Nck influences preosteoblastic/osteoblastic migration and bone mass.
Tokyo, Japan. In Proc Natl Acad Sci U S A, Jan 2016
Nck (noncatalytic region of tyrosine kinase; collectively referred to Nck1 and Nck2) is a member of the signaling adaptors that regulate cell migration and cytoskeletal structures, but its function in cells in the osteoblastic lineage is not known.
Roles of adaptor proteins in podocyte biology.
Ch'ŏngju, South Korea. In World J Nephrol, 2013
These adaptor proteins, such as CD2-associated protein, zonula occludens 1, β-catenin, Nck and p130Cas, located at the intracellular SD insertion area near lipid rafts, have important structural and functional roles.
Phase transitions in the assembly of multivalent signalling proteins.
Dallas, United States. In Nature, 2012
In the case of the actin-regulatory protein called neural Wiskott-Aldrich syndrome protein (N-WASP) interacting with its established biological partners NCK and phosphorylated nephrin, the phase transition corresponds to a sharp increase in activity towards an actin nucleation factor, the Arp2/3 complex.
[A uNick protein].
Montréal, Canada. In Med Sci (paris), 2011
Nck1 is an adaptor protein composed of 3 N-terminal SH3 domains followed by a unique Cterminal SH2 domain. It plays a role in cell migration, cell adhesion, actin polymerization, stress responses and cell survival. It is implicated in melanoma. Review.