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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NDRG family member 2

NDRG2, NDR2, N-myc downstream-regulated gene 2, Nodal-related
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: c-Myc, N-myc, NODAL, CAN, V1a
Papers on NDRG2
NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
New
Gao et al., Hefei, China. In Biochem Biophys Res Commun, Feb 2016
A diversity of miRNAs is involved in neuronal development, survival, function, and plasticity, but the exact functional role of NDRG2 and secreted miR-375 in MVs in neuron damage is poorly understood.
NDRG2 Expression Decreases Tumor-Induced Osteoclast Differentiation by Down-regulating ICAM1 in Breast Cancer Cells.
New
Lim et al., Seoul, South Korea. In Biomol Ther (seoul), Jan 2016
The N-myc downstream-regulated gene 2 (NDRG2) has been known to contribute to the suppression of tumor growth and metastasis, but the precise role of NDRG2 in osteoclast differentiation induced by cancer cells has not been elucidated.
Low expression of N-myc downstream-regulated gene 2 (NDRG2) correlates with poor prognosis in hepatoblastoma.
New
Kappler et al., München, Germany. In Hepatol Int, Jan 2016
METHODS: In the present study, expression and promoter methylation of the N-myc downstream-regulated gene (NDRG2), a tumor suppressor gene contributing to the regulation of the Wnt signalling pathway, was analysed in 38 hepatoblastoma samples by real-time reverse transcription-PCR and pyrosequencing, respectively.
Expression and prognostic value of the aldehyde dehydrogenase 1 (ALDH1) and N-myc downstream regulated gene 2 (NDRG2) as potential markers in human astrocytomas.
New
Abdolhoseinpour et al., Tehrān, Iran. In Tumour Biol, Dec 2015
UNASSIGNED: In this study, immunohistochemical analysis was used to evaluate the expression of ALDH1 and NDRG2 in astrocytoma tissue samples and normal brain tissues.
Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer.
Review
New
Yang et al., Xi'an, China. In Oncotarget, Nov 2015
UNASSIGNED: N-myc downstream-regulated gene 2 (NDRG2) is a tumor suppressor and cell stress-related gene.
N-myc downstream-regulated gene 2 in the nervous system: from expression pattern to function.
Review
New
Li et al., Xi'an, China. In Acta Biochim Biophys Sin (shanghai), Oct 2015
Human N-myc downstream-regulated gene 2 (NDRG2) has been shown to be a multifunctional protein associated with cell proliferation, differentiation, transmembrane transport, and stress responses.
N-myc downstream regulated gene 2 overexpression reduces matrix metalloproteinase-2 and -9 activities and cell invasion of A549 lung cancer cell line in vitro.
New
Takhshid et al., Shīrāz, Iran. In Iran J Basic Med Sci, Aug 2015
OBJECTIVES: N-myc downstream regulated gene 2 (NDRG2) is a candidate gene for tumor suppression.
Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?
Review
New
Micke et al., Uppsala, Sweden. In Expert Rev Mol Diagn, Apr 2015
Only 26 proteins first described after 2008 (ALDH1A1, ANXA1, BCAR1, CLDN1, EIF4E, EZH2, FOLR1, FOXM1, IL7R, IL12RB2, KIAA1524, CRMP1, LOX, MCM7, MTA1, MTDH, NCOA3, NDRG2, NEDD9, NES, PBK, PPM1D, SIRT1, SLC7A5, SQSTM1 and WNT1) demonstrated a consistent prognostic association in two or more independent patient cohorts, thus qualifying as promising candidates for diagnostic use.
The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway.
Review
Han et al., Jinan, China. In Am J Cardiovasc Drugs, 2014
Insulin can protect cardiomyocytes from apoptosis by regulating a number of signaling molecules, such as eNOS, FOXOs, Bad, GSK-3β, mTOR, NDRG2, and Nrf2, through activating PI3K and Akt.
Nodal signalling determines biradial asymmetry in Hydra.
Impact
Holstein et al., Heidelberg, Germany. In Nature, 2014
We identified a Nodal-related gene (Ndr) in Hydra magnipapillata, and this gene is essential for setting up an axial asymmetry along the main body axis.
Ndrg2 regulates vertebral specification in differentiating somites.
GeneRIF
Guo et al., Shanghai, China. In Dev Biol, 2012
Loss of Ndrg2 resulted in vertebral homeotic transformations in thoracic/lumbar and lumbar/sacral transitional regions in a dose-dependent manner.
Protein kinases of the Hippo pathway: regulation and substrates.
Review
Barrufet et al., Boston, United States. In Semin Cell Dev Biol, 2012
In mammals, the Hippo orthologs Mst1 and Mst2 utilize the Salvador ortholog WW45/Sav1 and other scaffolds to regulate the kinases Lats1/Lats2 and ndr1/ndr2.
Microarray profiling of HepG2 cells ectopically expressing NDRG2.
GeneRIF
Yao et al., Xi'an, China. In Gene, 2012
this research provides the molecular basis for understanding the role of NDRG2 in tumor cells and raises interesting questions about its mechanisms and potential use in cancer therapy.
Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.
Impact
GeneRIF
Schier et al., Cambridge, United States. In Science, 2012
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway.
GeneRIF
Zon et al., Boston, United States. In Dev Cell, 2012
This study identified a Nanog-like-Mxtx2-Nodal pathway and establishes a role for Nanog-like in regulating the formation of the extraembryonic tissue required for endoderm induction.
Inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cells.
GeneRIF
Zhang et al., Xi'an, China. In Plos One, 2011
analysis of inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cells
The zebrafish dorsal axis is apparent at the four-cell stage.
Impact
Sampath et al., Singapore, Singapore. In Nature, 2006
Here we show that maternal transcripts of the zebrafish Nodal-related morphogen, Squint (Sqt), can localize to two blastomeres at the four-cell stage and predict the dorsal axis.
The zebrafish Nodal signal Squint functions as a morphogen.
Impact
Schier et al., New York City, United States. In Nature, 2001
Here we test the morphogen properties of Cyclops and Squint-two Nodal-related transforming growth factor-beta signals required for mesoderm formation and patterning in zebrafish.
Arkadia enhances nodal-related signalling to induce mesendoderm.
Impact
Jones et al., London, United Kingdom. In Nature, 2001
The combined activities of Arkadia and Xenopus nodal-related-1 are sufficient to induce mesendoderm and suppress mesoderm.
Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.
Impact
Casey et al., Bethesda, United States. In Nat Genet, 2000
EGF-CFC proteins act as co-factors for Nodal-related signals, which have also been implicated in L-R axis development.
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