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Nedd4 family interacting protein 1

Ndfip1, N4WBP5, Nedd4 family interacting protein-1, Nedd4-WW domain-binding protein 5
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Nedd4, Ubiquitin, CAN, Itch, PTEN
Papers on Ndfip1
MiR-338-5p sensitizes glioblastoma cells to radiation through regulation of genes involved in DNA damage response.
New
Slaby et al., Brno, Czech Republic. In Tumour Biol, Jan 2016
To better elucidate the mechanism of action, we performed gene expression profiling analysis that revealed targets of miR-338-5p being Ndfip1, Rheb, and ppp2R5a.
Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).
New
Zhang et al., Kingston, Canada. In Biochem J, Dec 2015
In the present study, we demonstrate that Nedd4-2 is directed to specific cellular compartments by the Nedd4 family interacting proteins, Nedd4 family-interacting protein 1 (Ndfip1) and Ndfip2.
Protective effects of Ndfip1 on MPP(+)-induced apoptosis in MES23.5 cells and its underlying mechanisms.
New
Xie et al., Qingdao, China. In Exp Neurol, Nov 2015
Increasing evidence suggests that Ndfip1 is a neuroprotective protein, and Ndfip1-mediated protein ubiquitination might be a possible survival strategy in neuronal injury.
Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells.
New
Zick et al., Israel. In Biochem Biophys Res Commun, Nov 2015
One of the 'hits' was Nedd4 family interacting protein 1 (Ndfip1), an adaptor and activator of Nedd4-family ubiquitin ligases.
Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation.
New
Oliver et al., Philadelphia, United States. In J Biol Chem, Oct 2015
In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.
iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis.
New
Lin et al., Boston, United States. In Genet Epidemiol, Jul 2015
The iGWAS approach identifies six novel susceptibility genes (MANEA, MRPL53, LYCAT, ST8SIA4, NDFIP1, and PTCH1) using the omnibus test with false discovery rate less than 1%, whereas no gene using SNP-only analyses survives with the same cut-off.
PTEN secretion in exosomes.
New
Tan et al., Melbourne, Australia. In Methods, May 2015
While the conditions favouring the secretion of PTEN-long remain unknown, PTEN secretion in exosomes is enhanced by the Ndfip1/Nedd4 ubiquitination system.
Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity.
New
Tan et al., Melbourne, Australia. In J Mol Cell Biol, Apr 2015
Here we report the control of Pten activity and signaling specificity during the cell cycle by Ndfip1 regulation of Pten spatial distribution.
Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.
New
Tan et al., Melbourne, Australia. In J Biol Chem, Apr 2015
Here we demonstrate that Ndfip1-mediated ubiquitination of BRAT1 leads to BRAT1 trafficking into the cell nucleus.
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
New
Venuprasad et al., Dallas, United States. In J Immunol, Apr 2015
In this study, we found that nontypeable Haemophilus influenzae induces the association of Itch with Ndfip1.
Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.
New
Xie et al., Qingdao, China. In Neurobiol Aging, Feb 2015
Nedd4 family-interacting protein 1 (Ndfip1), an adaptor protein for the Nedd4 family of ubiquitin ligases, played an essential role in regulating DMT1 and iron homeostasis in human cortical neurons.
Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis.
Harley et al., Cincinnati, United States. In Front Genet, 2013
In addition, several new PheWAS findings were identified including a cluster of association near the NDFIP1 gene for mental retardation (best SNP rs10057309, p = 4.33 × 10(-7), OR = 1.70, 95%CI = 1.38 - 2.09); association near PLCL1 gene for developmental delays and speech disorder [best SNP rs1595825, p = 1.13 × 10(-8), OR = 0.65(0.57
The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.
GeneRIF
Oliver et al., Philadelphia, United States. In J Immunol, 2012
Ndfip1 acts to prevent Th17 differentiation, much like it does for Th2 differentiation.
TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation.
Impact
GeneRIF
Oliver et al., Philadelphia, United States. In Nat Immunol, 2012
we propose that TGF-beta signaling induces Ndfip1 expression to silence IL-4 production, thus permitting iT(reg) cell differentiation.
Gastrointestinal microbiota do not significantly contribute to T cell activation or GI inflammation in Ndfip1-cKO mice.
GeneRIF
Oliver et al., Philadelphia, United States. In Plos One, 2011
Mice lacking Ndfip1, an adaptor protein for E3 ubiquitin ligases of the Nedd4-family, in T cells (Ndfip1-cKO) develop a disease resembling IBD.
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
Impact
Australian Asthma Genetics Consortium et al., Brisbane, Australia. In Lancet, 2011
Multi-marker association results are consistent with a highly polygenic contribution to asthma risk, including loci with weak effects that might be shared with other immune-related diseases, such as NDFIP1, HLA-B, LPP, and BACH2.
The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility.
GeneRIF
Oliver et al., Philadelphia, United States. In Mucosal Immunol, 2011
regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility
Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes.
GeneRIF
Tan et al., Melbourne, Australia. In J Biol Chem, 2011
Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes.
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.
Impact
Yang et al., Denver, United States. In Immunity, 2006
Nedd4 family interacting protein-1 (Ndfip1) is a protein whose only known function is that it binds Nedd4, a HECT-type E3 ubiquitin ligase.
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