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Ndst1, NST1, hsst1, glucosaminyl N-deacetylase/N-sulfotransferase, N-deacetylase/N-sulfotransferase-1
enzyme that catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to the nitrogen of glucosamine in heparan sulfate [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, NAC, HAD, ACID, somatostatin
Papers on Ndst1
Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines.
Grigorieva et al., Novosibirsk, Russia. In Oncotarget, Jan 2016
In this study, expression of major proteoglycans (syndecan-1, glypican-1, perlecan, versican, brevican, aggrecan, NG2, serglycin, decorin, biglycan, lumican, CD44), heparan sulphate (HS) metabolic system (EXT1/2, NDST1/2, GLCE, HS2ST1, HS3ST1/2, HS6ST1/2, SULF1/2, HPSE) and extracellular matrix (ECM) components (collagen 1A1, fibronectin, elastin) in primary B cells and EBV carrying cell lines with different phenotypes, patterns of EBV-host cell interaction and viral latency stages (type I-III) was investigated.
TBL3 and TBL31, Two Arabidopsis DUF231 Domain Proteins, are Required for 3-O-Monoacetylation of Xylan.
Ye et al., Athens, United States. In Plant Cell Physiol, Dec 2015
The expression of both TBL3 and TBL31 was shown to be induced by overexpression of the secondary wall master transcriptional regulator SND1 (secondary wall-associated NAC domain protein1) and down-regulated by simultaneous mutations of SND1 and its paralog NST1, indicating their involvement in secondary wall biosynthesis.
Tissue-specificity of heparan sulfate biosynthetic machinery in cancer.
Grigorieva et al., Novosibirsk, Russia. In Cell Adh Migr, Dec 2015
To reveal cancer-related changes in transcriptional pattern of HS biosynthetic system, the expression of HS metabolism-involved genes (EXT1/2, NDST1/2, GLCE, 3OST1/HS3ST1, SULF1/2, HPSE) in human normal (fibroblasts, PNT2) and cancer (MCF7, LNCaP, PC3, DU145, H157, H647, A549, U2020, U87, HT116, KRC/Y) cell lines and breast, prostate, colon tumors was studied.
Role of Deacetylase Activity of N-Deacetylase/N-Sulfotransferase 1 in Forming N-Sulfated Domain in Heparan Sulfate.
Liu et al., Chapel Hill, United States. In J Biol Chem, Sep 2015
N-Deacetylase/N-Sulfotransferase isoform 1 (NDST-1) is a critical enzyme in this pathway.
Combining enhanced biomass density with reduced lignin level for improved forage quality.
Dixon et al., Denton, United States. In Plant Biotechnol J, Aug 2015
Plants with low-level expression of the WRKY dominant repressor construct produced lignified cell walls in pith tissues and exhibited enhanced biomass and biomass density, with an increase in total sugars in the cell wall fraction; however, lines with high expression of the WRKY dominant repressor construct exhibited a very different phenotype, with loss of interfascicular fibres associated with repression of the NST1 transcription factor.
Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.
Kao et al., Cincinnati, United States. In Invest Ophthalmol Vis Sci, May 2015
METHODS: An inducible quadruple transgenic mouse model was generated to excise Ext1 and Ndst1, which encode the critical HS chain elongation enzyme and N-deacetylase/N-sulfotransferase, respectively, in keratin 14-positive cells upon doxycycline induction.
Reconstitution of a secondary cell wall in a secondary cell wall-deficient Arabidopsis mutant.
Mitsuda et al., Tsukuba, Japan. In Plant Cell Physiol, Feb 2015
In this proof-of-concept study, we expressed chimeric activators of 24 transcription factors that are preferentially expressed in the stem, in empty fiber cells of the Arabidopsis nst1-1 nst3-1 double mutant, which lacks a secondary cell wall in fiber cells, under the control of the NST3 promoter.
Functional Characterization of NAC and MYB Transcription Factors Involved in Regulation of Biomass Production in Switchgrass (Panicum virgatum).
Ye et al., Athens, United States. In Plos One, 2014
Transactivation and complementation studies demonstrated that PvSWNs were able to activate the SNBE-driven GUS reporter gene and effectively rescue the secondary wall defects in the Arabidopsis snd1 nst1 double mutant, indicating that they are functional orthologs of Arabidopsis SWNs.
The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation.
Kjellén et al., Uppsala, Sweden. In Plos One, 2014
The glucosaminyl N-deacetylase/N-sulfotransferase (NDST) enzymes catalyze N-deacetylation and N-sulfation during HS biosynthesis and have a key role in designing the sulfation pattern.
The Arabidopsis NAC transcription factor NST2 functions together with SND1 and NST1 to regulate secondary wall biosynthesis in fibers of inflorescence stems.
Ye et al., United States. In Plant Signal Behav, 2014
Transcriptional regulation of secondary wall biosynthesis in Arabidopsis thaliana has been shown to be mediated by a group of secondary wall NAC master switches, including NST1, NST2, SND1 and VND1 to VND7.
Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling.
Esko et al., San Diego, United States. In Cell Metab, 2014
To examine their role in atherogenesis, we inactivated the biosynthetic gene N-acetylglucosamine N-deacetylase-N-sulfotransferase 1 (Ndst1) in macrophages and crossbred the strain to Ldlr(-/-) mice.
A comprehensive transcriptome analysis of silique development and dehiscence in Arabidopsis and Brassica integrating genotypic, interspecies and developmental comparisons.
Cutler et al., Canada. In Gm Crops Food, 2013
Among known Arabidopsis dehiscence genes, we confirmed that homologs of SHP1/2, FUL, ADPG1, NST1/3 and IND were associated with shattering in B. juncea and B. napus.
Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious mice.
Adhikari et al., Minneapolis, United States. In J Cardiovasc Transl Res, 2012
Deletion of N-deacetylase-N-sulfotransferase1 in smooth muscle did not influence any of the blood pressure parameters measured despite significant decrease in aorta and thoracodorsal artery luminal area.
Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells.
Forsberg-Nilsson et al., Uppsala, Sweden. In J Biol Chem, 2012
embryonic stem cells lacking both NDST1 and NDST2, expressing a very low sulfated heparan sulfate, can take the initial step toward differentiation into all three germ layers
Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.
Abrink et al., Uppsala, Sweden. In J Biol Chem, 2012
Lowered expression of NDST1 also results in a higher sulfate content of the heparin synthesized and is accompanied by increased levels of stored MC proteases.
MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803.
Chen et al., Jingzhou, China. In Acta Biochim Biophys Sin (shanghai), 2011
MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803
The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfate.
Liu et al., Chapel Hill, United States. In J Biol Chem, 2011
the regulating role of NDST-1 in mapping the sulfation patterns of HS.
Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1.
Kjellén et al., Uppsala, Sweden. In Prog Mol Biol Transl Sci, 2009
In this review, basic features of the Ndst1 enzyme are covered and a brief description of HS biosynthesis and its regulation is presented.
Glucosaminyl N-deacetylase/N-sulphotransferases in heparan sulphate biosynthesis and biology.
Kjellén, Uppsala, Sweden. In Biochem Soc Trans, 2003
In addition, we study mice in which the gene encoding NDST-1 or NDST-2 has been knocked out.
Binding properties of somatostatin receptor subtypes.
Weckbecker et al., Basel, Switzerland. In Metabolism, 1996
A single Ser305 to Phe mutation in TM VII increased the affinity of hsst1, for SMS 201-995 nearly 100-fold, and when Gln291 was also exchanged to Asn in TM VII of hsst1, almost full sst2-like binding of SMS 201-995 was obtained.
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