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NAD synthetase 1

NAD synthetase, glutamine-dependent NAD synthetase, glutamine-dependent NAD(+) synthetase
Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: ACID, Bex, STEP, HAD, CAN
Papers on NAD synthetase
Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of NAD synthetase from methicillin-resistant Staphylococcus aureus.
Srivastava et al., Pune, India. In Acta Crystallogr Sect F Struct Biol Commun, Jun 2015
NAD synthetase catalyzes the last step in the biosynthesis of nicotinamide adenine dinucleotide, making it a crucial intermediate enzyme linked to the biosynthesis of several amino acids, purine and pyrimidine nucleotides, coenzymes and antibiotics.
Screening for salt-responsive proteins in two contrasting alfalfa cultivars using a comparative proteome approach.
Lee et al., Chinju, South Korea. In Plant Physiol Biochem, Apr 2015
Peroxidase, protein disulfide-isomerase, NAD synthetase, and isoflavone reductase were up-regulated significantly only in NM-801 in all salt concentrations.
Vitamin d binding protein gene polymorphism as a risk factor for vitamin d deficiency in thais.
Ongphiphadhanakul et al., Bangkok, Thailand. In Endocr Pract, Mar 2015
To date, at least 3 candidate genes, vitamin D binding protein (VDBP) gene (GC), 25-hydroxylase (CYP2R1), and 7-dehydrocholesterol reductase/NAD synthetase 1 (DHCR7/NADSYN1), have been associated with serum 25-hydroxyvitamin D (25[OH]D) levels, but their influences on the prevalence of vitamin D deficiency in relation to other known risk factors have not been clearly defined.
Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome.
Shyy et al., Riverside, United States. In Bmc Syst Biol, 2014
Following initial validation, pathways that include NAD synthetase 1 (NADSYN1) and protein kinase B (AKT2) were hypothesized and experimentally tested to provide a mechanistic basis for AMPK regulation of cell migration and maintenance of cellular NAD(+) concentrations during catabolic processes.
Enhancement of bioelectricity generation by cofactor manipulation in microbial fuel cell.
Zheng et al., Nanjing, China. In Biosens Bioelectron, 2014
By overexpression of nadE (NAD synthetase gene), the availability of the intracellular cofactor pool (NAD(H/(+))) significantly increased, and delivered approximately three times higher power output than the original strain (increased from 10.86 μW/cm(2) to 40.13 μW/cm(2)).
A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness).
Hamsten et al., Stockholm, Sweden. In Diabetologia, 2014
RESULTS: SNPs in the genes encoding vitamin D binding protein (GC; rs2282679 and rs7041) and 7-dehydrocholesterol reductase/NAD synthetase-1 (DHCR7; rs12785878 and rs3829251) were negatively associated with 25(OH)D levels.
Metabolic profiling of alternative NAD biosynthetic routes in mouse tissues.
Orsomando et al., Ancona, Italy. In Plos One, 2013
Here we focused on the indispensable enzymes gating these two routes, i.e. nicotinamide mononucleotide adenylyltransferase (NMNAT), which in mammals comprises three distinct isozymes, and NAD synthetase (NADS).
Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria.
Osterman et al., In Mbio, 2013
NaMN adenylyltransferase (NadD) and NAD synthetase (NadE), the key enzymes of NAD biosynthesis, were selected as promising candidate drug targets for M. tuberculosis.
Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.
Osterman et al., Los Angeles, United States. In J Bacteriol, 2013
Finally, the redundancy of functional upstream salvage pathways in GAS species narrows the choice of potential drug targets to the two indispensable downstream enzymes of NAD synthesis, nicotinate adenylyltransferase (NadD family) and NAD synthetase (NadE family).
Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D status and metabolic profile in Non-diabetic adults.
Ducros et al., France. In Bmc Endocr Disord, 2012
BACKGROUND: Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN1) of 25 hydroxyvitamin D (25(OH)D) in non-diabetic individuals.
Associations between polymorphisms related to calcium metabolism and human height: the Tromsø Study.
Grimnes et al., Tromsø, Norway. In Ann Hum Genet, 2012
several SNPs related to calcium metabolism are associated with height, in particular rs3829251 at the DHCR7/NADSYN1 gene.
Glutamine versus ammonia utilization in the NAD synthetase family.
Sorci et al., Los Angeles, United States. In Plos One, 2011
The last step of NAD synthesis is the ATP-dependent amidation of deamido-NAD by NAD synthetase (NADS).
[Microbial NAD synthetase and its inhibitors--a review].
Xie et al., Chongqing, China. In Wei Sheng Wu Xue Bao, 2011
Nicotinamide-adenine dinucleotide (phosphate) (NAD(P)) metabolism involves many fundamental cellular events, such as energy metabolism, maintenance of redox homeostasis and regulation of cell longevity.
Comparative genomics of NAD(P) biosynthesis and novel antibiotic drug targets.
Xie et al., Chongqing, China. In J Cell Physiol, 2011
Three enzymes pivotal to the key reactions of NAD(P) biosynthesis are shared by almost all organisms, that is, NMN/NaMN adenylyltransferase (NMN/NaMNAT), NAD synthetase (NADS), and NAD kinase (NADK).
NAD(P) biosynthesis enzymes as potential targets for selective drug design.
Ruggieri et al., Ancona, Italy. In Curr Med Chem, 2008
Key reactions for NAD(P) biosynthesis in all organisms, common to both de novo and salvage routes, are catalyzed by NMN/NaMN adenylyltransferase (NMNAT), NAD synthetase (NADS), and NAD kinase (NADK).
Asthma and oxidant stress: nutritional, environmental, and genetic risk factors.
Greene, Boston, United States. In J Am Coll Nutr, 1995
Environmental lead exposure depresses the activities of a several enzyme systems that influence cellular reducing capacity (glucose-6-phosphate dehydrogenase, NAD synthetase, glutathione peroxidase, superoxide dismutase, catalase) and consequently may increase asthma risk.
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