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Solute carrier family 38, member 4

Nat3, ATA3, Slc38a4, Nat3p, SNAT4, NAT5
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, SAI, SA2, CAN, TE2
Papers on Nat3
A human haploid gene trap collection to study lncRNAs with unusual RNA biology.
Pauler et al., Vienna, Austria. In Rna Biol, Jan 2016
De novo assembly from RNA-seq data suggests that LOC100288798 extends 289kb beyond its annotated 3' end and overlaps the downstream SLC38A4 gene.
EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos.
Weber et al., Illkirch-Graffenstaden, France. In Genome Res, Dec 2015
EHMT2 also plays a role in the maintenance of germline-derived DNA methylation at one imprinted locus, the Slc38a4 gene.
Preclinical assessment of early tumor response after irradiation by positron emission tomography with 2-amino-[3-¹¹C]isobutyric acid.
Saga et al., Chiba, Japan. In Oncol Rep, May 2015
Expression of amino acid transporters, SLC38A1, SLC38A2 and SLC38A4, was determined by real-time RT-PCR.
Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS.
Fredriksson et al., Uppsala, Sweden. In J Mol Biol, Apr 2015
To date, six members of the SLC38 family (SNATs) have been characterized and functionally subdivided them into System A (SNAT1, SNAT2 and SNAT4) and System N (SNAT3, SNAT5 and SNAT7).
Spermidine induces autophagy by inhibiting the acetyltransferase EP300.
Kroemer et al., Paris, France. In Cell Death Differ, Mar 2015
The knockdown of only two acetyltransferases (among 43 candidates) had such effects: EP300 (E1A-binding protein p300), which is a lysine acetyltranferase, and NAA20 (N(α)-acetyltransferase 20, also known as NAT5), which catalyzes the N-terminal acetylation of methionine residues.
Dexamethasone treatment of pregnant F0 mice leads to parent of origin-specific changes in placental function of the F2 generation.
Fowden et al., In Reprod Fertil Dev, Mar 2015
In contrast, when F1 females were mated with untreated males, F2 placental clearance of the amino acid analogue 14C-methylaminoisobutyric acid was increased by 75% on Day 19 specifically in dams prenatally exposed to dexamethasone on Days 14-18 (P2 placental Slc38a4 expression was decreased in these dams (P0 dexamethasone treatment had no effect on F2 fetal or placental weights, regardless of lineage.
DNA-Binding Motif of the Imprinted Transcription Factor PEG3.
Kim et al., Baton Rouge, United States. In Plos One, 2014
Among the newly identified targets, we analyzed in detail the two loci, Slc38a2 and Slc38a4, which are known to be involved in neutral amino acid transport.
Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana.
Möhlmann et al., Kaiserslautern, Germany. In Biochim Biophys Acta, 2014
We present the biochemical characterization of two NAT proteins, NAT3 and NAT12 from Arabidopsis thaliana after their heterologous expression in Escherichia coli UraA knockout mutants.
Synthetic glucocorticoid reduces human placental system a transport in women treated with antenatal therapy.
Matthews et al., Manchester, United Kingdom. In J Clin Endocrinol Metab, 2014
However, SLC38A4 was significantly reduced by sGCs at term compared with placentas delivered between 14d-term.
Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.
Zabel et al., Poznań, Poland. In Biomed Pharmacother, 2014
Five genes were significantly upregulated: SLC2A9, SLC16A3, SLC16A14, SLC38A4 and SLC39A8.
In vitro fertilization affects growth and glucose metabolism in a sex-specific manner in an outbred mouse model.
Rinaudo et al., San Francisco, United States. In Biol Reprod, 2014
Expression of candidate imprinted genes (H19, Igf2, and Slc38a4) in multiple adult tissues did not show differences among the groups; only Slc38a4 was down-regulated following IVF (in both culture conditions) in female adipose tissue.
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.
Fredriksson et al., Uppsala, Sweden. In Mol Aspects Med, 2013
The most well characterized genes within these families are the vesicular inhibitory amino acid transporter (VIAAT, SLC32A1), PAT1 (SLC36A1), PAT2 (SLC36A2), PAT4 (SLC36A4), SNAT1 (SLC38A1), SNAT2 (SLC38A2), SNAT3 (SLC38A3), and SNAT4 (SLC38A4).
Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein.
Jiang et al., San Antonio, United States. In J Biol Chem, 2011
Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein
Peptide mimic isolated by autoantibody reveals human arrest defective 1 overexpression is associated with poor prognosis for colon cancer patients.
Shou et al., Beijing, China. In Am J Pathol, 2010
These results indicate that ARD1A is a novel tumor-associated antigen and a potential prognostic factor for colon cancer.
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Hung et al., Houston, United States. In Sci Signal, 2009
ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development
Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity.
Lillehaug et al., Bergen, Norway. In J Biol Chem, 2009
Nat5 displays both protein N alpha- and N epsilon-acetyltransferase activity.
The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane.
Glazier et al., Manchester, United Kingdom. In J Physiol, 2009
the contribution of SNAT4 to system A-mediated placental microvillous transport decreases between first trimester and term
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family.
Erickson et al., Boston, United States. In Pflugers Arch, 2004
Transport of small, aliphatic amino acids by System A subtypes (SNAT1, SNAT2, and SNAT4) is rheogenic and pH sensitive.
Composition and function of the eukaryotic N-terminal acetyltransferase subunits.
Sherman et al., Rochester, United States. In Biochem Biophys Res Commun, 2003
Saccharomyces cerevisiae contains three N-terminal acetyltransferases (NATs), NatA, NatB, and NatC, composed of the following catalytic and auxiliary subunits: Ard1p and Nat1p (NatA); Nat3p and Mdm20p (NatB); and Mak3p, Mak10, and Mak31p (NatC).
N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins.
Sherman et al., Rochester, United States. In J Mol Biol, 2003
Those and other putative acetyltransferases were assigned by phylogenetic analysis to the following six protein families: Ard1p; Nat3p; Mak3p; CAM; BAA; and Nat5p.
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