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POR P450 (cytochrome) oxidoreductase

NADPH-cytochrome P-450 reductase
Top mentioned proteins: ACID, HAD, CAN, demethylase, Presenilin-1
Papers on NADPH-cytochrome P-450 reductase
[Generation of superoxide anion-radical in the liver monooxygenase system of preliminary radiation-exposed tumor-bearing rats].
Ketsa et al., In Ukr Biokhim Zh (1999), 2012
It is shown that the increased NADPH-cytochrome P-450 reductase activity is accompanied with the intensification of superoxide anion-radical generation in liver microsomal fraction of preliminary radiation-exposed rats.
An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells.
Lee et al., South Korea. In Exp Mol Med, 2008
In the cytoplasmic fraction, truncated CYP3A4 showed catalytic activity when reconstituted with NADPH-cytochrome P-450 reductase and cytochrome b5.
VEGF-enhanced proliferation under hypoxia by an autocrine mechanism in human vascular smooth muscle cells.
Sato et al., Kyoto, Japan. In J Atheroscler Thromb, 2008
A neutralizing antibody against NADPH-cytochrome P-450 reductase (NPR), which contributes to the stabilization of HIF-1alpha, also attenuated hypoxia-stimulated proliferation.
Phenomenon of activation of cytochrome P450 by nonionic detergents.
Magretova et al., Semënov, Russia. In Biosci Rep, 2006
The stimulating effect proved to be similar in reconstituted monooxygenase systems containing (a) cytochrome P450 2B4 and NADPH-cytochrome P-450 reductase and (b) cytochrome 2B4 and organic hydroperoxides.
Profile of territrem metabolism and cytochrome P-450 3A expression in liver microsomes from Wistar rats of both genders as a function of age.
Edwards et al., Taipei, Taiwan. In J Toxicol Environ Health A, 2005
The liver microsomal cytochrome P-450 content, NADPH-cytochrome P-450 reductase activity, and CYP3A1 and CYP3A2 protein and mRNA levels were also analyzed.
Activity of NADPH-cytochrome P-450 reductase of the human heart, liver and lungs in the presence of (-)-epigallocatechin gallate, quercetin and resveratrol: an in vitro study.
Murias et al., Lublin, Poland. In Basic Clin Pharmacol Toxicol, 2005
NADPH-cytochrome P-450 reductase (P-450 reductase) plays a crucial role in the metabolism of many endogenic compounds and xenobiotics detoxication.
NADPH-cytochrome P-450 reductase is involved in flunitrazepam reductive metabolism in Hep G2 and Hep 3B cells.
Lu et al., Taipei, Taiwan. In J Toxicol Environ Health A, 2004
In this study, the involvement of NADPH-cytochrome P-450 reductase in the conversion of FNTZ to 7A FNTZ was investigated in two human hepatoma cell lines, human lymphoblast microsomes specifically expressing human NADPH-cytochrome P-450 reductase and purified recombinant human HADPH-cytochrome P-450 reductase.
High-level expression of porcine liver cytochrome P-450 reductase catalytic domain in Escherichia coli by modulating the predicted local secondary structure of mRNA.
Iyanagi et al., Himeji, Japan. In J Biochem, 2003
A direct expression system for the solubilized catalytic domains of NADPH-cytochrome P-450 reductase (sCPR) from rat (RsCPR) and porcine (PsCPR) in Escherichia coli cells was constructed using the expression plasmid pCWori(+).
Detection of heme oxygenase activity by measurement of CO.
Stevenson et al., Stanford, United States. In Curr Protoc Toxicol, 2001
Heme oxygenase (HO) is the first and rate-limiting step in degradation of heme, and in the presence of NADPH-cytochrome P-450 reductase it produces equimolar amounts of biliverdin and CO.
Phospholipase A(2)s and lipid peroxidation.
Review
Schewe et al., Berlin, Germany. In Biochim Biophys Acta, 2000
Lipid peroxidation of membrane phospholipids can proceed both enzymatically via the mammalian 15-lipoxygenase-1 or the NADPH-cytochrome P-450 reductase system and non-enzymatically.
Some aspects of the role of cytochrome P-450 isozymes in the N-oxidative transformation of secondary and tertiary amine compounds.
Review
Lehnerer et al., München, Germany. In J Biochem Toxicol, 1995
Indirect evidence of the participation of cytochrome P-450 (P-450) in the microsomal N-oxygenation of secondary and tertiary nitrogen functions is presented by studies employing diagnostic modifiers of the hemoprotein system as well as antibodies directed toward the diverse P-450 isoforms and NADPH-cytochrome P-450 reductase.
[Induced modification of liver NADPH-cytochrome P-450 activity and II microsomal electron transport chain as a function of age in rats].
Review
Plewka et al., Laizhou, China. In Postepy Hig Med Dosw, 1993
In this paper we showed age effect on NADPH-cytochrome P-450 reductase activity, cytochrome b5 and NADH-cytochrome b5 reductase from rat liver.
Morphometry and immunocytochemistry.
Review
Heitz et al., In Anal Quant Cytol Histol, 1987
Immunoenzyme cytochemically stained secretions can also be studied morphometrically, and microdensitometry and microfluorometry can also be used to quantify immunocytochemical reactions, as is shown in the analysis of the intralobular distribution of NADPH-cytochrome P-450 reductase in the rat liver.
Quantitative studies of the metabolism of furazolidone by rat liver microsomes.
van Bladeren et al., Wageningen, Netherlands. In Toxicol In Vitro, 1986
Cytochrome P-450 is not involved in the conversion of furazolidone, which was converted by rat liver microsomes to products identical to those obtained upon incubation with purified NADPH-cytochrome P-450 reductase, which is a microsomal reductase.
On the possible relationship of cytochrome P-450 to alcohol metabolism: fundamental aspects of the microsomal hydroxylation system, including properties and interactions of the components.
Review
French et al., In Adv Exp Med Biol, 1979
Additional components are NADPH-cytochrome P-450 reductase, which binds to the cytochrome to form a tight 1:1 complex, phosphatidylcholine, and cytochrome b5, the role of which is still not clear.
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