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N-acetylneuraminic acid phosphatase

NANP
The protein encoded by this gene is an enzyme involved in the synthesis of N-acetylneuraminate (Neu5Ac), the main form of sialic acid. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Phosphogluconate Dehydrogenase, AGE, ACID
Papers on NANP
Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains.
New
Narum et al., Rockville, United States. In Infect Immun, Oct 2015
The extended rod-like Plasmodium falciparum circumsporozoite protein (CSP) is comprised of three primary domains: a charged N terminus that binds heparan sulfate proteoglycans, a central NANP repeat domain, and a C terminus containing a thrombospondin-like type I repeat (TSR) domain.
Head-to-Head Comparison of Soluble vs. Qβ VLP Circumsporozoite Protein Vaccines Reveals Selective Enhancement of NANP Repeat Responses.
Dutta et al., Silver Spring, United States. In Plos One, 2014
RTS,S, the most advanced malaria vaccine candidate consists of the central NANP repeat and carboxy-terminal region of CSP displayed on a hepatitis B virus-like particle (VLP).
Genetic determinants of anti-malarial acquired immunity in a large multi-centre study.
MalariaGEN Consortium et al., Dakar, Senegal. In Malar J, 2014
DNA was extracted and typed for 202 Single Nucleotide Polymorphisms with known associations to malaria or antibody production, and antibody levels to four clinical grade malarial antigens [AMA1, MSP1, MSP2, and (NANP)4] plus total IgE were measured by ELISA techniques.
Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile protection as an endpoint.
Dutta et al., Silver Spring, United States. In Clin Vaccine Immunol, 2013
Constructs that induced high NANP repeat-specific antibody titers in enzyme-linked immunosorbent assays were protective, and the degree of protection was dependent on the antigen dose.
A chemiluminescent-western blot assay for quantitative detection of Plasmodium falciparum circumsporozoite protein.
Kumar et al., Rockville, United States. In J Immunol Methods, 2013
falciparum CSP monoclonal antibody (mAb 2A10) with the NANP-repeat units on PfCSP.
Full-length Plasmodium falciparum circumsporozoite protein administered with long-chain poly(I·C) or the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion elicits potent antibody and CD4+ T cell immunity and protection in mice.
Seder et al., Bethesda, United States. In Infect Immun, 2013
CS proteins expressed in E. coli induced high-titer antibody responses against the NANP repeat region and potent CSP-specific CD4(+) T cell responses.
T1BT* structural study of an anti-plasmodial peptide through NMR and molecular dynamics.
Lehmann et al., Laramie, United States. In Malar J, 2012
This peptide construct, with B = (NANP)3, has been found to elicit antisporozoite antibodies and gamma-interferon-screening T-cell responses in inbred strains of mice and in outbred nonhuman primates.
Comparative population structure of Plasmodium falciparum circumsporozoite protein NANP repeat lengths in Lilongwe, Malawi.
Juliano et al., Chapel Hill, United States. In Sci Rep, 2012
Humoral immunity to Plasmodium falciparum circumsporozoite protein is partly mediated by a polymorphic NANP tetra-amino acid repeat.
Trueperella pyogenes as cause of a facial abscess in a grey slender loris (Loris lydekkerianus nordicus)--a case report.
Zschöck et al., Gießen, Germany. In Berl Munch Tierarztl Wochenschr, 2012
The T. pyogenes strain could additionally be characterized by PCR-mediated amplification of several known and putative virulence factor encoding genes which revealed the presence of the genes plo encoding pyolysin, nanH encoding neuraminidase NanH and the genes fimA, fimC, fimE encoding the fimbrial subunits FimA, FimC and FimE but not the genes cbpA and nanP encoding collagen-binding protein CbpA and neuraminidase NanP, respectively.
Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex.
Nardin et al., United States. In Front Cell Infect Microbiol, 2011
Antibodies that neutralize infectivity of malaria sporozoites target the central repeat region of the circumsporozoite (CS) protein, which in Plasmodium falciparum is comprised primarily of 30-40 tandem NANP tetramer repeats.
Immunity to Plasmodium falciparum malaria sporozoites by somatic transgene immunization.
Impact
Zanetti et al., San Diego, United States. In Nat Biotechnol, 1997
A single inoculation of plasmid DNA containing an immunoglobulin heavy-chain gene coding in the complementarity-determining region 3 for three repeats of the sequence Asn-Ala-Asn-Pro (NANP), a B-cell epitope of P.falciparum sporozoites, induced antibodies against NANP in all mice.
[Structural studies of malaria vaccine].
Review
Tomita, Ōsaka, Japan. In Yakugaku Zasshi, 1992
1) Peptide vaccines (antigens) of immunodominant tetrapeptide repeats (NANP and NVDP) of the circumsporozoite surface protein of the malaria parasite, Plasmodium falciparum, were genetically produced in E. coli as a fusion protein with a part of human growth hormone, which has affected on the conformations and immunogenicities of the peptide vaccines.
Antibody responses to Plasmodium falciparum and P. vivax sporozoites in areas with stable and unstable malaria.
Review
Tanner et al., Genève, Switzerland. In Bull World Health Organ, 1989
Studies carried out in areas with stable P. falciparum malaria (United Republic of Tanzania) have shown that antibodies against the synthetic peptide (NANP)40 increase as a function of age.
Antisporozoite vaccine for malaria: experimental basis and current status.
Review
Nussenzweig et al., New York City, United States. In Rev Infect Dis, 1989
The sporozoite protein of Plasmodium falciparum has 37-41 repeats of four amino acids: NANP (asparagine-alanine-asparagine-proline).
Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites.
Impact
Gillessen et al., In Nature, 1987
A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine.
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