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Solute carrier family 8

NCX3, SLC8A3
isoform 3 of the integral membrane sodium/calcium exchanger proteins; maintains intracellular calcium homeostasis [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: HOX11L1, V1a, HAD, CAN, ACID
Papers on NCX3
Calpain-3-mediated regulation of the Na(+)-Ca(2+) exchanger isoform 3.
New
Bindels et al., Nijmegen, Netherlands. In Pflugers Arch, Feb 2016
In neuronal excitotoxicity, the cleavage of the Na(+)-Ca(2+) exchanger isoform 3 (NCX3) has been associated with an increase in activity and elevation of the Ca(2+) content in the endoplasmic reticulum (ER).
Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data.
New
Wijsman et al., Seattle, United States. In Genes Brain Behav, Nov 2015
We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants, and for four genes (SLC8A3, SLC19A3, MADD and LRRK2) with multiple rare-associated variants that have a plausible biological function related to AD.
Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt.
New
Annunziato et al., Napoli, Italy. In J Cereb Blood Flow Metab, Nov 2015
UNASSIGNED: Three different Na(+)/Ca(2+) exchanger (NCX) isoforms, NCX1, NCX2, and NCX3, are expressed in brain where they play a relevant role in maintaining Na(+) and Ca(2+) homeostasis.
Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice.
New
Matsuda et al., Suita, Japan. In Epilepsy Res, Sep 2015
The present study examined the effects of pentylenetetrazole (PTZ)-induced kindling on the mRNA expression of NCX isoforms (NCX1, NCX2 and NCX3) in mouse brain.
Polymorphisms in Ion Transport Genes Are Associated with Eggshell Mechanical Property.
Yang et al., Beijing, China. In Plos One, 2014
Strong linkage disequilibrium (LD) was detected among SNPs in four genes: ATP2A3, ITPR1, SLC8A3, SCNN1a.
Novel Cellular Mechanisms for Neuroprotection in Ischemic Preconditioning: A View from Inside Organelles.
Review
Scorziello et al., Napoli, Italy. In Front Neurol, 2014
In line with these findings and considering that the expression of the three isoforms of the sodium calcium exchanger (NCX), NCX1, NCX2, and NCX3, mainly responsible for the regulation of Ca(2+) homeostasis, was reduced during cerebral ischemia, it was investigated whether these proteins might play a role in neuroprotection induced by ischemic tolerance.
Impact of Na+/Ca2+ Exchangers on Therapy Resistance of Ovary Carcinoma Cells.
Lang et al., In Cell Physiol Biochem, 2014
RESULTS: The transcript levels of NCX3, NCKX4, NCKX5, and NCKX6, slope and peak of x0394;[Ca2+]i as well as Ica were significantly higher in therapy resistant than in therapy sensitive ovary carcinoma cells.
Lead Poisoning Disturbs Oligodendrocytes Differentiation Involved in Decreased Expression of NCX3 Inducing Intracellular Calcium Overload.
Li et al., Chongqing, China. In Int J Mol Sci, 2014
Moreover, Pb treatment inhibits the sodium/calcium exchanger 3 (NCX3) mRNA expression, one of the major means of calcium (Ca(2+)) extrusion at the plasma membrane during OPCs differentiation.
Na (+) /Ca (2+) Exchanger 3 is Downregulated in the Hippocampus and Cerebrocortex of Rats with Hyperthermia-induced Convulsion.
Hu et al., Wuhan, China. In Chin Med J (engl), 2014
In this study, we examined the potential changes in NCX3 in the hippocampus and cerebrocortex of rats with hyperthermia-induced convulsion.
The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.
Review
Khananshvili, Tel Aviv-Yafo, Israel. In Mol Aspects Med, 2013
Three mammalian genes (SLC8A1, SLC8A2, and SLC8A3) and their splice variants are expressed in a tissue-specific manner to mediate Ca(2+)-fluxes across the cell-membrane and thus, significantly contribute to regulation of Ca(2+)-dependent events in many cell types.
Human macrophages and monocytes express functional Na(+)/Ca (2+) exchangers 1 and 3.
Review
Marone et al., Napoli, Italy. In Adv Exp Med Biol, 2012
A family of three genes (NCX1, NCX2, and NCX3) has been identified in neurons and muscle cells.
New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes.
Review
Annunziato et al., Napoli, Italy. In Adv Exp Med Biol, 2012
Similarly, NCX activity and NCX1 protein expression were significantly enhanced in BV2 microglia exposed to oxygen and glucose deprivation, whereas NCX2 and NCX3 were downregulated.
Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms.
Review
Elmaz et al., Jerusalem, Israel. In Adv Exp Med Biol, 2012
We have shown that cyclosporin A (CsA) treatment of NCX1-, NCX2-, or NCX3-transfected HEK 293 cells and non-transfected H9c2, L6, and aortic smooth muscle cells, which express NCX1 protein naturally, reduces NCX surface expression and transport activity but has no impact on total cell NCX protein.
Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation.
GeneRIF
Annunziato et al., Napoli, Italy. In Cell Death Differ, 2012
calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation.
Molecular and functional characterization of the human platelet Na(+) /Ca(2+) exchangers.
GeneRIF
Bose et al., Winnipeg, Canada. In Br J Pharmacol, 2012
Human platelets express K(+) -independent Na(+) /Ca(2+) exchangers NCX1.3, NCX3.2 and NCX3.4.
Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory.
GeneRIF
Annunziato et al., Napoli, Italy. In J Neurosci, 2011
The deletion of the NCX3 gene has detrimental consequences on basal synaptic transmission, long term potentiation regulation, spatial learning, and memory performance.
High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.
GeneRIF
Gylys et al., Los Angeles, United States. In Cell Calcium, 2011
Results demonstrate a selective regulation of NCX1, NCX2 and NCX3 isoforms in Alzheimer's disease cortex, specifically in terminals containing amyloid-beta.
Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.
GeneRIF
Prakash et al., Rochester, United States. In Plos One, 2010
Data suggest that NCX-mediated Ca(2+) fluxes normally exist in human ASM (potentially contributing to rapid Ca(2+) fluxes), and contribute to enhanced [Ca(2+)](i) regulation in airway inflammation.
Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives.
Review
Impact
Di Renzo et al., Napoli, Italy. In Pharmacol Rev, 2004
Different isoforms of NCX, named NCX1, NCX2, and NCX3, have been described in the brain, whereas only one, NCX1, has been found in the heart.
Sodium/calcium exchange: its physiological implications.
Review
Impact
Lederer et al., Baltimore, United States. In Physiol Rev, 1999
Five genes that code for the exchangers have been identified in mammals: three in the Na+/Ca2+ exchanger family (NCX1, NCX2, and NCX3) and two in the Na+/Ca2+ plus K+ family (NCKX1 and NCKX2).
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