Nck influences preosteoblastic/osteoblastic migration and bone mass.
Tokyo, Japan. In Proc Natl Acad Sci U S A, Jan 2016
Nck (noncatalytic region of tyrosine kinase; collectively referred to Nck1 and Nck2) is a member of the signaling adaptors that regulate cell migration and cytoskeletal structures, but its function in cells in the osteoblastic lineage is not known.
Targeting the Wnt signaling pathway in colorectal cancer.
Kōbe, Japan. In Expert Opin Ther Targets, Nov 2015
TRAF2 and NCK-interacting protein kinase (TNIK) was identified as the most downstream regulator of Wnt signaling by two independent research groups, and several classes of small-molecule inhibitors targeting this protein kinase have been developed.
Roles of adaptor proteins in podocyte biology.
Ch'ŏngju, South Korea. In World J Nephrol, 2013
These adaptor proteins, such as CD2-associated protein, zonula occludens 1, β-catenin, Nck and p130Cas, located at the intracellular SD insertion area near lipid rafts, have important structural and functional roles.
Phase transitions in the assembly of multivalent signalling proteins.
Dallas, United States. In Nature, 2012
In the case of the actin-regulatory protein called neural Wiskott-Aldrich syndrome protein (N-WASP) interacting with its established biological partners NCK and phosphorylated nephrin, the phase transition corresponds to a sharp increase in activity towards an actin nucleation factor, the Arp2/3 complex.