gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neuronal calcium sensor 1

NCS-1, neuronal calcium sensor-1, FREQ
mediates increased pohosphinositide turnover and Ca2+ signaling; plays a role in positive regulation of exocytosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, HAD, Recoverin
Papers using NCS-1 antibodies
Targeting of golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components.
Koch Karl-Wilhelm, In PLoS ONE, 2001
... The NCS-1 sequence was excised from an existing vector [47] and inserted into pECFP-N1, pEGFP-N1and pmCherry-N1 vectors (Clontech, Basingstoke, UK) to generate ...
Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells
Mikhaylova Marina et al., In Frontiers in Molecular Neuroscience, 2000
... The following primary antibodies were used: Anti-NCS-1 rabbit (Santa Cruz Biotechnology, Heidelberg, Germany), anti-GFP mouse ...
Papers on NCS-1
Interleukin-11 binds specific EF-hand proteins via their conserved structural motifs.
Permyakov et al., Moscow, Russia. In J Biomol Struct Dyn, Feb 2016
Here we probed specificity of IL-11 to calcium-binding proteins of various types: calcium sensors of the EF-hand family (calmodulin, S100B and neuronal calcium sensors: recoverin, NCS-1, GCAP-1, GCAP-2), calcium buffers of the EF-hand family (S100G, oncomodulin), and a non-EF-hand calcium buffer (α-lactalbumin).
Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens.
Wong et al., Toronto, Canada. In Behav Brain Res, Jan 2016
Neuronal Calcium Sensor-1 (NCS-1) or Frequenin is widely expressed in the nervous system, and involved in neurotransmission, synaptic plasticity and learning.
Chronic social defeat stress increases dopamine D2 receptor dimerization in the prefrontal cortex of adult mice.
Chung et al., Chŏnju, South Korea. In Neuroscience, Jan 2016
Western blot analysis was used to measure the protein expression levels of dopamine D2 receptors (D2Rs), a short (D2S) and a long form (D2L) and, D2R monomers and dimers, dopamine D1 receptors (D1Rs), neuronal calcium sensor-1 (NCS-1) and G protein-coupled receptor-associated sorting protein-1 (GASP-1), and reverse transcription-polymerase chain reaction (RT-PCR) was used to measure the mRNA expression levels of D2S, D2L, D2R monomers and dimers, and D1Rs in different brain areas.
Membrane binding of Neuronal Calcium Sensor-1 (NCS1).
Boisselier et al., Québec, Canada. In Colloids Surf B Biointerfaces, Jan 2016
UNASSIGNED: Neuronal Calcium Sensor-1 (NCS1) belongs to the family of Neuronal Calcium Sensor (NCS) proteins.
Implications of gamma band activity in the pedunculopontine nucleus.
Urbano et al., Little Rock, United States. In J Neural Transm, Dec 2015
In addition, neuronal calcium sensor protein-1 (NCS-1), which is over expressed in schizophrenia and bipolar disorder, may be responsible for the dysregulation in gamma band activity in at least some patients with these diseases.
Effects of the C-Terminal Tail on the Conformational Dynamics of Human Neuronal Calcium Sensor-1 Protein.
Zhang et al., Shanghai, China. In J Phys Chem B, Dec 2015
Neuronal calcium sensor-1 (NCS-1) protein has been implicated in multiple neuronal functions by binding partners mostly through a largely exposed hydrophobic crevice (HC).
Early avoidance of a heroin-paired taste-cue and subsequent addiction-like behavior in rats.
Levenson et al., State College, United States. In Brain Res Bull, Nov 2015
The results show that the greatest heroin-induced suppression of intake of a saccharin cue is associated with the greatest vulnerability to later addiction-like behavior and to differences in the expression of WLS, β-catenin, and NCS-1 in brain compared to rats that exhibited the least suppression of intake of the heroin-paired cue and/or saline controls.
Mechanisms of Intracellular Calcium Homeostasis in MC3T3-E1 Cells and Bone Tissues of Sprague-Dawley Rats Exposed to Fluoride.
Jing et al., Changchun, China. In Biol Trace Elem Res, Sep 2015
We also found that the low dose of fluoride led to high expression levels of Cav1.2, NCS-1, and PMCA and low expression levels of IP3R and SERCA2b/ATP2A2, while the high dose of fluoride induced an increase in SERCA2b/ATP2A2 levels and decrease in Cav1.2,
Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice.
