gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Contactin 6

NB-3, Cntn6
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: contactin, Nb2, ACID, HAD, BIG2
Papers on NB-3
Possible mechanism of BN fullerene formation from a boron cluster: Density-functional tight-binding molecular dynamics simulations.
New
Ohta, Nara, Japan. In J Comput Chem, Feb 2016
Most of the incident N atoms are promptly incorporated into the target cluster to form B-N-B bridges or NB3 pyramidal local substructures.
T-Brain-1--A Potential Master Regulator in Autism Spectrum Disorders.
New
Hsueh et al., Taipei, Taiwan. In Autism Res, Aug 2015
A further five of the 24 genes (Cd44, Cdh8, Cntn6, Gpc6, and Ntng1) encode membrane proteins that regulate cell adhesion and axonal outgrowth.
Intercalation of highly dispersed metal nanoclusters into a layered metal oxide for photocatalytic overall water splitting.
New
Maeda et al., Tokyo, Japan. In Angew Chem Int Ed Engl, Mar 2015
Metal nanoclusters (involving metals such as platinum) with a diameter smaller than 1 nm were deposited on the interlayer nanospace of KCa2 Nb3 O10 using the electrostatic attraction between a cationic metal complex (e.g., [Pt(NH3 )4 ]Cl2 ) and a negatively charged two-dimensional Ca2 Nb3 O10 (-) sheet, without the aid of any additional reagent.
CNTN6 copy number variations in 14 patients: a possible candidate gene for neurodevelopmental and neuropsychiatric disorders.
Surti et al., Pittsburgh, United States. In J Neurodev Disord, 2014
Copy number variations of contactin genes (CNTNs), including CNTN3, CNTN4, CNTN5, and CNTN6, have been suggested to be associated with these disorders.
ABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertib.
Cinatl et al., Frankfurt am Main, Germany. In Bmc Res Notes, 2014
RESULTS: The tozasertib concentration that reduces cell viability by 50% (IC50) was dramatically increased in ABCG2-transduced UKF-NB-3(ABCG2) cells (48.8-fold) compared to UKF-NB-3 cells and vector-transduced control cells.
Identification of miRNAs contributing to neuroblastoma chemoresistance.
Vandesompele et al., Malta. In Comput Struct Biotechnol J, 2014
METHODS: Individual subcultures of chemosensitive SH-SY5Y and UKF-NB-3 cells were rendered chemoresistant to doxorubicin (SH-SY5Y, UKF-NB-3) or etoposide (SH-SY5Y).
A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.
Gettemans et al., Gent, Belgium. In Nucleic Acids Res, 2014
Nb3 preferentially binds 'structural' mutant p53, i.e.
A candidate gene association study further corroborates involvement of contactin genes in autism.
Poot, Utrecht, Netherlands. In Mol Syndromol, 2014
In the ASD cohort, a combination of risk alleles of SNPs in CNTN6 (rs9878022 [A]; OR = 3.749) and in CNTNAP2 (rs7804520 [G]; OR = 2.437) was found more frequently than would be expected under random segregation, albeit this association was not statistically significant.
Trisomy 1q41-qter and monosomy 3p26.3-pter in a family with a translocation (1;3): further delineation of the syndromes.
Morán-Barroso et al., Villa Cuauhtémoc, Mexico. In Bmc Med Genomics, 2013
The implicated chromosomal regions were defined by microarray analysis, the patient had a trisomy 1q41-qter of 30.3 Mb in extension comprising about 240 protein coding genes and a monosomy 3p26.3-pter of 1.7 Mb including only the genes CNTN6 (MIM 607220) and CHL1 (MIM 607416), which have been implicated in dendrite development.
Single gene microdeletions and microduplication of 3p26.3 in three unrelated families: CNTN6 as a new candidate gene for intellectual disability.
Lebedev et al., Tomsk, Russia. In Mol Cytogenet, 2013
microduplication encompassing only the CNTN6 gene.
Contactins in the neurobiology of autism.
Review
Burbach et al., Utrecht, Netherlands. In Eur J Pharmacol, 2013
The contactin (CNTN) family of Ig cell adhesion molecules (IgCAMs) harbours at least three members that have genetically been implicated in autism: CNTN4, CNTN5, and CNTN6.
Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.
GeneRIF
Xiao et al., Beijing, China. In J Biol Chem, 2011
the PTPalpha-mediated increase of NB-3 level at the cell surface represents a novel function of PTPalpha in NB-3 signaling in neural development
Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.
Review
Frei et al., Praha, Czech Republic. In Biochim Biophys Acta, 2011
In contrast, two carbenium ions, ellipticine-13-ylium and ellipticine-12-ylium, derived from two activation ellipticine metabolites, 13-hydroxyellipticine and 12-hydroxyellipticine, generate two major deoxyguanosine adducts in DNA found in the human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells and glioblastoma U87MG cells in vitro and in rat breast carcinoma in vivo.
Synaptic formation in subsets of glutamatergic terminals in the mouse hippocampal formation is affected by a deficiency in the neural cell recognition molecule NB-3.
GeneRIF
Watanabe et al., Nagaoka, Japan. In Neurosci Lett, 2010
NB-3 has key roles in the formation of glutamatergic, but not GABAergic, synapses during postnatal development of the hippocampal formation as well as the cerebellum.
Contribution of the neural cell recognition molecule NB-3 to synapse formation between parallel fibers and Purkinje cells in mouse.
GeneRIF
Watanabe et al., Nagaoka, Japan. In Dev Neurobiol, 2009
Collectively, our results indicate that NB-3 deficiency affects synapse formation during postnatal cerebellar development.
Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer.
GeneRIF
Tonin et al., Montréal, Canada. In Int J Gynecol Cancer, 2009
results do not support the candidacy of CHL1, CNTN6, and CNTN4 as tumor suppressor genes in the 3p26-pter region in ovarian cancer
Contactins: emerging key roles in the development and function of the nervous system.
Review
Watanabe et al., Nagaoka, Japan. In Cell Adh Migr, 2009
The subgroup consists of six members: contactin, TAG-1, BIG-1, BIG-2, NB-2 and NB-3.
Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha.
GeneRIF
Xiao et al., Singapore, Singapore. In Embo J, 2008
Both CHL1 and NB-3 interact with protein tyrosine phosphatase alpha (PTPalpha) and regulate its activity in the developing caudal cortex.
Brain regions and genes affecting postural control.
Review
Strazielle et al., Rouen, France. In Prog Neurobiol, 2007
With the gene deletion technique in mice, specific genes expressed in cerebellum encoding glutamate receptors (Grid2 and Grm1) and other molecules (Prkcc, Cntn6, Klf9, Syt4, and En2) have also been shown to affect postural control.
Notch signaling in gastrointestinal tract (review).
Review
Katoh et al., Japan. In Int J Oncol, 2007
DLL1, DLL3, DLL4, JAG1 and JAG2 with DSL domain are typical Notch ligands, while DNER, F3/Contactin and NB-3 without DSL domain are atypical Notch ligands.
share on facebooktweetadd +1mail to friends