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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ND6 NADH dehydrogenase, subunit 6 (complex I)

ND6, NADH dehydrogenase subunit 6
Top mentioned proteins: ND4, ND5, DiI, CAN, HAD
Papers on ND6
Complete mitochondrial genome of the gyrfalcon Falco rusticolus (Aves, Falconiformes, Falconidae).
New
Magnússon et al., Akureyri, Iceland. In Mitochondrial Dna, Feb 2016
All genes were encoded on the + strand except ND6 and 8 tRNA genes.
Complete mitochondrial genome of Tlacuatzin canescens (Grayish Mouse Opossum).
New
Pang, Qingdao, China. In Mitochondrial Dna, Jan 2016
Except for ND6 gene, all other PCGs were located on the H-strand.
The near complete mitochondrial genome of white-lipped Treefrog, Polypedates braueri (Anura, Rhacophoridae).
New
Zhang et al., Chengdu, China. In Mitochondrial Dna, Jan 2016
Most of the genes are encoded on the H-strand, except for seven tRNA and ND6, which are encoded on the L-strand.
Graphical Representation and Similarity Analysis of Protein Sequences Based on Fractal Interpolation.
New
Zhou et al., In Ieee/acm Trans Comput Biol Bioinform, Jan 2016
To confirm the validity of our method, eight species in NADH dehydrogenase 6 (ND6) protein families and twenty-seven species in beta-globin protein families were also analyzed.
Mitochondrial genome of Pachytriton feii (Urodela: Salamandridae).
New
Zhang et al., Hefei, China. In Mitochondrial Dna, Jan 2016
All the genes in P. feii were distributed on the H-strand, except for the ND6 subunit gene and eight tRNA genes which were encoded on the L-strand.
The complete mitochondrial genome sequence of Buteo hemilasius (Falconiformes: Accipitridae).
New
Zhang et al., Qufu, China. In Mitochondrial Dna, Jan 2016
A phylogenetic analysis on the basis of 12 protein-coding genes (except ND6 gene) of 14 Falconiformes species' mitochondrial genomes using maximum-likelihood (ML) and Bayesian inference (BI) demonstrated that all species cluster into two clades and B. hemilasius is close to B. buteo.
Medical management of hereditary optic neuropathies.
Review
Carelli et al., Bologna, Italy. In Front Neurol, 2013
The diagnostic workup includes neuro-ophthalmologic evaluation and genetic testing of the three most common mitochondrial DNA mutations affecting complex I (11778/ND4, 3460/ND1, and 14484/ND6) for LHON and sequencing of the nuclear gene OPA1 for DOA.
The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.
Impact
Shoubridge et al., Montréal, Canada. In Cell Metab, 2013
GRSF1 preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long noncoding RNAs for cytb and ND5, each of which contains multiple consensus binding sequences.
Taurine deficiency and MELAS are closely related syndromes.
Review
Azuma et al., Mobile, United States. In Adv Exp Med Biol, 2012
Because 12 out of the 13 mitochondria-encoded proteins are more dependent on UUA decoding than UUG decoding, the aminoacylation defect should have a more profound effect on protein synthesis than the wobble defect, which more specifically alters the expression of one mitochondria-encoded protein, ND6.
Regulation of metastasis; mitochondrial DNA mutations have appeared on stage.
Review
Hayashi et al., Tsukuba, Japan. In J Bioenerg Biomembr, 2012
The results revealed that the G13997A mutation in the ND6 gene of mtDNA from highly metastatic tumor cells reversibly controlled development of metastases by overproduction of reactive oxygen species (ROS).
A novel mtDNA large-scale mutation clinically exclusively presenting with refractory anemia: is there a chance to predict disease progression?
Review
Borkhardt et al., Düsseldorf, Germany. In J Pediatr Hematol Oncol, 2012
Mutation analysis in our patient revealed a large, novel deletion in his mtDNA encompassing ATPase 6, cytochrome oxidase subunit III, NADH dehydrogenase genes ND3 to ND6, and cytochrome b.
Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms.
Review
Papa et al., Bari, Italy. In Adv Exp Med Biol, 2011
Examples of complex I dysfunction are herein presented: homozygous mutations in the nuclear NDUFS1 and NDUFS4 genes for structural components of complex I; an autosomic recessive form of encephalopathy associated with enhanced proteolytic degradation of complex I; familial cases of Parkinson associated to mutations in the PINK1 and Parkin genes, in particular, homoplasmic mutations in the ND5 and ND6 mitochondrial genes of the complex I, coexistent with mutation in the PINK1 gene.
Reduced frequency of known mutations in a cohort of LHON patients from India.
GeneRIF
Fingert et al., Madurai, India. In Ophthalmic Genet, 2010
These results suggest that a different set of LHON-causing mutations is present in the South Indian population than in the European population
Mitochondrial ND6 T14502C variant may modulate the phenotypic expression of LHON-associated G11778A mutation in four Chinese families.
GeneRIF
Guan et al., Wenzhou, China. In Biochem Biophys Res Commun, 2010
These data suggested that the ND6 T14502C variant may modulate the phenotypic manifestation of the G11778A mutation in these Chinese pedigrees.
Progressive myoclonic epilepsy as an adult-onset manifestation of Leigh syndrome due to m.14487T>C.
GeneRIF
Santens et al., Gent, Belgium. In J Neurol Neurosurg Psychiatry, 2010
missense mutation 14487T>C resulted in severe encephalopathies ranging from infantile Leigh syndrome to adult-onset progressive myoclonic epilepsy with dystonia in a five-generation family
Pediatric-onset dystonia associated with bilateral striatal necrosis and G14459A mutation in a Korean family: a case report.
GeneRIF
Park et al., Chinju, South Korea. In J Korean Med Sci, 2010
the G14459A mutation is a candidate mutation for maternally inherited dystonia
Leber's hereditary optic neuropathy is associated with mitochondrial ND6 T14502C mutation.
GeneRIF
Guan et al., Wenzhou, China. In Biochem Biophys Res Commun, 2009
Molecular analysis has led to identification of the known T14502C mutation in ND6 gene in Chinese families with Leber's hereditary optic neuropathy.
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.
Impact
Hayashi et al., Tsukuba, Japan. In Science, 2008
The mtDNA conferring high metastatic potential contained G13997A and 13885insC mutations in the gene encoding NADH (reduced form of nicotinamide adenine dinucleotide) dehydrogenase subunit 6 (ND6).
A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations.
Impact
Wallace et al., Irvine, United States. In Science, 2008
The severe ND6 mutation was selectively eliminated during oogenesis within four generations, whereas the milder COI mutation was retained throughout multiple generations even though the offspring consistently developed mitochondrial myopathy and cardiomyopathy.
Imaging dynamics of endogenous mitochondrial RNA in single living cells.
Impact
Umezawa et al., Tokyo, Japan. In Nat Methods, 2007
We designed the probes to specifically recognize a 16-base sequence of mtRNA encoding NADH dehydrogenase subunit 6 (ND6) and to be targeted into the mitochondrial matrix, which allowed real-time imaging of ND6 mtRNA localization in living cells.
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