Structure-function relationships in mammalian histidine-proline-rich glycoprotein.
Pisa, Italy. In Biochimie, Nov 2015
The multidomain arrangement of HPRG comprises two modules at the N-terminus that are homologous to cystatin but void of cysteine proteinase inhibitor function, and a second half consisting of a histidine-proline-rich region (HPRR) located between two proline-rich regions (PRR1 and PRR2), and a C-terminus domain.
Innate immunity in atopic dermatitis.
München, Germany. In Clin Rev Allergy Immunol, 2011
Eczema herpeticum is a disseminated viral infection almost exclusively diagnosed in AD patients, which is based on unmasking of the viral entry receptor nectin-1, lack of cathelicidin production by keratinocytes, and depletion of Type I IFN-producing plasmacytoid dendritic cells from AD skin.