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Solute carrier family 4, sodium bicarbonate cotransporter, member 4

NBC, NBC1, NBCn1, NBC3, SLC4A4
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, ATPase, V1a, HAD
Papers on NBC
Adjustments of molecular key components of branchial ion and pH regulation in Atlantic cod (Gadus morhua) in response to ocean acidification and warming.
New
Lucassen et al., Bremerhaven, Germany. In Comp Biochem Physiol B Biochem Mol Biol, Mar 2016
Here, we characterized the regulation of transepithelial ion transporters (NKCC1, NBC1, SLC26A6, NHE1 and 2) and ATPases (Na(+)/K(+) ATPase and V-type H(+) ATPase) in gills of Atlantic cod (Gadus morhua) after 4weeks of exposure to ambient and future PCO2 levels (550μatm, 1200μatm, 2200μatm) at optimum (10°C) and summer maximum temperature (18°C), respectively.
Effects of nano bamboo charcoal on PAHs-degrading strain Sphingomonas sp. GY2B.
New
Dang et al., Guangzhou, China. In Ecotoxicol Environ Saf, Mar 2016
Nano bamboo charcoal (NBC) has been commonly used in the production of textiles, plastics, paint, etc.
Aldosterone stimulates the cardiac sodium/bicarbonate cotransporter via activation of the g protein-coupled receptor gpr30.
New
Aiello et al., La Plata, Argentina. In J Mol Cell Cardiol, Dec 2015
The aim of this study was to elucidate if the sodium/bicarbonate cotransporter (NBC) is stimulated by Ald and if the activation of GPR30 mediates this effect.
Common variants in the Na(+)-coupled bicarbonate transporter genes and salt sensitivity of blood pressure: the GenSalt study.
New
Gu et al., Beijing, China. In J Hum Hypertens, Dec 2015
A mixed-effect model was used to assess the additive associations of 76 common variants in five NCBT genes, including SLC4A4, SLC4A5, SLC4A7, SLC4A8 and SLC4A10, with salt sensitivity phenotypes.
Nanobiocatalyst advancements and bioprocessing applications.
Review
New
Jin et al., Kota Kinabalu, Malaysia. In J R Soc Interface, Feb 2015
The nanobiocatalyst (NBC) is an emerging innovation that synergistically integrates advanced nanotechnology with biotechnology and promises exciting advantages for improving enzyme activity, stability, capability and engineering performances in bioprocessing applications.
Regulators of Slc4 bicarbonate transporter activity.
Review
Bevensee et al., Birmingham, United States. In Front Physiol, 2014
The Slc4 family of transporters is comprised of anion exchangers (AE1-4), Na(+)-coupled bicarbonate transporters (NCBTs) including electrogenic Na/bicarbonate cotransporters (NBCe1 and NBCe2), electroneutral Na/bicarbonate cotransporters (NBCn1 and NBCn2), and the electroneutral Na-driven Cl-bicarbonate exchanger (NDCBE), as well as a borate transporter (BTR1).
Prediction of Protein-Protein Interaction Sites Based on Naive Bayes Classifier.
Yan et al., Nanjing, China. In Biochem Res Int, 2014
Here we creatively used a 181-dimension protein sequence feature vector as input to the Naive Bayes Classifier- (NBC-) based method to predict interaction sites in protein-protein complexes interaction.
Structure and Function of SLC4 Family [Formula: see text] Transporters.
Chen et al., Wuhan, China. In Front Physiol, 2014
The solute carrier SLC4 family consists of 10 members, nine of which are [Formula: see text] transporters, including three Na(+)-independent Cl(-)/[Formula: see text] exchangers AE1, AE2, and AE3, five Na(+)-coupled [Formula: see text] transporters NBCe1, NBCe2, NBCn1, NBCn2, and NDCBE, as well as "AE4" whose Na(+)-dependence remains controversial.
Cation-coupled bicarbonate transporters.
