Omega-3 Fatty Acids and Age-Related Macular Degeneration.
Manchester, United Kingdom. In Ophthalmic Res, Dec 2015
Epidemiological studies had indicated potential preventative effects of omega-3, and an earlier randomised prospective study (NAT2) showed that patients who achieved high red blood cell membrane EPA/DHA (eicosapentaenoic acid/docosahexaenoic acid) levels were significantly protected against AMD compared with those with permanently low EPA/DHA levels.
[The role of pharmacogenomics in the tuberculosis treatment regime].
Lima, Peru. In Rev Peru Med Exp Salud Publica, Dec 2015
Drug metabolism is directly related to the genetic variation of NAT2 and CYP2E1 (associated with INH metabolism) and AADAC (associated with RIF metabolism), and the effects produced in an individual may be a fast, intermediate or slow metobolizer.
Pharmacogenetics of isoniazid-induced hepatotoxicity.
Yogyakarta, Indonesia. In Drug Metab Rev, May 2015
We selected English articles of studies in human from PubMed up to May 2014 with the keywords pharmacogenetic, isoniazid and hepatotoxicity, N-acetyl transferase 2 (NAT2), CYP2E1 and glutathione S transferase (GST).
Genetic susceptibility in childhood acute leukaemias: a systematic review.
Rio de Janeiro, Brazil. In Ecancermedicalscience, 2014
We observed that the most frequently investigated genes were: NQO1, GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, CYP2D6, CYP2E1, MDR1 (ABCB1), XRCC1, ARID5B, and IKZF1.
A genome-wide association study of metabolic traits in human urine.
München, Germany. In Nat Genet, 2011
Variants at three of these loci have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria.