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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

BRISC and BRCA1 A complex member 1

Nba1, MERIT40, C19orf62
Top mentioned proteins: Iris, RAP80, BRE, Ubiquitin, V1a
Papers on Nba1
MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
New
Greenberg et al., Philadelphia, United States. In Genes Dev, Oct 2015
MERIT40 is an essential component of the RAP80 ubiquitin recognition complex that targets BRCA1 to DNA damage sites.
The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.
New
van Attikum et al., Leiden, Netherlands. In Nucleic Acids Res, Sep 2015
DSBs elicit a signaling cascade involving the E3 ubiquitin ligases RNF8/RNF168 and the ubiquitin-dependent assembly of the BRCA1-Abraxas-RAP80-MERIT40 complex.
MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy.
New
Toker et al., Boston, United States. In Cell Rep, Jul 2015
We identify MERIT40, a component of the BRCA1-A DNA damage repair complex, as an Akt substrate that is phosphorylated following doxorubicin treatment.
MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling.
New
Tong et al., Philadelphia, United States. In Blood, Apr 2015
Here, we show that MERIT40 (Mediator of RAP80 Interactions and Targeting 40 kDa [M40]), a core subunit of an Lnk-associated Lys63 deubiquitinating (DUB) complex, attenuates HSC expansion.
Structural and functional characterization of the MERIT40 to understand its role in DNA repair.
Varma et al., Mumbai, India. In J Biomol Struct Dyn, 2014
MERIT40 (MEdiator of RAP80 Interaction and Targeting 40) is a novel associate of the BRCA1-complex and plays an essential role in DNA damage repair.
A memory system of negative polarity cues prevents replicative aging.
Impact
Pereira et al., Heidelberg, Germany. In Cell, 2014
We revealed a two-step mechanism of loading the Cdc42 antagonist Nba1 into CRMs to mark these compartments as refractory for a second round of Cdc42 activation.
Role of MERIT40 in stabilization of BRCA1 complex: a protein-protein interaction study.
Varma et al., Mumbai, India. In Biochem Biophys Res Commun, 2014
MERIT40 is a novel associate of the BRCA1-complex, thus play an essential role in DNA damage repair mechanism.
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.
Zervos et al., Orlando, United States. In Biochim Biophys Acta, 2012
The BRISC enzyme has a Lys63-linked deubiquitinating activity and is comprised of four known subunits: MERIT40 (mediator of Rap80 interactions and targeting 40kDa), BRE (brain and reproductive organ-expressed), BRCC36 (BRCA1/BRCA2-containing complex, subunit 3) and Abro1.
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.
Impact
Sicheri et al., Toronto, Canada. In Cell, 2012
Structural and sequence information allows us to also predict and validate other Tankyrase targets, including Disc1, Striatin, Fat4, RAD54, BCR, and MERIT40.
Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes.
Nathanson et al., Philadelphia, United States. In Cancer Res, 2011
A cohort of 2,825 BRCA1 mutation carriers was used to evaluate the association of haplotypes at ATM, BRCC36, BRCC45 (BRE), BRIP1 (BACH1/FANCJ), CTIP, ABRA1 (FAM175A), MERIT40, MRE11A, NBS1, PALB2 (FANCN), RAD50, RAD51, RAP80, and TOPBP1, and was associated with time to breast and ovarian cancer diagnosis.
Germline mutational analysis of the C19orf62 gene in African-American women with breast cancer.
GeneRIF
Huo et al., Chicago, United States. In Breast Cancer Res Treat, 2011
findings suggest that germline deleterious mutations in C19orf62 should be rare or absent in familial and nonfamilial breast cancer women
NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes.
GeneRIF
Wang et al., Houston, United States. In J Biol Chem, 2011
NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes
The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments.
Chen et al., Houston, United States. In J Biol Chem, 2010
We and others showed previously that BRCC36 is a component of the BRCA1-A complex, which consists of RAP80, CCDC98/ABRAXAS, BRCC45/BRE, MERIT40/NBA1, BRCC36, and BRCA1.
Common variants at 19p13 are associated with susceptibility to ovarian cancer.
Impact
GeneRIF
Gayther et al., Cambridge, United Kingdom. In Nat Genet, 2010
Single nucleotide polymorphism in MERIT40 is associated with ovarian cancer.
Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families.
GeneRIF
Winqvist et al., Oulu, Finland. In Breast Cancer Res Treat, 2010
germline mutations in MERIT40 are rare or absent in familial breast cancer patients.
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
GeneRIF
Elledge et al., Boston, United States. In Genes Dev, 2009
NBA1 is required to maintain BRE and Abra1 abundance and for the recruitment of BRCA1 to sites of DNA damage. In depth bioinformatics analysis revealed that the BRCA1 A complex bears striking similarities to the 19S proteasome complex.
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