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NGFI-A binding protein 2

NAB2, Mader, Nab2p
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Egr-1, CAN, STAT6, HAD, AGE
Papers on NAB2
'Papillary' solitary fibrous tumor/hemangiopericytoma with nuclear STAT6 expression and NAB2-STAT6 fusion.
New
Sasaki et al., Saitama, Japan. In Brain Tumor Pathol, Feb 2016
By reverse transcription-polymerase chain reaction (RT-PCR), an NAB2-STAT6 fusion gene, NAB2 exon6-STAT6 exon17, was detected, establishing a definite diagnosis of SFT/HPC.
Yersinia ruckeri lipopolysaccharide is necessary and sufficient for eliciting a protective immune response in rainbow trout (Oncorhynchus mykiss, Walbaum).
New
LaPatra et al., United States. In Fish Shellfish Immunol, Feb 2016
Mutation of the nab2 gene, a nonulosonic acid biosynthesis gene (nab gene), resulted in production of severely truncated forms of LPS.
Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining.
New
Palazzo et al., Catania, Italy. In Pathol Res Pract, Jan 2016
As STAT6 nuclear immunoexpression is the result of the inv12(q13q13)-derived NAB2-STAT6 fusion, which characterizes SFT, we analyzed immunohistochemically our case with a commercially available anti-STAT6 antibody.
The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors.
New
Chen et al., Taiwan. In Cancer Med, Jan 2016
UNASSIGNED: NAB2-STAT6 gene fusion drives STAT6 nuclear expression and is the pathognomonic hallmark of solitary fibrous tumors (SFTs).
Ocular adnexal (orbital) solitary fibrous tumor: nuclear STAT6 expression and literature review.
Review
New
Hamedani et al., Lausanne, Switzerland. In Graefes Arch Clin Exp Ophthalmol, Sep 2015
To assess the presence of NAB2-STAT6 genes fusion in OA solitary fibrous tumor detected by nuclear overexpression of STAT6.
Immunohistochemical detection of STAT6, CD34, CD99 and BCL-2 for diagnosing solitary fibrous tumors/hemangiopericytomas.
Jin et al., Shenyang, China. In Int J Clin Exp Pathol, 2014
Recently, NGFI-A binding protein 2 (NAB2)-signal transducer and the activator of transcription 6 (STAT6) fusion gene were discovered as a hallmark of SFTs/HPCs by using whole-exome, and transcriptome sequencing; consequently, the fusion gene can be rapidly detected by STAT6 immunohistochemistry.
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
Impact
Lindquist et al., Cambridge, United States. In Science, 2013
A small molecule identified in a yeast screen (NAB2), and the ubiquitin ligase Nedd4 it affects, reversed pathologic phenotypes in these neurons.
[The new WHO classification and recent results in soft tissue tumor pathology].
Review
Petersen, Jena, Germany. In Pathologe, 2013
At present there is considerable progress in tumor pathology illustrated by the fact that important new findings have been published after completion of the classification, such as those related to the identification of the recurrent NAB2-STAT6 gene fusion in solitary fibrous tumors and the detection of frequent mutations in the promoter of the hTERT gene in malignant melanoma.
Novel pathways and molecular targets for the treatment of sarcoma.
Review
Van Tine et al., Saint Louis, United States. In Curr Oncol Rep, 2013
Recently identified novel druggable targets include the MDM2 amplifications in well-differentiated and dedifferentiated liposarcomas, the new translocation NAB2:STAT6 of solitary fibrous tumors, the angiopoeitin-TIE2 pathway in angiosarcoma, the suppression of Mcl1 in X:18/synovial sarcomas, the mTOR pathway in malignant peripheral nerve sheath tumors, CDK4 in alveolar rhabdomyosarcoma, cMET regulation in alveolar soft parts sarcoma, the metabolic abnormalities in wild-type/SHD GIST, and the lack of argininosuccinate synthetase 1 expression seen in most sarcomas.
Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing.
Impact
Chinnaiyan et al., Ann Arbor, United States. In Nat Genet, 2013
A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 was detected.
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.
Impact
Meyerson et al., Boston, United States. In Nat Genet, 2013
Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs.
Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins.
GeneRIF
Jensen et al., Århus, Denmark. In Mol Cell, 2012
nuclear mRNP surveillance step involves targeting of Rrp6p by Nab2p-bound pA-tailed RNPs and that pre-mRNA abundance is regulated at this level
Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export.
GeneRIF
Stewart et al., Cambridge, United Kingdom. In Structure, 2012
the solution structure of Nab2 ZnF5-7 and their interaction with polyadenosine-RNA
Regulation of p130(Cas)/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2.
GeneRIF
Kirsch et al., Boston, United States. In Neoplasia, 2012
p130Cas signaling induces the expression of EGR1 and NAB2
Nab2 functions in the metabolism of RNA driven by polymerases II and III.
GeneRIF
Aguilera et al., Sevilla, Spain. In Mol Biol Cell, 2011
Nab2 function is a central player in the general and coordinated control of gene expression from transcription to translation.
Recognition of polyadenosine RNA by the zinc finger domain of nuclear poly(A) RNA-binding protein 2 (Nab2) is required for correct mRNA 3'-end formation.
GeneRIF
Corbett et al., Atlanta, United States. In J Biol Chem, 2010
Nab2 binding to RNA is critical for proper control of poly(A) tail length.
Signalling to chromatin through post-translational modifications of HMGN.
Review
Mahadevan et al., Oxford, United Kingdom. In Biochim Biophys Acta, 2010
Luger, A.W. Mader, R.K. Richmond, D.F. Sargent, T.J. Richmond, Crystal structure of the nucleosome core particle at 2.8 A resolution, Nature 389 (1997) 251-260 [1] and references therein).
Nuclear transport factor directs localization of protein synthesis during mitosis.
Impact
Poolman et al., Groningen, Netherlands. In Nat Cell Biol, 2009
In yeast, the mRNA-binding proteins Nab2p and Nab4p/Hrp1p accompany transcripts to their translation site, where the karyopherin Kap104p mediates both their dissociation from the mRNA and their transport back into the nucleus.
Signals and genes induced by angiogenic growth factors in comparison to inflammatory cytokines in endothelial cells.
Review
Hofer et al., Vienna, Austria. In Clin Hemorheol Microcirc, 2006
Similarly, NAB2, a corepressor of EGR-1, is induced by EGR-1 and limits EGR-1 effects.
Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins.
Impact
Rout et al., New York City, United States. In Science, 1996
The protein bound directly to repeat-containing nucleoporins and to a cytosolic pool of two nuclear messenger RNA (mRNA) binding proteins, Nab2p and Nab4p.
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