Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence.
Beijing, China. In Curr Opin Microbiol, Dec 2015
Among the canonical caspase-1-activating inflammasomes, the NAIP subfamily of NLR proteins serves as the receptors for bacterial flagellin and type III secretion apparatus; Pyrin indirectly senses Rho modification/inactivation by various bacterial agents; NLRP1 in mice/rats detects the protease activity of anthrax lethal toxin by serving as its substrate.
The NLRP1 inflammasomes.
Berkeley, United States. In Immunol Rev, May 2015
We conclude by discussing the unexpected differences in the mechanism of NLRP1 inflammasome activation, as compared to the activation of other inflammasomes, such as the NAIP (NLR family, apoptosis inhibitory protein)/NLRC4 inflammasomes.
The NAIP/NLRC4 inflammasomes.
United States. In Curr Opin Immunol, Feb 2015
Although the precise molecular mechanism by which most inflammasomes are activated remains a subject of considerable debate, the NAIP/NLRC4 subfamily of inflammasomes is increasingly well understood.
The NLRP3 inflammasome and stroke.
Wuhan, China. In Int J Clin Exp Med, 2014
Inflammasome pattern recognition receptors, which belong to the family of multi-meric proteins, play an important role in innate immunity, including NLRPs, NLRC, and NAIP.