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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD244 molecule, natural killer cell receptor 2B4

Nail, 2B4
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, CD48, HAD, V1a
Papers on Nail
The role of the proximal cysteine hydrogen bonding interaction in cytochrome P450 2B4 studied by cryoreduction/EPR/ENDOR spectroscopy.
Waskell et al., In Biochemistry, Feb 2016
UNASSIGNED: Crystallographic studies have shown that the F429H mutation of cytochrome P450 2B4 introduces an H-bond between His 429 and the proximal thiolate ligand, Cys 436, without altering the protein fold but sharply decreases the enzymatic activity and stabilizes the oxyferrous P450 2B4 complex.
Association of Nail Dystrophy With Accrued Damage and Capillaroscopic Abnormalities in Systemic Lupus Erythematosus.
Silveira et al., Mexico. In J Clin Rheumatol, Jan 2016
BACKGROUND: There are some nail abnormalities described in systemic lupus erythematosus (SLE).
ME1111, a New Antifungal Agent for Topical Treatment of Onychomycosis: Characterization of Antifungal Activity and Nail Penetration.
Maebashi et al., Yokohama, Japan. In Antimicrob Agents Chemother, Jan 2016
UNASSIGNED: Fungal nail infection (onychomycosis) is a prevalent disease in many areas of the world with a high incidence approaching 23%.
Comparison of Hematologic and Biochemical Test Results in Blood Samples Obtained by Jugular Venipuncture Versus Nail Clip in Moluccan Cockatoos (Cacatua moluccensis).
Lane et al., In J Avian Med Surg, Dec 2015
Samples are sometimes collected by toe nail clip, but concerns to avoid drawing blood from the nail include pain after nail clips for blood collection, potential differences in complete blood count (CBC) results, and potential contamination with uric acid values.
From plate to nail: a case-report of proximal humerus non-union.
Salini et al., Pescara, Italy. In Injury, Dec 2015
Due to implant failure, twelve weeks later the fixation was revised to Titanium Cannulated Humeral Nail.
Nail toxicities induced by systemic anticancer treatments.
Baran et al., Villejuif, France. In Lancet Oncol, Apr 2015
However, some nail toxicities can cause pain and functional impairment and thus substantially affect a patient's quality of life, especially if they are given taxanes or EGFR inhibitors.
New insights into T-cell cosignaling in allograft rejection and survival.
Ford et al., Atlanta, United States. In Curr Opin Organ Transplant, Feb 2015
Finally, several novel cosignaling pathways have been demonstrated to be important to graft-specific T cells, including CD160, signaling lymphocytic activation molecule family member 2B4, T-cell Ig mucin 4, and the Notch receptor.
Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases.
Jeong et al., Chicago, United States. In Sci Rep, 2014
Inhibition kinetic profiles of a panel of UGT enzymes (UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B4, 2B7, 2B15, and 2B17) by four TKIs (axitinib, imatinib, lapatinib and vandetanib) were characterized by using hepatic microsomes and recombinant proteins.
Mast cells' integrated actions with eosinophils and fibroblasts in allergic inflammation: implications for therapy.
Levi-Schaffer et al., Jerusalem, Israel. In Adv Immunol, 2014
One of the salient features of the AEU is the CD48/2B4 receptor/ligand binding complex.
Transcriptional regulation of human UDP-glucuronosyltransferase genes.
Mackenzie et al., Australia. In Drug Metab Rev, 2014
Glucuronidation is primarily catalyzed by the UDP-glucuronosyltransferase (UGT) 1A and two subfamilies, including nine functional UGT1A enzymes (1A1, 1A3-1A10) and 10 functional UGT2 enzymes (2A1, 2A2, 2A3, 2B4, 2B7, 2B10, 2B11, 2B15, 2B17 and 2B28).
When all you have is a dermatoscope- start looking at the nails.
Brehmer et al., Göttingen, Germany. In Dermatol Pract Concept, 2014
Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists.
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.
Schwartzberg et al., Bethesda, United States. In Immunity, 2012
In the absence of SAP, signaling through the SLAM family members Ly108 and 2B4 resulted in increased recruitment of the SHP-1 phosphatase, associated with altered SHP-1 localization and decreased activation of Src kinases at the synapse.
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence.
Wei et al., Hefei, China. In Plos Pathog, 2011
TGF-beta1 may reduce the expression of NKG2D/DAP10 and 2B4/SAPin patients with hepatitis B.
2B4 (CD244) is involved in eosinophil adhesion and chemotaxis, and its surface expression is increased in allergic rhinitis after challenge.
Louis et al., Liège, Belgium. In Int J Immunopathol Pharmacol, 2011
These results identify a novel role for 2B4 molecules in eosinophil functional migratory response and may point to a novel tyrosine kinase-mediated ligation between CCR3 receptor and 2B4 co-receptor in eosinophil chemotaxis.
Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.
Ahmed et al., Atlanta, United States. In Immunity, 2011
This loss of memory cells was due to a block in sustaining cell proliferation, selective regulation by the inhibitory receptor 2B4, and increased reliance on CD4(+) T cell help.
Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity.
Sharpe et al., Boston, United States. In J Immunol, 2011
Slamf4 has a natural killer (NK) cell-independent negative regulatory function in vivo and can contribute to tolerance to chromatin in murine models of systemic lupus erythematosus.
Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells.
Wedemeyer et al., Hannover, Germany. In Plos Pathog, 2011
2B4 is an important molecule within the network of costimulatory/inhibitory receptors regulating CD8+ T cell function in acute and chronic hepatitis C and 2B4 expression levels could also be a marker of CD8+ T cell dysfunction.
SLAM family receptors and SAP adaptors in immunity.
Schwartzberg et al., Bethesda, United States. In Annu Rev Immunol, 2010
The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) syndrome, a rare genetic disorder characterized by abnormal responses to Epstein-Barr virus infection, lymphoproliferative syndromes, and dysgammaglobulinemia. SAP consists almost entirely of a single SH2 protein domain that interacts with the cytoplasmic tail of SLAM and related receptors, including 2B4, Ly108, CD84, Ly9, and potentially CRACC.
Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase.
Long et al., Rockville, United States. In Immunity, 2010
Natural killer (NK) cell cytotoxicity toward target cells depends on synergistic coactivation by NK cell receptors such as NKG2D and 2B4.
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