Review
Lee et al., Århus, Denmark. In Compr Physiol, 2014
There are currently five mammalian NCBTs in the SLC4-family: the electrogenic Na,HCO3-cotransporters NBCe1 and NBCe2 (SLC4A4 and SLC4A5 gene products); the electroneutral Na,HCO3-cotransporter NBCn1 (SLC4A7 gene product); the Na(+)-driven Cl,HCO3-exchanger NDCBE (SLC4A8 gene product); and NBCn2/NCBE (SLC4A10 gene product), which has been characterized as an electroneutral Na,HCO3-cotransporter or a Na(+)-driven Cl,HCO3-exchanger.
Intracellular pH regulation by acid-base transporters in mammalian neurons.
Review
Parker et al., United States. In Front Physiol, 2013
(3) The properties and importance of members of the SLC4 and SLC9 families of acid-base transporters expressed in the brain that contribute to J L (namely the Cl-HCO3 exchanger AE3) and J E (the Na-H exchangers NHE1, NHE3, and NHE5 as well as the Na(+)- coupled HCO3 (-) transporters NBCe1, NBCn1, NDCBE, and NBCn2).
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.
Review
Impact
Boron et al., Cleveland, United States. In Physiol Rev, 2013
In this review, we mainly focus on the five mammalian NCBTs-NBCe1, NBCe2, NBCn1, NDCBE, and NBCn2.
Role of AE2 for pHi regulation in biliary epithelial cells.
Review
Medina et al., Pamplona, Spain. In Front Physiol, 2012
On the other hand, both Ae2 (+/+) a,b and Ae2 (-/-) a,b mouse cholangiocytes exhibited a Cl(-)-independent bicarbonate transport system, essentially a Na(+)-bicarbonate cotransport (NBC) system, which could contribute to pHi regulation in the absence of AE2.
IRBIT reduces the apparent affinity for intracellular Mg²⁺ in inhibition of the electrogenic Na⁺-HCO₃⁻ cotransporter NBCe1-B.
GeneRIF
Ishikawa et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
these results suggest that IRBIT may reduce the apparent affinity for Mg(2+)(i) in inhibition of NBCe1-B activity in mammalian cells.
Binding of carbonic anhydrase IX to extracellular loop 4 of the NBCe1 Na+/HCO3- cotransporter enhances NBCe1-mediated HCO3- influx in the rat heart.
GeneRIF
Alvarez et al., La Plata, Argentina. In Am J Physiol Cell Physiol, 2012
study demonstrated that carbonic anhydrase IX forms a complex with extracellular loop 4 of NBCe1, which activates NBCe1-mediated bicarbonate ion influx in the myocardium
Effect of simultaneously replacing putative TM6 and TM12 of human NBCe1-A with those from NBCn1 on surface abundance in Xenopus oocytes.
GeneRIF
Boron et al., Wuhan, China. In J Membr Biol, 2012
Simultaneous switching of the putative transmembrane segment (TM6) and TM12 of NBCe1 for those from NBCn1 severely impairs the expression of the transporter at the plasma membrane.
Expression of TMEM16A and SLC4A4 in human pancreatic islets.
GeneRIF
Sener et al., Barcelona, Spain. In Cell Physiol Biochem, 2011
the regulation of anion fluxes in insulin-producing cells may involve both SLC4A4 and TMEM16A
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.
GeneRIF
Pan et al., Taipei, Taiwan. In Plos One, 2011
Data identified IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes by gene based association scan and gene expression analysis.
Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3.
Impact
Kurtz et al., Los Angeles, United States. In Nat Genet, 2003
Here we report that the visual and auditory systems have a specific requirement for H+ disposal mediated by the sodium bicarbonate cotransporter NBC3 (refs.
An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel.
Impact
Boron et al., New Haven, United States. In Nature, 2000
Here we report the cloning of three variants of an electroneutral Na+/HCO3- cotransporter, NBCn1, from rat smooth muscle.
Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter.
Impact
Boron et al., New Haven, United States. In Nature, 1997
We show that when it is expressed in Xenopus oocytes, this protein is electrogenic, Na+ and HCO3- dependent, and blocked by the anion-transport inhibitor DIDS, and conclude that it is the renal electrogenic sodium bicarbonate cotransporter (NBC).
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