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NEDD8 activating enzyme E1 subunit 1

NaeI, APP-BP1, proto-oncogene protein DEK
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, NEDD8, APP, 4E-BP1, Uba3
Papers using NaeI antibodies
Analysis of inducers of the E.coli lac repressor system in mammalian cells and whole animals.
Supplier
Milstone David, In PLoS ONE, 1990
... ) was excised by BglII digest and subcloned after fill-in and NotI digest into partially NaeI, EagI digested VavP21/45 transgenic vector ...
Papers on NaeI
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex.
Grossman et al., Tel Aviv-Yafo, Israel. In Cell Div, 2014
Deneddylation rate was tested either simultaneous to neddylation or after termination of neddylation by using an ATP depleting reaction or by directly inhibiting the neddylation activation enzyme named APP-BP1/UBA3 by its specific inhibitor MLN-4924.
Cycle on Wheels: Is APP Key to the AppBp1 Pathway?
Mrak et al., United States. In Austin Alzheimers Parkinsons Dis, 2013
Here we analyze the existing data in literature and hypothesize that the physiological function of the Amyloid Precursor Protein (APP) is activating the AppBp1 pathway and this function is gradually lost during the progression of AD pathogenesis.
Physiological genomics analysis for Alzheimer's disease.
Wiwanitkit, Bangkok, Thailand. In Ann Indian Acad Neurol, 2013
Considering the results, the HADH2 gene on chromosome X, APBA1 gene on chromosome 9, AGER gene on chromosome 6, GSK3B gene on chromosome 3, CDKHR1 gene on chromosome 17, APPBP1 gene on chromosome 16, APBA2 gene on chromosome 15, GAL gene on chromosome 11, and APLP2 gene on chromosome 11 have the highest physiogenomics score (9.26) while the CASP3 gene on chromosome 4 and the SNCA gene on chromosome 4 have the lowest physiogenomics score (7.44).
Neddylation dysfunction in Alzheimer's disease.
Review
Liu et al., Little Rock, United States. In J Cell Mol Med, 2012
Central to the neddylation pathway is the amyloid precursor protein (APP)-binding protein APP-BP1, which together with Uba3, plays an analogous role to the ubiquitin-activating enzyme E1 in nedd8 activation.
The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation.
Jung et al., France. In Int J Oncol, 2012
We have previously shown that HPV-related oropharyngeal carcinomas express decreased levels of the NEDD8-activating enzyme 1/amyloid β precursor protein-binding protein 1 (NAE1/APP-BP1) gene.
E2-binding surface on Uba3 β-grasp domain undergoes a conformational transition.
Haas et al., Muğla, Turkey. In Proteins, 2012
The activating enzyme for neural-precursor-cell-expressed developmentally downregulated 8 (NEDD8) is a heterodimer composed of APPBP1 and Uba3 subunits.
Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells.
GeneRIF
Kim et al., Seoul, South Korea. In Neuroreport, 2012
our results suggest that APP-BP1 modulates neuronal differentiation by altering gene expression profiles in fetal neural stem cells
A metal-based inhibitor of NEDD8-activating enzyme.
Ma et al., Aomen, Macao. In Plos One, 2011
Molecular modeling analysis suggested that the overall binding mode of 1 within the binding pocket of the APPBP1/UBA3 heterodimer resembled that for MLN4924.
Identification and application of NEDD8 E1 inhibitors.
Brownell et al., Cambridge, United States. In Methods Mol Biol, 2011
The NEDD8 conjugation pathway is initiated by the NEDD8 E1, also known as NEDD8 activating enzyme (NAE) or APPBP1/UBA3 (Gong, Yeh.
Focal transient ischemia increases APP-BP1 expression in neural progenitor cells.
GeneRIF
Kim et al., Seoul, South Korea. In Neuroreport, 2011
The upregulation of APP-BP1 expression in neural progenitor cells after focal transient ischemia suggests that this protein contributes to the neurogenesis induced by transient ischemia and reperfusion
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
Yanagisawa et al., Tsukuba, Japan. In Plos One, 2010
Trip12 is a HECT-type E3 ubiquitin ligase that ubiquitinates ARF and APP-BP1.
Cruciform structures are a common DNA feature important for regulating biological processes.
Review
Arrowsmith et al., Brno, Czech Republic. In Bmc Mol Biol, 2010
They also have been implicated in the evolution and development of diseases including cancer, Werner's syndrome and others.Cruciform structures are targets for many architectural and regulatory proteins, such as histones H1 and H5, topoisomerase IIβ, HMG proteins, HU, p53, the proto-oncogene protein DEK and others.
Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma.
GeneRIF
Wasylyk et al., Strasbourg, France. In Int J Cancer, 2010
APP-BP1 displayed decreased expression levels in HPV-positive head and neck squamous cell carcinoma
Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells.
GeneRIF
Kim et al., Seoul, South Korea. In Plos One, 2009
APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells
TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.
GeneRIF
Yoon et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2008
APP-BP1 is degraded by ubiquitin-dependent proteolysis.
Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Impact
Schulman et al., Memphis, United States. In Nature, 2007
Here we report the structural analysis of a trapped UBL activation complex for the human NEDD8 pathway, containing NEDD8's heterodimeric E1 (APPBP1-UBA3), two NEDD8s (one thioester-linked to E1, one noncovalently associated for adenylation), a catalytically inactive E2 (Ubc12), and MgATP.
APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin.
Review
Chen, United States. In Apoptosis, 2004
This mini-review focuses on how the amyloid precursor protein (APP) plays a central role in AD and Down syndrome as the regulator of the APP-BP1/hUba3 activated neddylation pathway.
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.
Impact
GeneRIF
Schulman et al., Memphis, United States. In Nature, 2003
structure and mutational analysis of human APPBP1-UBA3, the heterodimeric E1 enzyme for NEDD8
Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein.
Review
Zambrano et al., Napoli, Italy. In Febs Lett, 1998
The other proteins interacting with the cytosolic domain of APP are the G(o) heterotrimeric protein, APP-BP1 and X11.
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