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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NDRG family member 4

NDRG4, Bdm1, SMAP8, smooth muscle-associated protein 8
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: c-Myc, N-myc, KRAS, BMP-3, HAD
Papers on NDRG4
N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway.
New
Zhang et al., Xi'an, China. In Basic Res Cardiol, Mar 2016
N-myc downstream-regulated gene 4 (NDRG4) is expressed weakly in heart and has been reported to modulate cardiac development and QT interval duration, but the role of NDRG4 in myocardial ischemia/reperfusion (I/R) injury remains unknown.
Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.
New
Peter et al., New York City, United States. In Pharmacogenomics J, Dec 2015
Variants within or near TAS1R3, LCA5, DNAH5, PTPRG, MAGI1, PTCSC3, STRADA, AKAP12, ARFGEF2, ADCYAP1, SETX, NDRG4 and ABCB11 modified glucose response, and near CSF1/AHCYL1 potassium response (P2df⩽4.26
NDRG4 stratifies the prognostic value of body mass index in colorectal cancer.
New
Chu et al., Xi'an, China. In Oncotarget, Nov 2015
UNASSIGNED: NDRG4 is a novel candidate tumor suppressor and can inhibit PI3K/AKT signal which is related with energy balance and related carcinogenesis.
New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice.
New
Ahlquist et al., Rochester, United States. In Clin Cancer Res, Nov 2015
Pancreatic juice AUC values for CD1D, KCNK12, CLEC11A, NDRG4, IKZF1, PKRCB, and KRAS were 0.92*, 0.88, 0.85, 0.85, 0.84, 0.83, and 0.75, respectively, for pancreatic cancer compared with normal pancreas and 0.92*, 0.73, 0.76, 0.85*, 0.73, 0.77, and 0.62 for pancreatic cancer compared with chronic pancreatitis (*, P = 0.001 vs. KRAS).
Stool DNA methylation assays in colorectal cancer screening.
New
Nossikoff et al., Sofia, Bulgaria. In World J Gastroenterol, Oct 2015
In this paper, we describe the recent advances in non-invasive CRC screening and more specifically in molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions.
NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells.
New
Jaboin et al., Saint Louis, United States. In Oncotarget, Aug 2015
We have recently identified NDRG4 overexpression in aggressive meningiomas.
Adipose tissue gene expression and metabolic health of obese adults.
New
Sharma et al., Winston-Salem, United States. In Int J Obes (lond), May 2015
We identified significant upregulation of 141 genes (for example, MMP9 and SPP1) and downregulation of 17 genes (for example, NDRG4 and GINS3) in group 2 subjects.
NDRG4, a novel candidate tumor suppressor, is a predictor of overall survival of colorectal cancer patients.
New
Zheng et al., Xi'an, China. In Oncotarget, May 2015
The role of NDRG4 in human malignancies is largely unknown.
[Fecal Biomarker for Colorectal Cancer Diagnosis].
Review
New
Matsumura et al., In Rinsho Byori, Mar 2015
DNA mutation of APC, KRAS, and TP53 genes and DNA methylation of VIM, TFPI2, BMP3, NDRG4, and SFRP2 genes were reported as fecal DNA biomarkers.
Quantitative detection of methylated NDRG4 gene as a candidate biomarker for diagnosis of colorectal cancer.
New
Ye et al., Beijing, China. In Oncol Lett, Mar 2015
UNASSIGNED: The present study explored the use of methylated NDRG4 gene as a candidate biomarker for diagnosis of colorectal cancer (CRC).
Spectrin repeat containing nuclear envelope 1 and forkhead box protein E1 are promising markers for the detection of colorectal cancer in blood.
New
van Engeland et al., Maastricht, Netherlands. In Cancer Prev Res (phila), Feb 2015
Previously, we identified N-Myc downstream-regulated gene 4 (NDRG4) and GATA binding protein 5 (GATA5) methylation as promising biomarkers for colorectal cancer in stool DNA.
Multitarget stool DNA testing for colorectal-cancer screening.
Impact
Berger et al., Framingham, United States. In N Engl J Med, 2014
The DNA test includes quantitative molecular assays for KRAS mutations, aberrant NDRG4 and BMP3 methylation, and β-actin, plus a hemoglobin immunoassay.
NDRG4 is downregulated in glioblastoma and inhibits cell proliferation.
GeneRIF
Lin et al., Hangzhou, China. In Omics, 2012
Over expression of NDRG4 inhibited proliferation of GBM cells.
NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.
GeneRIF
Miyata et al., Suita, Japan. In J Biol Chem, 2011
NDRG4 contributes to the maintenance of intracerebral BDNF levels within the normal range
NDRG4 is required for cell cycle progression and survival in glioblastoma cells.
GeneRIF
Datto et al., Durham, United States. In J Biol Chem, 2009
NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells
N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer.
GeneRIF
van Engeland et al., Maastricht, Netherlands. In J Natl Cancer Inst, 2009
NDRG4 is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation.
Identification and action of N-myc downstream regulated gene 4 A2 in rat pancreas.
GeneRIF
Hill et al., London, Canada. In J Endocrinol, 2009
NDRG4A2 is expressed in pancreatic duct cells under GLP-1 control and may be related to a reduction in proliferation and the onset of the pancreas cell differentiation.
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Impact
Chakravarti et al., München, Germany. In Nat Genet, 2009
Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within NDRG4-GINS3-SETD6-CNOT1, respectively, all of which have not previously been implicated in cardiac electrophysiology.
Common variants at ten loci influence QT interval duration in the QTGEN Study.
Impact
Stricker et al., Boston, United States. In Nat Genet, 2009
Associations were found at five newly identified loci, including 16q21 near NDRG4 and GINS3, 6q22 near PLN, 1p36 near RNF207, 16p13 near LITAF and 17q12 near LIG3 and RFFL.
NDRG2: a Myc-repressed gene involved in cancer and cell stress.
Review
Liu et al., Xi'an, China. In Acta Biochim Biophys Sin (shanghai), 2008
The N-myc downstream-regulated gene (NDRG) family is composed of NDRG1, NDRG2, NDRG3 and NDRG4, which are important in cell proliferation and differentiation.
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