Novel GABA receptor pesticide targets.
Berkeley, United States. In Pestic Biochem Physiol, Jun 2015
The target of the first generation (20th century) NCAs differs between the larger or elongated compounds (NCA-IA) including many important insecticides of the past (cyclodienes and polychlorocycloalkanes) or present (fiproles) and the smaller or compact compounds (NCA-IB) highly toxic to mammals and known as cage convulsants, rodenticides or chemical threat agents.
Minireview: Mode of action of meta-diamide insecticides.
Mobara, Japan. In Pestic Biochem Physiol, Jun 2015
Molecular modeling studies revealed that the meta-diamides may bind to an inter-subunit pocket near G336 in the Drosophila RDL GABA receptor better when in the closed state, which is distinct from the NCA-binding site, which is in a channel formed by M2s.