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NLR family, apoptosis inhibitory protein

NAIP, Neuronal Apoptosis-Inhibitory Protein
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SmaI, PrP, CAN, HAD, XIAP
Papers on NAIP
Spinal muscular atrophy type III: Molecular genetic characterization of Turkish patients.
New
Erdem-Yurter et al., Ankara, Turkey. In Eur J Med Genet, Dec 2015
SMN2, homologue of SMN1, and Neuronal apoptosis inhibitory protein (NAIP) genes were also evaluated considering their influence on disease severity.
Downregulation of microRNA-1 and microRNA-145 contributes synergistically to the development of colon cancer.
New
Wu et al., Guangzhou, China. In Int J Mol Med, Dec 2015
Following functional analysis, we noted that three miRNAs which were significantly downregulated, miR-145, miR-451 and miR-1, shared the same target gene, [NLR family, apoptosis inhibitory protein (NAIP)], which has previously been reported to be involved in the development of colon cancer.
Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence.
Review
New
Shao et al., Beijing, China. In Curr Opin Microbiol, Dec 2015
Among the canonical caspase-1-activating inflammasomes, the NAIP subfamily of NLR proteins serves as the receptors for bacterial flagellin and type III secretion apparatus; Pyrin indirectly senses Rho modification/inactivation by various bacterial agents; NLRP1 in mice/rats detects the protease activity of anthrax lethal toxin by serving as its substrate.
Structural and biochemical basis for induced self-propagation of NLRC4.
New
Impact
Chai et al., Beijing, China. In Science, Nov 2015
Recognition of bacterial pathogens by NLR apoptosis inhibitory proteins (NAIPs) induces NLR family CARD domain-containing protein 4 (NLRC4) activation and formation of NAIP-NLRC4 inflammasomes.
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
New
Impact
Wu et al., Boston, United States. In Science, Nov 2015
We found that the PrgJ-NAIP2-NLRC4 inflammasome is assembled into multisubunit disk-like structures through a unidirectional adenosine triphosphatase polymerization, primed with a single PrgJ-activated NAIP2 per disk.
The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus.
Review
New
Shao et al., Beijing, China. In Immunol Rev, May 2015
Studies in the past 10 years have established a NAIP-NLRC4 inflammasome, in which NAIPs are cytosolic receptors for bacterial flagellin and T3SS rod/needle proteins, while NLRC4 acts as an adapter for caspase-1 activation.
The NLRP1 inflammasomes.
Review
New
Vance et al., Berkeley, United States. In Immunol Rev, May 2015
We conclude by discussing the unexpected differences in the mechanism of NLRP1 inflammasome activation, as compared to the activation of other inflammasomes, such as the NAIP (NLR family, apoptosis inhibitory protein)/NLRC4 inflammasomes.
The NAIP/NLRC4 inflammasomes.
Review
New
Vance, United States. In Curr Opin Immunol, Feb 2015
Although the precise molecular mechanism by which most inflammasomes are activated remains a subject of considerable debate, the NAIP/NLRC4 subfamily of inflammasomes is increasingly well understood.
Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele.
Marini et al., Messina, Italy. In Biomed Res Int, 2014
Neuronal apoptosis inhibitory protein (NAIP) and survivin might play an important role in testicular function.
The NLRP3 inflammasome and stroke.
Review
Liu et al., Wuhan, China. In Int J Clin Exp Med, 2014
Inflammasome pattern recognition receptors, which belong to the family of multi-meric proteins, play an important role in innate immunity, including NLRPs, NLRC, and NAIP.
Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy.
Royuela et al., Madrid, Spain. In Bmc Cancer, 2014
METHODS: Protein expression of caspases (procaspase-8, cleaved caspase-8, procaspase-3, cleaved caspase-3, caspase-7 and procaspase-9) and IAPs (cIAP1/2, cIAP2, NAIP, Survivin and XIAP) was analyzed by immunohistochemistry in radical prostatectomy samples from 84 prostate cancer patients.
Mechanisms of NOD-like receptor-associated inflammasome activation.
Review
Impact
Ting et al., Chapel Hill, United States. In Immunity, 2013
This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.
Clinical and Genetic Study of Algerian Patients with Spinal Muscular Atrophy.
Hamri et al., Constantine, Algeria. In J Neurodegener Dis, 2012
Another candidate gene in SMA is the neuronal apoptosis inhibitory protein (NAIP) gene; it shows homozygous deletions in 45-67% of type I and 20-42% of type II/type III patients.
Correlation of SMN2, NAIP, p44, H4F5 and Occludin genes copy number with spinal muscular atrophy phenotype in Tunisian patients.
GeneRIF
Gribaa et al., Sousse, Tunisia. In Eur J Paediatr Neurol, 2012
There is a close relationship between SMN2, NAIP and H4F5 gene copy number and spinal muscular atrophy disease severity
Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection.
GeneRIF
Quintana-Murci et al., Paris, France. In Hum Immunol, 2012
NAIPFull gene duplication might have been evolutionary maintained, or even selected for, because it may confer an advantage to the host against flagellated bacteria
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.
Impact
Vance et al., Berkeley, United States. In Nature, 2011
In particular, we found that activation of endogenous NLRC4 by bacterial PrgJ requires NAIP2, a previously uncharacterized member of the NAIP gene family, whereas NAIP5 and NAIP6 activate NLRC4 specifically in response to bacterial flagellin.
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
Impact
Shao et al., Beijing, China. In Nature, 2011
The related NAIP2 functioned analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.
Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP.
GeneRIF
Ghahremani et al., Tehrān, Iran. In Biochem Biophys Res Commun, 2011
NOD domain is essential for effective inhibition of procaspase-9 and procaspase-3 cleavage by the NAIP protein in apoptosis.
Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer.
GeneRIF
Sadar et al., Vancouver, Canada. In Cancer Lett, 2010
Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration
Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9.
GeneRIF
Mackenzie et al., Tehrān, Iran. In Int J Biochem Cell Biol, 2010
an inhibitor of procaspase-9 preventing apoptosis at the initiation stage
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