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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cytochrome b5 reductase 4

Ncb5or, b5+b5R, cb5/cb5r, cytochrome b-type NAD(P)H oxidoreductase
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010] (from NCBI)
Top mentioned proteins: oxidoreductase, ACID, Insulin, AGE, OUT
Papers on Ncb5or
Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase.
Kereszturi et al., Budapest, Hungary. In Biochimie, 2013
NADH cytochrome b5 oxidoreductase (Ncb5or) protects β-cells against oxidative stress and lipotoxicity.
NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death.
Adak et al., Calcutta, India. In J Biol Chem, 2012
NAD(P)H cytochrome b(5) oxidoreductase (Ncb5or), comprising cytochrome b(5) and cytochrome b(5) reductase domains, is widely distributed in eukaryotic organisms.
Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity.
GeneRIF
Lappin et al., Ireland. In J Pediatr Hematol Oncol, 2012
Mutation in cytochrome b5 reductase is associated with developmental delay and severe neurological problems.
Beta-Cell Injury in Ncb5or-null Mice is Exacerbated by Consumption of a High-Fat Diet.
Zhu et al., Guangzhou, China. In Eur J Lipid Sci Technol, 2012
NADH-cytochrome b5 oxidoreductase (Ncb5or) in endoplasmic reticulum (ER) is involved in fatty acid metabolism, and Ncb5or(-/-) mice fed standard chow (SC) are insulin-sensitive but weigh less than wild type (WT) littermates.
Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.
Zhu et al., Kansas City, United States. In Biochim Biophys Acta, 2011
NADH-cytochrome b5 oxidoreductase (Ncb5or) is an endoplasmic reticulum (ER)-associated redox enzyme involved in fatty acid metabolism, and phenotypic abnormalities of Ncb5or(-/-) mice include diabetes and lipoatrophy.
Ncb5or deficiency increases fatty acid catabolism and oxidative stress.
GeneRIF
Zhu et al., Kansas City, United States. In J Biol Chem, 2011
FFA accumulation and catabolism and oxidative stress are major consequences of Ncb5or deficiency in liver.
Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.
GeneRIF
Zhu et al., Kansas City, United States. In J Biol Chem, 2010
Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.
The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity.
GeneRIF
Bunn et al., Boston, United States. In J Lipid Res, 2010
Onset of hyperglycemia in the Chop(-/-);Ncb5or(-/-) mice was delayed two weeks beyond that observed in Chop(+/+);Ncb5or(-/-) mice.
Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes.
GeneRIF
Bunn et al., Boston, United States. In J Biol Chem, 2008
Ncb5or loss results in impaired fatty acid desaturation, lipoatrophy, and diabetes
The reductase NCB5OR is responsive to the redox status in beta-cells and is not involved in the ER stress response.
GeneRIF
Bunn et al., Boston, United States. In Biochem J, 2007
Data suggest that NCB5OR does not appear to be involved in ER stress, although it may be involved in maintaining or regulating the redox status in beta-cells.
Promoter characterization and transcriptional regulation of Ncb5or, a novel reductase necessary for pancreatic beta-cell maintenance.
GeneRIF
Bunn et al., Boston, United States. In Biochim Biophys Acta, 2006
The data presented here identify and characterize the previously unknown promoter of Ncb5or, a reductase critical for beta-cell survival.
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.
GeneRIF
Pedersen et al., Denmark. In Diabetes, 2004
Variaation in the coding region is not a major contributor in the pathogenesis of nonautoimmune diabetes.
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes.
GeneRIF
Bunn et al., Boston, United States. In Proc Natl Acad Sci U S A, 2004
Data suggest that NCB5OR appears to play a critical role in protecting pancreatic beta cells against oxidant stress.
NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum.
GeneRIF
Bunn et al., Boston, United States. In J Biol Chem, 2004
NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum
Identification and characterization of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase.
Aitken et al., Newcastle, Australia. In Genomics, 2004
Cytochrome b5/cytochrome b5 reductase (cb5/cb5r) is a cytosolic fusion protein between the hemoprotein cytochrome b5 and the flavoprotein cytochrome b5 reductase.
p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families.
Valencia et al., Madrid, Spain. In Febs Lett, 2002
We identified families of proteins characterized by the presence of a domain similar to human p23 protein, which include proteins such as Sgt1, involved in the yeast kinetochore assembly; melusin, involved in specific interactions with the cytoplasmic integrin beta1 domain; Rar1, related to pathogenic resistance in plants, and to development in animals; B5+B5R flavo-hemo cytochrome NAD(P)H oxidoreductase type B in humans and mice; and NudC, involved in nucleus migration during mitosis.
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