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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier family 13

NaDC3, SDCT2, hNaDC3, SLC13A3
Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, CAN, CIs, POLYMERASE
Papers on NaDC3
NaDC3 Induces Premature Cellular Senescence by Promoting Transport of Krebs Cycle Intermediates, Increasing NADH, and Exacerbating Oxidative Damage.
New
Chen et al., Beijing, China. In J Gerontol A Biol Sci Med Sci, Jan 2016
High-affinity sodium-dependent dicarboxylate cotransporter 3 (NaDC3) is a key metabolism-regulating membrane protein responsible for transport of Krebs cycle intermediates.
Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality.
New
Suhre et al., München, Germany. In Plos Genet, Sep 2015
We identified and replicated 22 loci with significant associations with urinary traits, 15 of which are new (HIBCH, CPS1, AGXT, XYLB, TKT, ETNPPL, SLC6A19, DMGDH, SLC36A2, GLDC, SLC6A13, ACSM3, SLC5A11, PNMT, SLC13A3).
Structure-Based Identification of Inhibitors for the SLC13 Family of Na(+)/Dicarboxylate Cotransporters.
New
Schlessinger et al., New York City, United States. In Biochemistry, Sep 2015
We previously characterized key structural determinants of substrate and cation binding for the human NaDC3/SLC13A3 transporter using a homology model.
A renal-like organic anion transport system in the ciliary epithelium of the bovine and human eye.
New
Pelis et al., Halifax, Canada. In Mol Pharmacol, Apr 2015
mRNA (RT-PCR) and protein (immunoblotting) for OAT1, OAT3, NaDC3, and MRP4 were detected in extracts of the human ciliary body from several donors.
Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency.
Burckhardt et al., Göttingen, Germany. In Am J Physiol Renal Physiol, 2015
Organic anion-transporting polypeptides (OATPs) as well as organic anion transporters (OATs) working in cooperation with sodium dicarboxylate cotransporter 3 (NaDC3) accept a wide variety of structurally unrelated drugs.
Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria.
Orynbayeva et al., Philadelphia, United States. In Am J Cancer Res, 2014
Using specific inhibitors, it was demonstrated that succinate is transported in cancer cells by the mechanism of plasma membrane Na(+)-dependent dycarboxylic acid transporter NaDC3 (SLC13A3 gene).
Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3.
Pajor et al., San Diego, United States. In J Biol Chem, 2014
The human Na(+)/dicarboxylate cotransporter NaDC3 (SLC13A3) is found in various tissues, including the kidney, liver, and brain.
Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family.
Review
Pajor, San Diego, United States. In Pflugers Arch, 2014
This review will focus on the di- and tricarboxylate transporters: NaDC1 (SLC13A2), NaDC3 (SLC13A3), and NaCT (SLC13A5).
An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.
Koizumi et al., Kyoto, Japan. In J Occup Health, 2013
The GWAS yielded a genome-wide significant association with CKDu for a single nucleotide polymorphism (SNP; rs6066043; p=5.23 × 10(-9) in quantitative trait locus analysis; p=3.73 × 10(-9) in dichotomous analysis) in SLC13A3 (sodium-dependent dicarboxylate transporter member 3).
N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.
Jaworski et al., Burlington, United States. In J Biol Chem, 2013
Although the NAA dicarboxylate transporter NaDC3 is primarily thought to be expressed by astrocytes, all cell lines expressed NaDC3 and, thus, are capable of NAA up-take.
SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate transporters.
Review
Markovich et al., Québec, Canada. In Mol Aspects Med, 2013
While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and α-ketoglutarate.
Glutathione is a low-affinity substrate of the human sodium-dependent dicarboxylate transporter.
Burckhardt et al., Göttingen, Germany. In Nephron Physiol, 2012
Due to the dicarboxylate-like structure, we postulated that GSH uptake across the basolateral membrane is mediated by the sodium-dependent dicarboxylate transporter 3 (NaDC3).
Sodium-sulfate/carboxylate cotransporters (SLC13).
Review
Markovich, Brisbane, Australia. In Curr Top Membr, 2011
Members of this gene family (in ascending order) are: SLC13A1 (NaS1), SLC13A2 (NaC1), SLC13A3 (NaC3), SLC13A4 (NaS2) and SLC13A5 (NaC2).
Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3.
GeneRIF
Burckhardt et al., Göttingen, Germany. In Am J Physiol Renal Physiol, 2011
The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3
PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.
GeneRIF
Walter et al., Edmonton, Canada. In Invest Ophthalmol Vis Sci, 2011
The results indicate that SLC13A3 is a direct downstream target of PITX2 transcriptional regulation and that levels of PITX2 and SLC13A3 modulate responses to oxidative stress in ocular cells.
High-affinity Na(+)-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1.
GeneRIF
Chen et al., Beijing, China. In Mech Ageing Dev, 2010
NaDC3 promotes cellular senescence probably by inhibiting NAD(+)-dependent SIRT1.
3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3.
GeneRIF
Mühlhausen et al., Hamburg, Germany. In J Mol Med (berl), 2007
demonstrate the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations
Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3.
GeneRIF
Shi et al., Beijing, China. In J Cell Physiol, 2006
We provide direct evidence of the localization of NaDC3 at the basolateral membrane of human renal proximal tubule cells and identify a di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain of NaDC3.
Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters.
Review
Pajor, Galveston, United States. In Pflugers Arch, 2006
The other members of the family (NaDC1, NaDC3, and NaCT) are transporters for di- and tri-carboxylates including succinate, citrate and alpha-ketoglutarate.
Role of glutathione transport processes in kidney function.
Review
Lash, Detroit, United States. In Toxicol Appl Pharmacol, 2005
Data suggest that the organic anion transporters OAT1 and OAT3 and the sodium-dicarboxylate 2 exchanger (SDCT2 or NaDC3) mediate uptake across the basolateral plasma membrane (BLM) and that the organic anion transporting polypeptide OATP1 and at least one of the multidrug resistance proteins mediate efflux across the brush-border plasma membrane (BBM).
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