Liss et al., Ulm, Germany. In Sci Rep, 2014
Moreover, juvenile Cav1.3 KO but not WT mice displayed adult wildtype-like, sensitised inhibitory dopamine-D2-autoreceptor (D2-AR) responses that depended upon both, interaction of the neuronal calcium sensor NCS-1 with D2-ARs, and on voltage-gated T-type calcium channel (TTCC) activity.
Self-directed exploration provides a Ncs1-dependent learning bonus.
Roder et al., Toronto, Canada. In Sci Rep, 2014
We found elevated expression of neuronal calcium sensor 1 (Ncs1) and dopamine type-2 receptors upon self-directed exploration, in concert with increased neuronal activity in the hippocampal dentate gyrus and area CA3, as well as the nucleus accumbens.
Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep.
Garcia-Rill et al., Buenos Aires, Argentina. In Front Neurol, 2013
Our latest results suggest that (1) the manifestation of gamma band activity during waking may employ a separate intracellular pathway compared to that during REM sleep, (2) neuronal calcium sensor (NCS-1) protein, which is over expressed in schizophrenia and bipolar disorder, modulates gamma band oscillations in the PPN in a concentration-dependent manner, (3) leptin, which undergoes resistance in obesity resulting in sleep dysregulation, decreases sodium currents in PPN neurons, accounting for its normal attenuation of waking, and (4) following our discovery of electrical coupling in the RAS, we hypothesize that there are cell clusters within the PPN that may act in concert.
Zholos, Kiev, Ukraine. In Handb Exp Pharmacol, 2013
Moreover, TRPC5 functions in partnership with about 60 proteins, including TRPC1, TRPC4, calmodulin, IP3 receptors, NHERF, NCS-1, junctate, stathmin 2, Ca(2+)-binding protein 1, caveolin, and SESTD1, while its desensitisation is mediated by both protein kinases A and C. TRPC5 has a distinct voltage dependence shared only with its closest relative, TRPC4.
Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1.
Ames et al., Davis, United States. In Front Mol Neurosci, 2013
Retinal recoverin controls Ca(2) (+)-dependent inactivation of light-excited rhodopsin during phototransduction, guanylyl cyclase activating proteins 1 and 2 (GCAP1 and GCAP2) promote Ca(2) (+)-dependent activation of retinal guanylyl cyclases, and neuronal frequenin (NCS-1) modulates synaptic activity and neuronal secretion.
Differential effects of swimming training on neuronal calcium sensor-1 expression in rat hippocampus/cortex and in object recognition memory tasks.
Massensini et al., Belo Horizonte, Brazil. In Brain Res Bull, 2012
physical exercise could be modulating NCS-1 in an activity dependent manner, for specific neural substrates
The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺₋ activated state.
Kragelund et al., Copenhagen, Denmark. In J Mol Biol, 2012
the C-terminal tail is important for regulating the conformational stability of NCS1 in Ca(2+)-activated state
Dopamine receptor interacting proteins: targeting neuronal calcium sensor-1/D2 dopamine receptor interaction for antipsychotic drug development.
Levenson et al., Fairfax, United States. In Curr Drug Targets, 2012
[review] Receptor interaction properties in schizophrenia are dependent upon NCS-1, a protein found to regulate the phosphorylation, trafficking, and signaling profile of the D2 dopamine receptor (D2R) in neurons.
Role of neuronal calcium sensor-1 in the cardiovascular system.
Wakabayashi et al., Ōsaka, Japan. In Trends Cardiovasc Med, 2012
Neuronal Ca(2+) sensor-1 (NCS-1) is an EF-hand Ca(2+)-binding protein that is highly expressed in young hearts; however, little is known about its cardiac functions.
Interaction between the D2 dopamine receptor and neuronal calcium sensor-1 analyzed by fluorescence anisotropy.
Flanagan et al., United States. In Biochemistry, 2011
analysis of the interaction between the D2 dopamine receptor and neuronal calcium sensor-1
Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.
Ehrlich et al., New Haven, United States. In J Biol Chem, 2011
it is possible to protect cells from paclitaxel-induced degradation of NCS-1 by inhibiting calpain activity
Neuronal calcium sensor 1 and activity-dependent facilitation of P/Q-type calcium currents at presynaptic nerve terminals.
Takahashi et al., Tokyo, Japan. In Science, 2002
We investigated whether neuronal calcium sensor 1 (NCS-1) may underlie this phenomenon.
share on facebooktweetadd +1mail to friends