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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Sodium channel, voltage-gated, type XI, alpha

NAN
Na channel alpha-subunit; may be involved in generation of electrical activity in peripheral sensory neurons [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: 5-HT1A, HAD, ACID, V1a, CAN
Papers using NAN antibodies
Measurement of bond vector orientations in invisible excited states of proteins
Supplier
Sem Daniel S., In PLoS ONE, 2006
... , 100 µM NaN3 in 100% D2O.A smMLCK(p) peptide (NH2-ARRKWQKTGHAVRAIGRLSS-COOH) was purchased from GenScript (Piscataway, NJ) at >98% ...
Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy.
Supplier
Chung Sookja, In PLoS ONE, 2006
... Sodium azide (NaN3), rotenone (Rot), antimycin A (AntA), cycloheximide (CHX) and antinomycin D (ActD) were purchased from Sigma Aldrich (St ...
Methods of digital video microscopy for colloidal studies.
Supplier
Spudich James A., In PLoS Biology, 1995
... Protein was first dialyzed in a PBS buffer with 1 mM EGTA and 0.01 wt% NaN3 (pH 7.5), then biotinylated with sulfo-NHS-biotin (EZ-Link Sulfo-NHS-Biotin Reagents, spacer arm length 1.35 nm; Thermo Scientific) during 45 min at ...
Inhibition of actin filament depolymerization by the Dictyostelium30,000-D actin-bundling protein
Supplier
Chen Bin et al., In The Journal of Cell Biology, 1991
... The 0.2-M imidazole eluate was dialyzed against 0.1 M KCl, 10 mM imidazole-HCl, 1 mM NaN3, pH 7.4; treated at a concentration of 0.02–0.05
Papers on NAN
Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors.
New
Urbano et al., Buenos Aires, Argentina. In J Neurochem, Feb 2016
In 5-HT2A -/- mice, NAN-190, a specific 5-HT1A antagonist, prevented the 100 μM 5-HT inhibition while blocking H-currents that prolonged inhibition during post-puff periods.
The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors.
New
Moreira et al., Belo Horizonte, Brazil. In Eur J Pharmacol, Nov 2015
Finally, peripheral administration of NAN-190 (0.1-10 μg/paw), a 5-HT1A antagonist, also prevented aripiprazole-induced antinociception.
Anti-nociceptive and anti-inflammatory activities of 4-[(1-phenyl-1H-pyrazol-4-yl) methyl] 1-piperazine carboxylic acid ethyl ester: A new piperazine derivative.
New
Costa et al., Goiânia, Brazil. In Pharmacol Biochem Behav, Oct 2015
Furthermore, pre-treatment with NAN-190 (0.6mg/kgi.p.) and PCPA (100mg/kgi.p.) antagonized the anti-nociceptive effect of LQFM-008 in both phases of the formalin test.
Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica (L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors.
New
Thakurdesai et al., Pune, India. In Chin J Nat Med, Apr 2015
The interaction of INDCA with selective 5-HT1A, 5-HT1B, and 5-HT1D receptor antagonists (NAN-190, Isamoltane hemifumarate, and BRL-15572 respectively) against NTG-induced hyperalgesia was also evaluated.
Activation of 5-HT receptors inhibits GABAergic transmission by pre-and post-synaptic mechanisms in layer II/III of the juvenile rat auditory cortex.
New
Salgado et al., Dallas, United States. In Synapse, Mar 2015
The inhibiting influence of 5-HT in the GABAergic synaptic activity was mimicked by using the selective agonists of the 5-HT1A and 5-HT2A receptors, 8(OH)-DPAT (10 µM) and DOI (10 µM), respectively; and it was prevented by their respective antagonists NAN-190 (1 µM) and ritanserin (1 μM).
Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system.
Sousa et al., Fortaleza, Brazil. In Braz J Med Biol Res, 2015
The anti-immobility effect of H. gordonii was prevented by pretreatment of mice with PCPA [an inhibitor of serotonin (5-HT) synthesis], NAN-190 (a 5-HT1A antagonist), ritanserin (a 5-HT2A/2C antagonist), ondansetron (a 5-HT3A antagonist), prazosin (an α1-adrenoceptor antagonist), SCH23390 (a D1 receptor antagonist), yohimbine (an α2-adrenoceptor antagonist), and sulpiride (a D2 receptor antagonist).
Impaired fibrinolysis in angiographically documented coronary artery disease.
Carvalho et al., Belo Horizonte, Brazil. In Adv Hematol, 2014
We measured plasma levels of PAI-1 and TAFI antigen in 123 patients with age ranging from 40 to 65 years who had been submitted to coronary angiography and assessed the association of these markers with the extent of stenosis in three groups: angiographically normal artery (NAn), mild to moderate atheromatosis (MA), and severe atheromatosis (SA).
Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system.
Sousa et al., Fortaleza, Brazil. In Braz J Med Biol Res, 2014
The anti-immobility effect of H. gordonii was prevented by pretreatment of mice with PCPA [an inhibitor of serotonin (5-HT) synthesis], NAN-190 (a 5-HT1A antagonist), ritanserin (a 5-HT2A/2C antagonist), ondansetron (a 5-HT3A antagonist), prazosin (an α1-adrenoceptor antagonist), SCH23390 (a D1 receptor antagonist), yohimbine (an α2-adrenoceptor antagonist), and sulpiride (a D2 receptor antagonist).
Effects of two serotoninergic agents on the behavioral manifestations in rats.
Mititelu-Tarţău et al., In Rev Med Chir Soc Med Nat Iasi, 2014
MATERIAL AND METHOD: The experiment was carried out on white male Wistar rats (150-200g) divided into 3 groups of 6 animals each, treated intraperitoneally with the same volume of solution as follows: Group I (Control): saline solution 0.1 ml/10 g weight; Group II (SB-269970): SB-269970 1 mg/kbw; Group III (NAN-190): NAN-190 1 mg/kbw.
Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats.
Kim et al., Seoul, South Korea. In Bmc Complement Altern Med, 2013
Further, an intrathecal injection of MDL-72222 (12 μg) completely blocked the BVA-induced anti-allodynic action, whereas NAN-190 (5-HT1A receptor antagonist, 15 μg, i.t.) or ketanserin (5-HT2A receptor antagonist, 30 μg, i.t.) did not.
Nav1.9 channel contributes to mechanical and heat pain hypersensitivity induced by subacute and chronic inflammation.
GeneRIF
Busserolles et al., Clermont-Ferrand, France. In Plos One, 2010
Results provide evidence that Nav1.9 plays a crucial role in the generation of heat and mechanical pain hypersensitivity, both in subacute and chronic inflammatory pain models.
Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice.
GeneRIF
Meert et al., Beerse, Belgium. In Behav Brain Res, 2010
The present study provides evidence for a modulatory role of Na(v)1.9 also indicate that Na(v)1.9 signaling might be involved in visceral pain.
Regulation of the spontaneous augmentation of Na(V)1.9 in mouse dorsal root ganglion neurons: effect of PKA and PKC pathways.
GeneRIF
Ogata et al., Hiroshima, Japan. In Mar Drugs, 2009
results indicate that the spontaneous augmentation of Na(V)1.9 was regulated directly by protein kinase A, and indirectly by protein kinase C
Differential expression of neuronal voltage-gated sodium channel mRNAs during the development of the rat trigeminal ganglion.
GeneRIF
Fried et al., Huddinge, Sweden. In Brain Res, 2009
trigeminal ganglion sodium channel transcripts mature in steps that are specific for each transcript in development
[Nav1.8 and Nav1.9 mRNA expression in rat trigeminal ganglion at different interval after molar extraction].
GeneRIF
Wang et al., Beijing, China. In Zhonghua Kou Qiang Yi Xue Za Zhi, 2009
The pain caused by molar extraction is related to the up-regulation of expressions of sodium channels protein Nav1.8 and Nav1.9 mRNA.
The mechanosensitive nature of TRPV channels.
Review
Heller et al., Houston, United States. In Pflugers Arch, 2005
Likewise, two Drosophila TRPV channels, NAN and IAV, have been shown to be critical for hearing by the mechanosensitive chordotonal organs located in the fly's antennae.
Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution.
Review
Waxman et al., New Haven, United States. In Mol Neurobiol, 2002
SCN11A encodes the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.9a/NaN, which is preferentially expressed in nociceptive primary sensory neurons of dorsal root ganglia (DRG) and trigeminal ganglia.
NaN/Nav1.9: a sodium channel with unique properties.
Review
Waxman et al., New Haven, United States. In Trends Neurosci, 2002
The Na(v)1.9 Na(+) channel (also known as NaN) is preferentially expressed in nociceptive neurons of the dorsal root ganglia (DRG) and trigeminal ganglia.
In vitro culture and embryo metabolism of cattle and sheep embryos - a decade of achievement.
Review
Thompson, Hamilton, New Zealand. In Anim Reprod Sci, 2000
Compounds such as ethylenediamine tetraacetic acid (EDTA), NaN(3) and 2,4-dinitrophenol have been shown to increase embryo development and quality of resulting embryos.
The molecular pathophysiology of pain: abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons.
Review
Waxman, New Haven, United States. In Pain, 1999
There is a dramatic change in sodium channel expression in DRG neurons, with down-regulation of the SNS/PN3 and NaN sodium channel genes and up-regulation of previously silent Type III sodium channel gene, following injury to the axons of these cells.
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