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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


NBS1, Vav, Vav1, p95
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Mre11, Rad50, Atm, CAN, Akt
Papers using NBS1 antibodies
Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation
Maizels Nancy, In PLoS Genetics, 2010
... and anti-P-T68-Chk2 from Cell Signaling Technologies; anti-Chk2 (clone 7) from Upstate; and anti-Mre11, anti-Rad50, and anti-Nbs1 from Novus Biologicals.
betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1
Kim Eung-Gook et al., In The Journal of Cell Biology, 2005
... Anti-GEF-H1 and Vav1 antibodies were obtained from Cell Signaling Technology ...
A death-promoting role for extracellular signal-regulated kinase
Yaffe Michael B et al., In Molecular Systems Biology, 2005
... Antibodies against total ATM and Nbs1 were obtained from Abcam, total H2AX and phospho-p53 ...
Vav1 Phosphorylation Is Induced by β2 Integrin Engagement on Natural Killer Cells Upstream of Actin Cytoskeleton and Lipid Raft Reorganization
Long Eric O. et al., In The Journal of Experimental Medicine, 2002
... The rabbit polyclonal antibodies H-211 to Vav1 and C-19 to PAK (Santa Cruz Biotechnology, Inc.) were used for ...
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Papers on NBS1
The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.
Bohlander et al., München, Germany. In Leukemia, Jan 2016
Vav-Cre induced pan-hematopoietic expression of the CALM/AF10 fusion gene led to acute leukemia with a median latency of 12 months.
Chromatin perturbations during the DNA damage response in higher eukaryotes.
Kastan et al., Pittsburgh, United States. In Dna Repair (amst), Dec 2015
The MRE11-RAD50-NBS1 (MRN) complex, which has a catalytic role in DNA repair, and the KAT5 (Tip60) acetyltransferase are required for maximal ATM kinase activation in cells exposed to low doses of ionizing radiation.
Geographical distribution of genetic diversity in Secale landrace and wild accessions.
Leino et al., Linköping, Sweden. In Bmc Plant Biol, Dec 2015
S. afghanicum (Vav.)
Identification of novel genes and pathways in carotid atheroma using integrated bioinformatic methods.
Dai et al., Guangzhou, China. In Sci Rep, Dec 2015
Protein-protein interaction network and module analysis demonstrated that VAV1, SYK, LYN and PTPN6 may play critical roles in the network.
Integrated molecular analysis of adult T cell leukemia/lymphoma.
Ogawa et al., Kyoto, Japan. In Nat Genet, Nov 2015
Other notable features include a predominance of activating mutations (in PLCG1, PRKCB, CARD11, VAV1, IRF4, FYN, CCR4 and CCR7) and gene fusions (CTLA4-CD28 and ICOS-CD28).
Heterozygous p.I171V mutation of the NBN gene as a risk factor for lung cancer development.
Nowak et al., Poznań, Poland. In Oncol Lett, Nov 2015
UNASSIGNED: The NBN gene, also known as NBS1, is located on the chromosome band 8q21.3, and encodes a 754-amino acid-long protein named nibrin.
Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.
Katzav, Jerusalem, Israel. In Oncotarget, Nov 2015
One of these, Vav1, is normally expressed exclusively in the hematopoietic system, where it functions as a specific GDP/GTP nucleotide exchange factor (GEF), strictly regulated by tyrosine phosphorylation.
Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements.
Haaf et al., Würzburg, Germany. In Mol Syndromol, Sep 2015
Therefore, the putative functions of the proteins encoded by ATM, BLM, WRN, ATR, MRE11, NBS1, and RAD51 in preventing CCRs are discussed.
Viral and Cellular Genomes Activate Distinct DNA Damage Responses.
O'Shea et al., Los Angeles, United States. In Cell, Sep 2015
In response to cellular genome breaks, MRE11/RAD50/NBS1 (MRN) activates a global ATM DNA damage response (DDR) that prevents cellular replication.
2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): a randomised trial.
TRUFFLE study group et al., London, United Kingdom. In Lancet, Jun 2015
We randomly allocated women 1:1:1, with randomly sized blocks and stratified by participating centre and gestational age (<29 weeks vs ≥29 weeks), to three timing of delivery plans, which differed according to antenatal monitoring strategies: reduced cardiotocograph fetal heart rate STV (CTG STV), early DV changes (pulsatility index >95th percentile; DV p95), or late DV changes (A wave [the deflection within the venous waveform signifying atrial contraction] at or below baseline; DV no A).
