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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Carcinoembryonic antigen-related cell adhesion molecule 6

Carcinoembryonic antigen (CEA; MIM 114890) is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma. An apparent lack of absolute cancer specificity for CEA probably results in part from the presence in normal and neoplastic tissues of antigens that share antigenic determinants with the 180-kD form of CEA (Barnett et al., 1988 [PubMed 3220478]). For background information on the CEA family of genes, see CEACAM1 (MIM 109770).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CEA, CAN, ACID, CD45, HAD
Papers using NCA antibodies
Biliary Glycoprotein Messenger-Rna Expression Is Increased in Primary Lung-Cancer, Especially in Squamous-Cell Carcinoma.
Navarro Alfons, In PLoS ONE, 1993
... The mAbs 9A6 (specific for CEACAM6) and BAC2 (specific for CEACAM7) were provided by Genovac (Freiburg, Germany) ...
Papers on NCA
Utility of a Bayesian Mathematical Model to Predict the Impact of Immunogenicity on Pharmacokinetics of Therapeutic Proteins.
Jawa et al., Thousand Oaks, United States. In Aaps J, Feb 2016
The concentration-time data from a single dose PK study using five monoclonal antibodies were modeled using a non-compartmental analysis (NCA), one-compartmental, and two-compartmental Michaelis-Menten kinetic model (MMK).
Expression of human carcinoembryonic antigen-related cell adhesion molecule 6 and alveolar progenitor cells in normal and injured lungs of transgenic mice.
Ballard et al., San Francisco, United States. In Physiol Rep, Dec 2015
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is expressed in the epithelium of various primate tissues, including lung airway and alveoli.
A simultaneous semi-mechanistic population analysis of levofloxacin in plasma, lung and prostrate to describe the influence of efflux transporters on drug distribution following intravenous and intratracheal administration.
Dalla Costa et al., Porto Alegre, Brazil. In Antimicrob Agents Chemother, Dec 2015
Plasma and tissue concentration/time profiles were evaluated by non-compartmental (NCA) and population PK analysis.
A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.
Allada et al., Evanston, United States. In Cell, Sep 2015
In the morning, a voltage-independent sodium conductance via the NA/NALCN ion channel depolarizes these neurons.
Novel GABA receptor pesticide targets.
Durkin et al., Berkeley, United States. In Pestic Biochem Physiol, Jun 2015
The target of the first generation (20th century) NCAs differs between the larger or elongated compounds (NCA-IA) including many important insecticides of the past (cyclodienes and polychlorocycloalkanes) or present (fiproles) and the smaller or compact compounds (NCA-IB) highly toxic to mammals and known as cage convulsants, rodenticides or chemical threat agents.
Minireview: Mode of action of meta-diamide insecticides.
Banba et al., Mobara, Japan. In Pestic Biochem Physiol, Jun 2015
Molecular modeling studies revealed that the meta-diamides may bind to an inter-subunit pocket near G336 in the Drosophila RDL GABA receptor better when in the closed state, which is distinct from the NCA-binding site, which is in a channel formed by M2s.
Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.
Sodeoka et al., Wako, Japan. In Acc Chem Res, Jun 2015
From the resulting focused library, we identified a highly selective PP2B inhibitor, NCA-01.
Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive Escherichia coli Bacteria Associated with Crohn's Disease.
Barnich et al., Clermont-Ferrand, France. In Mbio, 2014
These bacteria adhere to mannose residues expressed by CEACAM6 on host cells in a type 1 pilus-dependent manner.
Reconstruction of temporal activity of microRNAs from gene expression data in breast cancer cell line.
Bar et al., Trondheim, Norway. In Bmc Genomics, 2014
RESULTS: In the current study, we combined experimentally verified miRNA-TG interactions with breast cancer microarray TG expression data to identify key miRNAs and compute their temporal activity using network component analysis (NCA).
Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells.
Kalthoff et al., Kiel, Germany. In Bmc Cancer, 2014
Its family member CEACAM6 is also upregulated in adenomas and carcinomas of the colon and an independent predictor of poor survival.
Serum Galectin-9 Levels Are Associated with Coronary Artery Disease in Chinese Individuals.
Zhong et al., Wuhan, China. In Mediators Inflamm, 2014
The effect of Gal-9 on peripheral blood mononuclear cells (PBMC) was investigated in patients with normal coronary artery (NCA).
Recent advances in amino acid N-carboxyanhydrides and synthetic polypeptides: chemistry, self-assembly and biological applications.
Cheng et al., Los Angeles, United States. In Chem Commun (camb), 2014
Functional polypeptides, mostly prepared from novel NCA monomers, with ultra-stable helical conformation, stimuli-sensitive properties, or glycoprotein mimetics are summarized.
Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria.
Hauck et al., Konstanz, Germany. In Cell Commun Signal, 2013
Several family members, including CEACAM1, CEA, and CEACAM6, are found on epithelial tissues throughout the human body.
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis.
Arabzadeh et al., Montréal, Canada. In Cancer Metastasis Rev, 2013
Indeed, CEACAM1, CEACAM5, and CEACAM6 are now considered valid clinical biomarkers and promising therapeutic targets in melanoma, lung, colorectal, and pancreatic cancers.
Characterization of adherent-invasive Escherichia coli isolated from pediatric patients with inflammatory bowel disease.
Stronati et al., Roma, Italy. In Inflamm Bowel Dis, 2012
High CEACAM6 expresssion is associated with inflammatory bowel disease.
Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein.
Lal et al., New Delhi, India. In J Biol Chem, 2012
a novel role for NA in enhancing host cell survival by activating the Src/Akt signaling axis via an interaction with carcinoembryonic antigen-related cell adhesion molecule 6/cluster of differentiation 66c (C6).
Distribution and surfactant association of carcinoembryonic cell adhesion molecule 6 in human lung.
Ballard et al., San Francisco, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
CEACAM6 is expressed by alveolar and airway epithelial cells of human lung and is secreted into lung-lining fluid, where fully glycosylated protein binds to surfactant.
Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae.
Gray-Owen et al., Toronto, Canada. In Infect Immun, 2012
The authors show that the expression of CEACAM1 and CEACAM6 potentiate CEACAM3-dependent responses of neutrophils, exposing a cooperative role for this family of proteins during neisserial infection of neutrophils.
Expression and prognostic significance of CEACAM6, ITGB1, and CYR61 in peripheral blood of patients with gastric cancer.
Wang et al., Hangzhou, China. In J Surg Oncol, 2011
High serum CEACAM6 is associated with gastric cancer.
Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance.
Rochlitz et al., Basel, Switzerland. In J Clin Oncol, 2003
the first study to demonstrate the prognostic relevance of CEACAM6 overexpression in human colorectal cancer
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