NAP-1, Nucleosome assembly protein 1, a histone chaperone involved in Drosophila telomeres.
Barcelona, Spain. In Insect Biochem Mol Biol, Jan 2016
Here, we describe for the first time, the implication of NAP-1 (Nucleosome assembly protein 1), a histone chaperone that has been involved in nuclear transport, transcription regulation, and chromatin remodeling, in telomere biology.
Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action.
São Mamede de Infesta, Portugal. In Pharmacol Res Perspect, Mar 2015
Data reviewed here suggest that ESL and eslicarbazepine demonstrated the following in animal models: (1) the selectivity of interaction with the inactive state of the voltage-gated sodium channel (VGSC), (2) reduction in VGSC availability through enhancement of slow inactivation, instead of alteration of fast inactivation of VGSC, (3) the failure to cause a paradoxical upregulation of persistent Na(+) current (I NaP), and (4) the reduction in firing frequencies of excitatory neurons in dissociated hippocampal cells from patients with epilepsy who were pharmacoresistant to carbamazepine (CBZ).
Nap sleep spindle correlates of intelligence.
Budapest, Hungary. In Sci Rep, 2014
Sleep spindle regulation underlies a circadian rhythm, however the association between spindles and intelligence has not been investigated in daytime nap sleep so far.