gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

N-myc downstream regulated 1

NDRG1, RTP, Cap43, Drg1, NDR1
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: c-Myc, N-myc, NDR, CAN, ACID
Papers using NDRG1 antibodies
Functional properties of rab15 effector protein in endocytic recycling.
Supplier
Heisenberg Carl-Philipp, In PLoS ONE, 2004
... For cloning NDRG1 full length gene in a mammalian expression vector NDRG1 was amplified from a prostate cDNA library (Clontech) using reverse primers that ...
Papers on NDRG1
Identification of ovarian cancer subtype-specific network modules and candidate drivers through an integrative genomics approach.
New
Xia et al., Hefei, China. In Oncotarget, Jan 2016
Our analysis revealed that alterations in DLST module involved in metabolism pathway and NDRG1 module were common between the two subtypes.
Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.
New
Ono et al., Fukuoka, Japan. In Sci Rep, Dec 2015
N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D).
A Follow-Up of the Multicenter Collaborative Study on HIV-1 Drug Resistance and Tropism Testing Using 454 Ultra Deep Pyrosequencing.
New
454 HIV-1 Alpha Study Group et al., Branford, United States. In Plos One, Dec 2015
METHODS: A multicenter study was conducted to validate an updated assay design for 454 Life Sciences' GS FLX Titanium system targeting protease/reverse transcriptase (RTP) and env (V3) regions to identify HIV-1 drug-resistance mutations and determine co-receptor use with high sensitivity.
Rutin-Mediated Priming of Plant Resistance to Three Bacterial Pathogens Initiating the Early SA Signal Pathway.
New
Chu et al., China. In Plos One, Dec 2015
We also demonstrated that the rutin-mediated priming resistance was attenuated in npr1, eds1, eds5, pad4-1, ndr1 mutants, and NahG transgenic Arabidopsis plant, while not in either snc1-11, ein2-5 or jar1 mutants.
The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets.
Review
New
Richardson et al., Shanghai, China. In Oncotarget, Dec 2015
Particular emphasis is bestowed on the potent metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1) and its interactions with the Src signaling cascade.
Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43.
New
Kim et al., Seoul, South Korea. In Acta Pharm Sin B, Nov 2015
Fucoidan was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPK-dependent NDRG-1/CAP43 and partly, under normoxic conditions, through up-regulation of p42/44 MAPK-dependent VMP-1 expression.
Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition.
Review
Richardson et al., Sydney, Australia. In Biochim Biophys Acta, 2014
The general mechanisms by which iron chelators selectively target tumour cells through the sequestration of intracellular iron fall into the following categories: (1) inhibition of cellular iron uptake/promotion of iron mobilisation; (2) inhibition of ribonucleotide reductase, the rate-limiting, iron-containing enzyme for DNA synthesis; (3) induction of cell cycle arrest; (4) promotion of localised and cytotoxic reactive oxygen species production by copper and iron complexes of thiosemicarbazones (e.g., Triapine(®) and Dp44mT); and (5) induction of metastasis and tumour suppressors (e.g., NDRG1 and p53, respectively).
Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.
Review
Richardson et al., Sydney, Australia. In Biochim Biophys Acta, 2014
N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple cancers, being also involved in embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses and immunity.
[Emerging roles of phospholipase A2s in mast cell biology].
Review
Taketomi, Tokyo, Japan. In Yakugaku Zasshi, 2013
In addition, the roles of two particular mast cell maturation-responsible genes, NDRG1 and NLRP3, in mast cells will be discussed.
Favipiravir (T-705), a novel viral RNA polymerase inhibitor.
Review
Barnard et al., Toyama, Japan. In Antiviral Res, 2013
It is phosphoribosylated by cellular enzymes to its active form, favipiravir-ribofuranosyl-5'-triphosphate (RTP).
Mammostrat as an immunohistochemical multigene assay for prediction of early relapse risk in the tamoxifen versus exemestane adjuvant multicenter trial pathology study.
Impact
Rea et al., Toronto, Canada. In J Clin Oncol, 2013
Triplicate 0.6-mm(2) TMA cores were stained, and positivity for p53, HTF9C, CEACAM5, NDRG1, and SLC7A5 was assessed.
Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Impact
Taylor et al., Toronto, Canada. In Nature, 2012
Recurrent translocations of PVT1, including PVT1-MYC and PVT1-NDRG1, that arise through chromothripsis are restricted to Group 3. Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy.
The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).
GeneRIF
Richardson et al., Shanghai, China. In J Biol Chem, 2012
chelators inhibit the TGF-beta-induced EMT via a process consistent with NDRG1 up-regulation and elucidates the mechanism of their activity.
NDRG1/Cap43/Drg-1 may predict tumor angiogenesis and poor outcome in patients with lung cancer.
GeneRIF
Kuwano et al., Kurume, Japan. In J Thorac Oncol, 2012
Loss of NDRG1 is associated with tumor angiogenesis in lung cancer.
Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron.
GeneRIF
Thomas et al., Chicago, United States. In J Biol Chem, 2012
a link between (*)NO, chelatable iron, and regulation of NDRG1 expression and signaling in tumor cells.
The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1.
GeneRIF
Fares et al., Haifa, Israel. In J Biomed Biotechnol, 2011
Results suggest that N-myc downstream regulated gene-1 expression is enhanced by 3,3'-diindolylmethane in poorly differentiated cells and followed by induction of apoptosis.
Down-regulation of NDRG1 promotes migration of cancer cells during reoxygenation.
GeneRIF
Chuang et al., Taipei, Taiwan. In Plos One, 2010
Upon reoxygenation, overexpression of NDRG1 significantly inhibited cell migration
Autophagic components contribute to hypersensitive cell death in Arabidopsis.
Impact
Petersen et al., Copenhagen, Denmark. In Cell, 2009
Furthermore, we demonstrate that PCD triggered by coiled-coil (CC)-type immune receptors via NDR1 is either autophagy-independent or engages autophagic components with cathepsins and other unidentified cell death mediators.
Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer.
Impact
Ross et al., Burlingame, United States. In J Clin Oncol, 2006
RESULTS: In both validation cohorts, the Kaplan-Meier estimates of recurrence confirmed that both the Cox model using five reagents (p53, NDRG1, CEACAM5, SLC7A5, and HTF9C) and the regression tree model using six reagents (p53, PR, Ki67, NAT1, SLC7A5, and HTF9C) distinguished estrogen receptor (ER)-positive patients with poor outcomes.
RTP family members induce functional expression of mammalian odorant receptors.
Impact
Matsunami et al., Durham, United States. In Cell, 2004
Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical in order for the receptors to recognize their ligands.
share on facebooktweetadd +1mail to friends