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NCK adaptor protein 2

Nck2, Grb4, Nckbeta
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Nck, Actin, V1a, Src, CAN
Papers using Nck2 antibodies
Physical and functional association of c-Src and adhesion and degranulation-promoting adaptor protein (ADAP) inosteoclastogenesis in vitro.
Supplier
Rénia Laurent, In PLoS ONE, 2004
... phosphotyrosine (p-Tyr100, Cell Signaling Technologies, Inc., Danvers, USA), Fyn (CST, #4023), Nck (recognizing Nck1 and Nck2, Becton Dickinson GmbH, Heidelberg, Germany, #610099), ...
Papers on Nck2
Renal microRNA- and RNA-profiles in progressive chronic kidney disease.
New
Mayer et al., Innsbruck, Austria. In Eur J Clin Invest, Jan 2016
In particular miR-206 and miR-532-3p were associated with distinct biological processes via the expression of their target mRNAs: Reduced expression of miR-206 in progressive disease correlated with the upregulation of target mRNAs participating in inflammatory pathways (CCL19, CXCL1, IFNAR2, NCK2, PTK2B, PTPRC, RASGRP1, and TNFRSF25).
Nck influences preosteoblastic/osteoblastic migration and bone mass.
New
Ezura et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, Jan 2016
Nck (noncatalytic region of tyrosine kinase; collectively referred to Nck1 and Nck2) is a member of the signaling adaptors that regulate cell migration and cytoskeletal structures, but its function in cells in the osteoblastic lineage is not known.
Evidence for inducible recruitment of Wiskott-Aldrich syndrome protein to T cell receptor-CD3 complex in Jurkat T cells.
New
Pongcharoen et al., Phitsanulok, Thailand. In Asian Pac J Allergy Immunol, Sep 2015
METHODS: Jurkat T cells were stimulated with anti-TCR antibody and then the cell lysates were immunoprecipitated with anti-CD3 antibody before immunoblotting with antibodies specific to WASp, Nck1, Nck2, SLP-76 and CD3ε molecules.
NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits.
New
Fawcett et al., Halifax, Canada. In J Neurochem, Sep 2015
We suggest that DCC signaling functions through NCK1 and NCK2 and that both proteins are necessary for the establishment of normal spinal circuits necessary for gait.
Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway.
New
Ingley et al., Australia. In Oncogene, Aug 2015
AFAP1L1 intersects several invadopodia pathway components through its multiple domains and motifs, including the following (i) pleckstrin homology domains that bind phospholipids generated at the plasma membrane by phosphoinositide 3-kinase, (ii) a direct filamentous-actin binding domain and (iii) phospho-tyrosine motifs (pY136 and pY566) that specifically bind Vav2 and Nck2 SH2 domains, respectively.
Targeting of the EGFR/β1 integrin connecting proteins PINCH1 and Nck2 radiosensitizes three-dimensional SCC cell cultures.
New
Cordes et al., Dresden, Germany. In Oncol Rep, Jul 2015
In the present study, we analyzed the role of two of these adapter proteins, called PINCH1 and Nck2, for cellular radioresistance in combination with EGFR-targeting using the monoclonal antibody cetuximab.
The adapter proteins ADAP and Nck cooperate in T cell adhesion.
Janssen et al., Kiel, Germany. In Mol Immunol, 2014
Employing co-immunoprecipitations, we demonstrate that both Nck family members Nck1 and Nck2 coprecipitate with ADAP.
DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.
Fukui et al., Tokyo, Japan. In J Exp Med, 2014
Instead, DOCK5 associated with Nck2 and Akt to regulate microtubule dynamics through phosphorylation and inactivation of GSK3β.
Inhibitory effects of α-cyperone on adherence and invasion of avian pathogenic Escherichia coli O78 to chicken type II pneumocytes.
Wei et al., Changchun, China. In Vet Immunol Immunopathol, 2014
In addition, α-cyperone inhibited actin cytoskeleton polymerization induced by APEC-O78 through down regulating the expression of Nck-2, Cdc42 and Rac1.
Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.
Pongcharoen et al., Phitsanulok, Thailand. In Cell Commun Signal, 2013
Nck1 and Nck2 are two highly related adaptor proteins downstream of the TCR that each contains three SH3 and one SH2 domains.
Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.
Mundel et al., Boston, United States. In Nat Commun, 2012
Here we show that Nck1, but not Nck2, is a substrate of c-Cbl-mediated ubiquitination.
p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
GeneRIF
Barnier et al., Gif-sur-Yvette, France. In J Biol Chem, 2011
p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology.
GeneRIF
Sun et al., New Haven, United States. In Mol Cell Neurosci, 2011
Data show that only Nck2 is required for the Slit1-induced changes in cortical neuron morphology in vitro.
[A uNick protein].
GeneRIF
Larose et al., Montréal, Canada. In Med Sci (paris), 2011
Nck2 is an adaptor protein composed of 3N-SH3 domains followed by a unique Cterminal SH2 domain. It interacts with PINCH in integrin signal transduction, cell migratio and survival. Review.
Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo.
GeneRIF
Larose et al., Montréal, Canada. In Bmc Cancer, 2010
Nck2 effectively influences human melanoma phenotype progression.
Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing.
GeneRIF
Senga et al., Nagoya, Japan. In Febs J, 2010
The Cas utilizes Nck2 to activate Cdc42 and induce cell polarization in response to wound healing.
Integrins and proximal signaling mechanisms in cardiovascular disease.
Review
Dostal et al., Dallas, United States. In Front Biosci, 2008
In addition to their structural functions, integrins mediate signaling from the extracellular space into the cell through integrin-associated signaling and adaptor molecules such as FAK (focal adhesion kinase), ILK (integrin-linked kinase), PINCH (particularly interesting new cysteine-histidine rich protein) and Nck2 (non-catalytic (region of) tyrosine kinase adaptor protein-2).
Signalling via integrins: implications for cell survival and anticancer strategies.
Review
Cordes et al., Dresden, Germany. In Biochim Biophys Acta, 2007
In addition to their structural functions, integrins mediate signalling from the extracellular space into the cell through integrin-associated signalling and adaptor molecules such as FAK (focal adhesion kinase), ILK (integrin-linked kinase), PINCH (particularly interesting new cysteine-histidine rich protein) and Nck2 (non-catalytic (region of) tyrosine kinase adaptor protein 2).
The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.
Impact
GeneRIF
Henkemeyer et al., Dallas, United States. In Nature, 2001
Transduces B-ephrin reverse signals.
The SH2 and SH3 adapter Nck: a two-gene family and a linker between tyrosine kinases and multiple signaling networks.
Review
She et al., Los Angeles, United States. In Histol Histopathol, 2000
Nckalpha and Nckbeta are expressed in the same cells and appear to have distinct signaling specificity.
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