
hair cells and supporting cells express nectin-1 and -3, respectively; their interaction mediates the heterotypic adhesion between these 2 cell types; nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia
Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth.
GeneRIF
Thesleff et al., Helsinki, Finland. In Dev Dyn, 2010
Results suggest that heterophilic interaction between nectin-1 and nectin-3 recruits desmosomal junctions, and that these are required for proper enamel formation.
Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
GeneRIF
Mostov et al., San Francisco, United States. In Am J Physiol Renal Physiol, 2009
expressed in early epithelial structures of the nephron generated from metanephric mesenchyme
Roles of cell adhesion molecules nectin and nectin-like molecule-5 in the regulation of cell movement and proliferation.
Review
Takai et al., Suita, Japan. In J Microsc, 2008
Necl-5 first interacts in trans with nectin-3.
Post-translational regulation of the Arabidopsis circadian clock through selective proteolysis and phosphorylation of pseudo-response regulator proteins.
GeneRIF
Somers et al., Columbus, United States. In J Biol Chem, 2008
TOC1/PRR3 phosphorylation-dependent interaction may protect TOC1 from ZTL-mediated degradation, resulting in an enhanced amplitude of TOC1 cycling
The acrosome-acroplaxome-manchette complex and the shaping of the spermatid head.
Review
Tres et al., New York City, United States. In Arch Histol Cytol, 2004
The tubulobulbar complex might provide stabilizing conditions, together with the actin-afadin-nectin-2/nectin-3 adhesion unit, to enable sustained and balanced clutching exogenous forces applied during the elongation of the spermatid head.
Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization.
Review
Ikeda et al., Suita, Japan. In Cancer Sci, 2003
One of them, named necl-5, which does not homophilically trans-interact, but heterophilically trans-interacts with nectin-3, regulates cell migration and adhesion.
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