Weaning Markedly Affects Transcriptome Profiles and Peyer's Patch Development in Piglet Ileum.
Kelly et al., Kyoto, Japan. In Front Immunol, 2014
Genes CXCL13, SLA-DOA (MHC class II), ICAM1, VAV1, and VCAM1 were involved in the pathway Chemotaxis Leukocyte chemotaxis and they were found to significantly change between 14- and 21-day-old suckling piglets and between groups of suckling and weaned piglets.
Functional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis.
Komatsu et al., Kyoto, Japan. In Biomolecules, 2014
NBS1, a product of the mutated gene in NBS, contains several protein interaction domains in the N-terminus and C-terminus.
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.
Stucki et al., Zürich, Switzerland. In Nat Cell Biol, 2014
This is associated with transient recruitment of the Nijmegen breakage syndrome protein 1 (NBS1), a central regulator of DNA damage responses, into the nucleoli.
[The role of ATM kinase in neurodegeneration].
Lasoń et al., In Postepy Biochem, 2013
The pleiotropic effect of ATM kinase requires effective control exercised by, inter alia, proteins having specific binding motifs this kinase, such as ATMIN and NBS1.
Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
Chute et al., Durham, United States. In Nat Med, 2013
Mice with EGFR deficiency in VAV-expressing hematopoietic cells also had delayed recovery of bone marrow stem and progenitor cells after TBI.
Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.
Hearing et al., Stony Brook, United States. In J Virol, 2012
Mre11 and Nbs1 are sumoylated during Ad5 infection and the E4-ORF3 protein is necessary and sufficient to induce SUMO conjugation. Relocalization of Mre11 and Nbs1 into E4-ORF3 nuclear tracks is required for this modification to occur.
Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis.
Katayama et al., Ōsaka, Japan. In J Allergy Clin Immunol, 2012
artemin lowers the threshold of temperature-dependent itch sensation.
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
Fisher et al., New York City, United States. In Plos Genet, 2012
By a chemical-genetic approach study identified Nbs1 as a target of Cdk2, and mapped the phosphorylation to a conserved CDK consensus recognition site.
Haploinsufficiency of the Nijmegen breakage syndrome 1 gene increases mammary tumor latency and metastasis.
Crowe et al., Chicago, United States. In Int J Oncol, 2012
NBS1 haploinsufficiency results in increased mammary tumor latency and metastasis.
The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Veillette et al., Montréal, Canada. In Immunity, 2012
SAP couples SLAM family receptors to the kinase Fyn, which triggered the exchange factor Vav-1 and augmented NK cell activation.
More papers using NBS1 antibodies
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts
Winters Thomas A. et al., In Journal of Nucleic Acids, 2001
... Antibodies to DNA ligase I, Mre11, Rad50, and NBS1 were from GeneTex, Inc ...
Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton
Shattil Sanford J. et al., In The Journal of Cell Biology, 2000
... Antibodies to Fgr, Hck, Lyn, Syk, and Vav1 were from Santa Cruz Biotechnology, Inc., and antibodies to ...
Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
Halazonetis Thanos D. et al., In The Journal of Cell Biology, 1999
... Polyclonal antibodies recognizing Mre11 and NBS1 were obtained from Calbiochem; polyclonal (clone Y11) and monoclonal (clone B11) antibodies recognizing the hemagglutinin (HA) tag were obtained from Santa Cruz Biotechnology, Inc ...
SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling
Weiss Arthur et al., In The Journal of Experimental Medicine, 1998
... ; rabbit anti-Vav serum (Santa Cruz Biotechnology); rabbit anti–α-tubulin serum (Sigma ...
Requirement for the leukocyte-specific adaptor protein SLP-76 for normal T cell development
Reth Michael et al., In The Journal of Experimental Medicine, 1997
... Anti-Vav and anti–Grb-2 rabbit polyclonal antibodies were purchased from Santa Cruz Biotechnology Inc. ...
Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the β2integrin leukocyte function-associated antigen-1
Leibson Paul J. et al., In The Journal of Experimental Medicine, 1995
... Antibodies used in these studies included anti-Vav polyclonal rabbit antisera (Santa Cruz Biotechnology, Inc. ...
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